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Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients with Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

Trial Status: Closed to Accrual

This randomized phase II trial studies how well tamoxifen citrate works compared with z-endoxifen hydrochloride in treating patients with breast cancer that has spread to nearby tissue or lymph nodes or other parts of the body and has estrogen receptors but not human epidermal growth factor receptor 2 (HER2) receptors on the surface of its cells. Estrogen can cause the growth of tumor cells. Hormone therapy using tamoxifen citrate or z-endoxifen hydrochloride may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known whether tamoxifen citrate or z-endoxifen hydrochloride is more effective in treating patients with breast cancer.

Inclusion Criteria

  • PRE-REGISTRATION ELIGIBILITY CRITERIA
  • Women who agree to undergo a standard of care core biopsy of recurrent or metastatic breast cancer to confirm the ER+ (>= 10% nuclear staining) and HER2 negative status
  • Patient must have been previously treated with an aromatase inhibitor (either letrozole, anastrozole or exemestane) either in the adjuvant or metastatic setting, and have one of the following types of primary or secondary endocrine resistant disease * Primary clinical resistance is defined as one of the following: ** Recurrence within the first 2 years of adjuvant endocrine therapy while on aromatase inhibitor therapy ** Progression within first 6 months of initiating first-line endocrine therapy (either aromatase inhibitor or fulvestrant containing regimen) for the treatment of metastatic breast cancer * Secondary clinical resistance is defined as one of the following: ** Recurrence after year 2 while receiving adjuvant aromatase inhibitor therapy, or within 12 months of completing adjuvant aromatase inhibitor therapy ** Progression occurring 6 or more months after initiating the first endocrine therapy for metastatic disease (either fulvestrant or aromatase inhibitor containing regimen)
  • Patients with a history of measurable disease as defined by RECIST criteria or bone only disease are eligible; Note: those patients with non-measurable disease and bone metastases are eligible
  • No history of tumors involving spinal cord or heart
  • No current evidence of visceral crisis or lymphangitic spread
  • No known brain metastases
  • Women must be postmenopausal * Postmenopausal status is verified by: ** Prior bilateral surgical oophorectomy, or ** Age >= 60 years, or ** Age < 60 with no menses for > 1 year with follicle-stimulating hormone (FSH) and estradiol levels within post menopausal range, according to institutional standard
  • Prior treatment * No more than two prior chemotherapy regimens in the metastatic setting * Prior treatment with an aromatase inhibitor (either anastrozole, letrozole or exemestane), either in the adjuvant or metastatic setting is required * Unlimited prior endocrine regimens in the metastatic setting, which may have included an everolimus or cyclin dependent kinase (CDK) 4/6 inhibitor (such as palbociclib, abemaciclib or ribociclib) containing regimen * Prior tamoxifen treatment is allowed in the adjuvant setting, but patients must not have experienced relapse within 1 year of stopping tamoxifen * No prior treatment with tamoxifen in the metastatic setting * No prior treatment with endoxifen * Patients who have not fully recovered from acute, reversible effects of prior therapy regardless of interval since last treatment are not eligible to participate in this study ** EXCEPTION: neuropathies-if grade 2 neuropathies have been stable for at least 3 months since completion of prior treatment patient is eligible
  • Not receiving any medications or substances that are strong inhibitors of cytochrome P450 family 2, subfamily D, polypeptide 6 (CYP2D6)
  • Not receiving any other investigational agents
  • No uncontrolled intercurrent illness including, but not limited to: * Ongoing or active infection * Symptomatic congestive heart failure * Unstable angina pectoris * Uncontrolled symptomatic cardiac arrhythmia * Uncontrolled hypertension (defined as blood pressure > 160/90)
  • None of the following co-morbid conditions: * Cataracts of grade 2 or greater as per Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 * Retinopathy of grade 2 or greater as per CTCAE version 4.0 ** Note: patients that have cataracts that do not require surgery are eligible ** Note: serious adverse events will be reported on CTEP-Adverse Event Reporting System (AERS) using CTCAE version (v)5.0 * Deep vein thrombosis/pulmonary embolism (DVT/PE) within the past 6 months ** Note: patients that are on anticoagulant therapy for maintenance are eligible as long as the DVT and/or PE occurred > 6 months prior to enrollment, and there is no evidence for active thrombosis (either DVT or PE)
  • No other active second malignancy other than non-melanoma skin cancers within 3 years of pre-registration; a second malignancy is not considered active if all treatment for that malignancy is completed and the patient has been disease-free for at least 3 years prior to pre-registration
  • Eastern Cooperative Oncology Group (ECOG) performance status: 0-2
  • Able to swallow oral formulation of the study agent
  • Hemoglobin >= 9 g/dL
  • Platelet count >= 75,000/mm^3
  • Creatinine =< 1.5 x upper limits of normal (ULN)
  • Total bilirubin =< 1.5 x upper limits of normal (ULN)
  • Aspartate aminotransferase (AST) =< 2.5 x upper limits of normal (ULN); for patients with liver metastasis: =< 5 x upper limits of normal (ULN)
  • REGISTRATION ELIGIBILITY CRITERIA
  • Patients with either measurable disease as defined by RECIST criteria or bone only disease are eligible; Note: those patients with both non-measurable disease and bone metastases are eligible * Non-measurable bone only disease: Non-measurable bone only disease may include any of the following: blastic bone lesions, lytic bone lesions without a measurable soft-tissue component, or mixed lytic-blastic bone lesions without a measurable soft-tissue component * Lytic bone lesions, with an identifiable soft tissue component, evaluated by computed tomography (CT) or magnetic resonance imaging (MRI), can be considered as measurable lesions if the soft tissue component otherwise meets the definition of measurability previously described
  • No tumors involving spinal cord or heart
  • No visceral crisis, lymphangitic spread or known brain metastases: visceral crisis is not the mere presence of visceral metastases, but implies severe organ dysfunction as assessed by symptoms and signs, laboratory studies, and rapid progression of disease
  • Histologic confirmation, from the A011203 pre-registration biopsy, by institutional/local pathologist of either locally advanced or metastatic breast cancer that is estrogen receptor positive and HER2 negative; those patients with bone only disease with either no tumor or insufficient tumor for ER/progesterone receptor (PR) and HER2 staining after the bone biopsy are still eligible to participate in this study
  • Estrogen receptor positive disease is defined as > 10% nuclear staining
  • HER2 negative disease as per 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines, one of the following must apply: * 0 or 1+ by immunohistochemistry (IHC) and not amplified by in situ hybridization (ISH) * 0 or 1+ by IHC and ISH not done * 2+ by IHC and not amplified by ISH or * IHC not done and not amplified by ISH
  • None of the following therapies are allowed prior to registration: * Chemotherapy =< 2 weeks * Immunotherapy =< 2 weeks * Biologic therapy =< 2 weeks * Hormonal therapy =< 2 weeks * Monoclonal antibodies =< 2 weeks * Radiation therapy =< 2 weeks * Anti-Her-2 or other “targeted” (e.g. mammalian target of rapamycin [mTOR]) therapy =< 2 weeks ** NOTE : Any toxicities derived from these therapies must be =< grade 2 prior to starting study therapy

Alabama

Mobile
Southern Cancer Center PC-Providence
Status: CLOSED_TO_ACCRUAL
Contact: Brian Joseph Heller
Phone: 251-607-5281

Alaska

Anchorage
Alaska Breast Care and Surgery LLC
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Alaska Oncology and Hematology LLC
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Alaska Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Keith S. Lanier
Phone: 503-215-2614
Alaska Women's Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Anchorage Associates in Radiation Medicine
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Anchorage Oncology Centre
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Anchorage Radiation Therapy Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Katmai Oncology Group
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Providence Alaska Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Fairbanks
Fairbanks Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394

Arizona

Phoenix
Mayo Clinic Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Goetz
Phone: 855-776-0015
Scottsdale
Mayo Clinic in Arizona
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Goetz
Phone: 855-776-0015

Arkansas

Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Jonesboro
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Status: CLOSED_TO_ACCRUAL
Contact: Carroll Dean Scroggin
Phone: 870-936-7000

California

Anaheim
Kaiser Permanente-Anaheim
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Arroyo Grande
PCR Oncology
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Auburn
Sutter Auburn Faith Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Bakersfield
AIS Cancer Center at San Joaquin Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Helen K. Chew
Phone: 916-734-3089
Baldwin Park
Kaiser Permanente-Baldwin Park
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Bellflower
Kaiser Permanente-Bellflower
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Burlingame
Mills-Peninsula Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Castro Valley
Eden Hospital Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Davis
Sutter Davis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Dublin
Epic Care-Dublin
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Emeryville
Bay Area Breast Surgeons Inc
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Epic Care Partners in Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Fontana
Kaiser Permanente-Fontana
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Harbor City
Kaiser Permanente - Harbor City
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Irvine
Kaiser Permanente-Irvine
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
La Jolla
UC San Diego Moores Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Barbara A. Parker
Phone: 858-822-5354
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Kaiser Permanente-Cadillac
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Martinez
Contra Costa Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Marysville
Fremont - Rideout Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Helen K. Chew
Phone: 916-734-3089
Merced
Mercy UC Davis Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Parminder S. Sidhu
Phone: 209-564-3600
Modesto
Memorial Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Mountain View
Palo Alto Medical Foundation-Camino Division
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Palo Alto Medical Foundation-Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Novato
Sutter Cancer Research Consortium
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Oakland
Alta Bates Summit Medical Center - Summit Campus
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Bay Area Tumor Institute
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Hematology and Oncology Associates-Oakland
Status: CLOSED_TO_ACCRUAL
Contact: James Henry Feusner
Phone: 510-450-7600
Palo Alto
Palo Alto Medical Foundation Health Care
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Panorama City
Kaiser Permanente - Panorama City
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Riverside
Kaiser Permanente-Riverside
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Sutter Roseville Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Sacramento
Sutter Medical Center Sacramento
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
University of California Davis Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Helen K. Chew
Phone: 916-734-3089
San Diego
Kaiser Permanente-San Diego Mission
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Kaiser Permanente-San Diego Zion
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
San Francisco
California Pacific Medical Center-Pacific Campus
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
San Marcos
Kaiser Permanente-San Marcos
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Santa Rosa
Sutter Pacific Medical Foundation
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Truckee
Gene Upshaw Memorial Tahoe Forest Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Helen K. Chew
Phone: 916-734-3089
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Vallejo
Sutter Solano Medical Center / Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Eunpi Cho
Phone: 415-209-2686
Woodland Hills
Kaiser Permanente-Woodland Hills
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Buchschacher
Phone: 626-564-3455

Colorado

Colorado Springs
Penrose-Saint Francis Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Penrose
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Denver
Porter Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Durango
Mercy Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Southwest Oncology PC
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Golden
Mountain Blue Cancer Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saint Anthony Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Littleton
Littleton Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Longmont
Longmont United Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Longmont
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Parker
Parker Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Parker
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saint Mary Corwin Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Thornton
Rocky Mountain Cancer Centers-Thornton
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Connecticut

Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Middletown
Middlesex Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Susanna Hong
Phone: 860-358-2058

Florida

Daytona Beach
Halifax Health Medical Center-Centers for Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Ruby Anne E. Deveras
Phone: 386-254-4211
Jacksonville
Mayo Clinic in Florida
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Goetz
Phone: 855-776-0015

Georgia

Athens
University Cancer and Blood Center LLC
Status: CLOSED_TO_ACCRUAL
Contact: Sharad Anant Ghamande
Phone: 706-721-1663
Atlanta
Northside Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Amelia Bruce Zelnak
Phone: 404-303-3355
Augusta
Augusta University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Sharad Anant Ghamande
Phone: 706-721-1663
Cumming
Northside Hospital-Forsyth
Status: CLOSED_TO_ACCRUAL
Contact: Amelia Bruce Zelnak
Phone: 404-303-3355
Decatur
Dekalb Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Sharad Anant Ghamande
Phone: 706-721-1663

Hawaii

Aiea
Pali Momi Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Queen's Cancer Center - Pearlridge
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
The Cancer Center of Hawaii-Pali Momi
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Honolulu
Hawaii Cancer Care Inc-Liliha
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Hawaii Cancer Care Inc-POB II
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Island Urology
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Kapiolani Medical Center for Women and Children
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Kuakini Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Queen's Cancer Cenrer - POB I
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Queen's Cancer Center - Kuakini
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Queen's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Straub Clinic and Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
The Cancer Center of Hawaii-Liliha
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
University of Hawaii Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey L. Berenberg
Phone: 808-524-6115

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Luke's Mountain States Tumor Institute
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Coeur D'Alene
Kootenai Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Emmett
Walter Knox Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Fruitland
Saint Luke's Mountain States Tumor Institute - Fruitland
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Meridian
Idaho Urologic Institute-Meridian
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Luke's Mountain States Tumor Institute - Meridian
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Nampa
Saint Alphonsus Medical Center-Nampa
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Luke's Mountain States Tumor Institute - Nampa
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Post Falls
Kootenai Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Sandpoint
Kootenai Cancer Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Twin Falls
Saint Luke's Mountain States Tumor Institute-Twin Falls
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614

Illinois

Aurora
Rush - Copley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Bloomington
Illinois CancerCare-Bloomington
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Saint Joseph Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Canton
Illinois CancerCare-Canton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Carbondale
Memorial Hospital of Carbondale
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Carterville
SIH Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Carthage
Illinois CancerCare-Carthage
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Centralia
Centralia Oncology Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Chicago
John H Stroger Jr Hospital of Cook County
Status: CLOSED_TO_ACCRUAL
Contact: Thomas E. Lad
Phone: 312-864-6000
Northwestern University
Status: CLOSED_TO_ACCRUAL
Contact: Sarika Jain
Phone: 312-695-1301
Presence Saint Joseph Hospital-Chicago
Status: CLOSED_TO_ACCRUAL
Contact: Ira Anton Oliff
University of Chicago Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Olwen Mary Hahn
Phone: 773-834-7424
Danville
Carle on Vermilion
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Decatur Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Effingham
Carle Physician Group-Effingham
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Crossroads Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Elk Grove Village
AMITA Health Alexian Brothers Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kevin Patrick McKian
Phone: 847-952-7164
Eureka
Illinois CancerCare-Eureka
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Galesburg
Illinois CancerCare-Galesburg
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Western Illinois Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Macomb
Illinois CancerCare-Macomb
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Mattoon
Carle Physician Group-Mattoon / Charleston
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Mount Vernon
Good Samaritan Regional Health Center
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
New Lenox
UC Comprehensive Cancer Center at Silver Cross
Status: CLOSED_TO_ACCRUAL
Contact: Olwen Mary Hahn
Phone: 773-834-7424
O'Fallon
Cancer Care Center of O'Fallon
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Radiation Oncology of Northern Illinois
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Pekin
Illinois CancerCare-Pekin
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Peoria
Illinois CancerCare-Peoria
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Methodist Medical Center of Illinois
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
OSF Saint Francis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Peru
Illinois CancerCare-Peru
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Valley Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Princeton
Illinois CancerCare-Princeton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Springfield
Central Illinois Hematology Oncology Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Memorial Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Southern Illinois University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Springfield Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Swansea
Southwest Illinois Health Services LLP
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Urbana
Carle Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
The Carle Foundation Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Yorkville
Rush-Copley Healthcare Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532

Indiana

Indianapolis
Indiana University / Melvin and Bren Simon Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Anna Maria Storniolo
Phone: 317-274-2552
Sidney and Lois Eskenazi Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Anna Maria Storniolo
Phone: 317-274-2552
Springmill Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Anna Maria Storniolo
Phone: 317-274-2552
Michigan City
Franciscan Saint Anthony Health-Michigan City
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Woodland Cancer Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Mishawaka
Memorial Regional Cancer Center Day Road
Status: CLOSED_TO_ACCRUAL
Contact: Thomas Joseph Reid
Phone: 800-284-7370
Richmond
Reid Health
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
South Bend
Memorial Hospital of South Bend
Status: CLOSED_TO_ACCRUAL
Contact: Thomas Joseph Reid
Phone: 800-284-7370

Iowa

Ames
Mary Greeley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
McFarland Clinic PC - Ames
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Boone
McFarland Clinic PC-Boone
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Clive
Medical Oncology and Hematology Associates-West Des Moines
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Mercy Cancer Center-West Lakes
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Council Bluffs
Alegent Health Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Creston
Greater Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Des Moines
Medical Oncology and Hematology Associates-Laurel
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Mercy Medical Center - Des Moines
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Fairfield
JCHC McCreery Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Praveen Vikas
Phone: 641-469-4144
Fort Dodge
McFarland Clinic PC-Trinity Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Jefferson
McFarland Clinic PC-Jefferson
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Marshalltown
McFarland Clinic PC-Marshalltown
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Ottumwa
Ottumwa Regional Health Center
Status: CLOSED_TO_ACCRUAL
Contact: Praveen Vikas
Phone: 641-469-4144
West Des Moines
Mercy Medical Center-West Lakes
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Kansas

Chanute
Cancer Center of Kansas - Chanute
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Dodge City
Cancer Center of Kansas - Dodge City
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
El Dorado
Cancer Center of Kansas - El Dorado
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Fort Scott
Cancer Center of Kansas - Fort Scott
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Independence
Cancer Center of Kansas-Independence
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Kingman
Cancer Center of Kansas-Kingman
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Lawrence
Lawrence Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Liberal
Cancer Center of Kansas-Liberal
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Manhattan
Cancer Center of Kansas-Manhattan
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
McPherson
Cancer Center of Kansas - McPherson
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Newton
Cancer Center of Kansas - Newton
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Parsons
Cancer Center of Kansas - Parsons
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Pratt
Cancer Center of Kansas - Pratt
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Salina
Cancer Center of Kansas - Salina
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Wellington
Cancer Center of Kansas - Wellington
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Wichita
Ascension Via Christi Hospitals Wichita
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Associates In Womens Health
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas - Wichita
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas-Wichita Medical Arts Tower
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Wichita NCI Community Oncology Research Program
Status: ACTIVE
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Winfield
Cancer Center of Kansas - Winfield
Status: CLOSED_TO_ACCRUAL
Contact: Shaker R. Dakhil
Phone: 316-268-5374

Kentucky

Bardstown
Flaget Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Corbin
Baptist Health Corbin
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Commonwealth Cancer Center-Corbin
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Crestview Hills
Oncology Hematology Care Inc-Crestview
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Elizabethtown
Hardin Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Lexington
Baptist Health Lexington
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Saint Joseph Hospital East
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saint Joseph Radiation Oncology Resource Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Louisville
Baptist Health Louisville
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Jewish Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Jewish Hospital Medical Center Northeast
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saints Mary and Elizabeth Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Madisonville
Baptist Health Madisonville / Merle Mahr Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Paducah
Baptist Health Paducah
Status: CLOSED_TO_ACCRUAL
Contact: Ali Hussein Kanbar
Phone: 800-733-2312
Shepherdsville
Jewish Hospital Medical Center South
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Louisiana

Baton Rouge
Ochsner Health Center-Summa
Status: CLOSED_TO_ACCRUAL
Contact: John Thomas Cole
Phone: 888-562-4763
Kenner
Ochsner Medical Center Kenner
Status: CLOSED_TO_ACCRUAL
Contact: John Thomas Cole
Phone: 888-562-4763
New Orleans
Ochsner Medical Center Jefferson
Status: CLOSED_TO_ACCRUAL
Contact: John Thomas Cole
Phone: 888-562-4763

Maine

Augusta
Harold Alfond Center for Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Thomas H. Openshaw
Phone: 800-987-3005
Bangor
Eastern Maine Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Thomas H. Openshaw
Phone: 800-987-3005
Brewer
Lafayette Family Cancer Center-EMMC
Status: CLOSED_TO_ACCRUAL
Contact: Thomas H. Openshaw
Phone: 800-987-3005

Maryland

Elkton
Union Hospital of Cecil County
Status: CLOSED_TO_ACCRUAL
Contact: Fahd Rahman
Phone: 443-406-1374

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Battle Creek
Bronson Battle Creek
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Brighton
IHA Hematology Oncology Consultants-Brighton
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Joseph Mercy Brighton
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Canton
IHA Hematology Oncology Consultants-Canton
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Joseph Mercy Canton
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Caro
Caro Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Chelsea
IHA Hematology Oncology Consultants-Chelsea
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Joseph Mercy Chelsea
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Clarkston
Hematology Oncology Consultants-Clarkston
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Newland Medical Associates-Clarkston
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Dearborn
Beaumont Hospital - Dearborn
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Detroit
Ascension Saint John Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
East China
Great Lakes Cancer Management Specialists-Doctors Park
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Flint
Genesee Cancer and Blood Disease Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Genesee Hematology Oncology PC
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Genesys Hurley Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Hurley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Grand Rapids
Mercy Health Saint Mary's
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Spectrum Health at Butterworth Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Grosse Pointe Woods
Academic Hematology Oncology Specialists
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Michigan Breast Specialists-Grosse Pointe Woods
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Jackson
Allegiance Health
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Kalamazoo
Borgess Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Lansing
Sparrow Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Livonia
Hope Cancer Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Mary Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Michigan Breast Specialists-Macomb Township
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Marlette
Saint Mary's Oncology / Hematology Associates of Marlette
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Midland
Mid-Michigan Medical Center - Midland
Status: CLOSED_TO_ACCRUAL
Contact: Michel Rene Hurtubise
Phone: 989-839-3377
Monroe
Monroe Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Henry Muler
Phone: 419-824-1842
Muskegon
Mercy Health Mercy Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Niles
Lakeland Hospital Niles
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Pontiac
21st Century Oncology-Pontiac
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Hope Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Newland Medical Associates-Pontiac
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Joseph Mercy Oakland
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Port Huron
Lake Huron Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Reed City
Spectrum Health Reed City Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saginaw
Ascension Saint Mary's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Oncology Hematology Associates of Saginaw Valley PC
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint Joseph
Lakeland Medical Center Saint Joseph
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Marie Yeager Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Traverse City
Munson Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Warren
Advanced Breast Care Center PLLC
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Great Lakes Cancer Management Specialists-Macomb Professional Building
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Macomb Hematology Oncology PC
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Michigan Breast Specialists-Warren
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Saint John Macomb-Oakland Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
West Branch
Saint Mary's Oncology / Hematology Associates of West Branch
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Wyoming
Metro Health Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Ypsilanti
Huron Gastroenterology PC
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
IHA Hematology Oncology Consultants-Ann Arbor
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673

Minnesota

Bemidji
Sanford Joe Lueken Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Brainerd
Essentia Health Saint Joseph's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Duluth
Essentia Health Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Essentia Health Saint Mary's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Miller-Dwan Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Rochester
Mayo Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Goetz
Phone: 855-776-0015
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Donald James Jurgens
Phone: 877-229-4907

Mississippi

Jackson
University of Mississippi Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Barbara S. Craft
Phone: 601-815-6700
Pascagoula
Singing River Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James E. Clarkson
Phone: 228-809-5292

Missouri

Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Bolivar
Central Care Cancer Center - Bolivar
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Bonne Terre
Parkland Health Center-Bonne Terre
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Branson
Cox Cancer Center Branson
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Cape Girardeau
Saint Francis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Southeast Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Columbia
University of Missouri - Ellis Fischel
Status: CLOSED_TO_ACCRUAL
Contact: Clint Daniel Kingsley
Phone: 573-882-7440
Creve Coeur
Siteman Cancer Center at West County Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Cynthia Xiuguang Ma
Phone: 800-600-3606
Jefferson City
Capital Region Southwest Campus
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Joplin
Freeman Health System
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital Joplin
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Rolla
Delbert Day Cancer Institute at PCRMC
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Clinic-Rolla-Cancer and Hematology
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Saint Louis
Mercy Hospital Saint Louis
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Missouri Baptist Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Saint Louis Cancer and Breast Institute-South City
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Washington University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: Cynthia Xiuguang Ma
Phone: 800-600-3606
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Cynthia Xiuguang Ma
Phone: 800-600-3606
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Springfield
CoxHealth South Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital Springfield
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Sullivan
Missouri Baptist Sullivan Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740

Montana

Anaconda
Community Hospital of Anaconda
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Billings
Billings Clinic Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Saint Vincent Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Bozeman
Bozeman Deaconess Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Butte
Saint James Community Hospital and Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Great Falls Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Helena
Saint Peter's Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Kalispell
Kalispell Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Missoula
Community Medical Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Saint Patrick Hospital - Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274

Nebraska

Grand Island
CHI Health Saint Francis
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Kearney
CHI Health Good Samaritan
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Heartland Hematology and Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Lincoln
Saint Elizabeth Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Omaha
Alegent Health Bergan Mercy Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Alegent Health Immanuel Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Alegent Health Lakeside Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Creighton University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Hematology and Oncology Consultants PC
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
University of Nebraska Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Elizabeth C. Reed
Phone: 402-559-6941
Papillion
Midlands Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Nevada

Carson City
Carson Tahoe Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Henderson
21st Century Oncology-Henderson
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Henderson
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Henderson
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Henderson
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas
21st Century Oncology
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Fort Apache
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Vegas Tenaya
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Ann M Wierman MD LTD
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer Therapy and Integrative Medicine
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Shadow
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Tenaya
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Central Valley
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Northwest
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Summerlin
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Centennial Hills
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Maryland Parkway
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-San Martin
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Tenaya
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
OptumCare Cancer Care at Fort Apache
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Central
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Southeast
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Summerlin Hospital Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Reno
Renown Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
Saint Mary's Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 773-702-9171

New Hampshire

Lebanon
Dartmouth Hitchcock Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter Andrew Kaufman
Phone: 800-639-6918
Manchester
Norris Cotton Cancer Center-Manchester
Status: CLOSED_TO_ACCRUAL
Contact: Peter Andrew Kaufman
Phone: 800-639-6918
Nashua
Norris Cotton Cancer Center-Nashua
Status: CLOSED_TO_ACCRUAL
Contact: Peter Andrew Kaufman
Phone: 800-639-6918

New Mexico

Albuquerque
University of New Mexico Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Ursa A. Brown-Glaberman
Phone: 505-925-0366

New York

Brooklyn
State University of New York Downstate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Iuliana Shapira
Phone: 718-613-8324
Lake Success
Northwell Health / Center for Advanced Medicine
Status: CLOSED_TO_ACCRUAL
Contact: Ruby Sharma
Phone: 516-734-8954

North Carolina

Asheville
AdventHealth Infusion Center Asheville
Status: CLOSED_TO_ACCRUAL
Contact: Raymond Thertulien
Phone: 855-774-5433
Belmont
Gaston Hematology and Oncology Associates-Belmont
Status: CLOSED_TO_ACCRUAL
Contact: William J. Charles
Phone: 704-865-5210
Cary
Waverly Hematology Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Mark L. Graham
Phone: 919-233-8585
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Katherine E. Reeder-Hayes
Phone: 877-668-0683
Clinton
Sampson Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Southeastern Medical Oncology Center-Clinton
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Durham
Duke University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Crawford
Phone: 888-275-3853
Gastonia
CaroMont Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William J. Charles
Phone: 704-865-5210
Gaston Hematology and Oncology Associates
Status: CLOSED_TO_ACCRUAL
Contact: William J. Charles
Phone: 704-865-5210
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Wayne Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Wayne Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Henderson
Maria Parham Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Crawford
Phone: 888-275-3853
Hendersonville
AdventHealth Hendersonville
Status: CLOSED_TO_ACCRUAL
Contact: Raymond Thertulien
Phone: 855-774-5433
Hendersonville Hematology and Oncology at Pardee
Status: ACTIVE
Contact: James Earl Radford
Phone: 828-696-4716
Margaret R Pardee Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Earl Radford
Phone: 828-696-4716
Jacksonville
Onslow Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Southeastern Medical Oncology Center-Jacksonville
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Kinston
Vidant Oncology-Kinston
Status: CLOSED_TO_ACCRUAL
Contact: Peter Robins Watson
Phone: 252-559-2200
Laurinburg
Scotland Memorial Hospital-Laurinburg Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Crawford
Phone: 888-275-3853
Lumberton
Southeastern Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Crawford
Phone: 888-275-3853
Shelby
Cleveland Hematology and Oncology Associates PC
Status: CLOSED_TO_ACCRUAL
Contact: William J. Charles
Phone: 704-865-5210
Smithfield
Johnston Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Crawford
Phone: 888-275-3853
Winston-Salem
Wake Forest University Health Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Susan A. Melin
Phone: 336-713-6771

North Dakota

Bismarck
Sanford Bismarck Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Fargo
Essentia Health Cancer Center-South University Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Bret E.B. Friday
Phone: 888-203-7267
Sanford Broadway Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Sanford Clinic North-Fargo
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Sanford Roger Maris Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Grand Forks
Altru Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Grant Richard Seeger
Phone: 701-780-6520

Ohio

Akron
Cleveland Clinic Akron General
Status: CLOSED_TO_ACCRUAL
Contact: Esther Hoogland Rehmus
Phone: 330-344-6348
Belpre
Strecker Cancer Center-Belpre
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Canton
Aultman Health Foundation
Status: CLOSED_TO_ACCRUAL
Contact: Shruti Trehan
Phone: 330-363-6891
Mercy Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mitchell Haut
Phone: 888-293-4673
Centerville
Dayton Physicians LLC-Miami Valley South
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital South
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Chillicothe
Adena Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Cincinnati
Bethesda North Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Good Samaritan Hospital - Cincinnati
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Oncology Hematology Care Inc-Anderson
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Blue Ash
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Eden Park
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Kenwood
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Mercy West
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
TriHealth Cancer Institute-Anderson
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
TriHealth Cancer Institute-Westside
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Columbus
Columbus Oncology and Hematology Associates Inc
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Doctors Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Grant Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Mount Carmel East Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Mount Carmel Health Center West
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Ohio State University Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Bhuvaneswari Ramaswamy
Phone: 800-293-5066
Riverside Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
The Mark H Zangmeister Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Dayton
Dayton Physician LLC-Miami Valley Hospital North
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Good Samaritan Hospital - Dayton
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital North
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Delaware
Delaware Health Center-Grady Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Delaware Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Grady Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Fairfield
Oncology Hematology Care Inc-Healthplex
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Findlay
Armes Family Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Blanchard Valley Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Orion Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Franklin
Atrium Medical Center-Middletown Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Dayton Physicians LLC-Atrium
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Greenville
Dayton Physicians LLC-Wayne
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Wayne Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Kettering
First Dayton Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Greater Dayton Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Kettering Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Lancaster
Fairfield Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Mansfield
OhioHealth Mansfield Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Marietta
Marietta Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Marion
OhioHealth Marion General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Middletown
Dayton Physicians LLC-Signal Point
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Mount Vernon
Knox Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Newark
Licking Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Newark Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Portsmouth
Southern Ohio Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Sidney
Dayton Physicians LLC-Wilson
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Springfield
Springfield Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Springfield Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Sylvania
ProMedica Flower Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Henry Muler
Phone: 419-824-1842
Toledo
ProMedica Toledo Hospital / Russell J Ebeid Children's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey Henry Muler
Phone: 419-824-1842
Troy
Dayton Physicians LLC-Upper Valley
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Upper Valley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Westerville
Saint Ann's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Zanesville
Genesis Healthcare System Cancer Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745

Oklahoma

Lawton
Cancer Centers of Southwest Oklahoma Research
Status: CLOSED_TO_ACCRUAL
Contact: Wajeeha Razaq
Phone: 405-271-8777
Oklahoma City
University of Oklahoma Health Sciences Center
Status: CLOSED_TO_ACCRUAL
Contact: Wajeeha Razaq
Phone: 405-271-8777

Oregon

Baker City
Saint Alphonsus Medical Center-Baker City
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Bend
Saint Charles Health System
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Clackamas
Clackamas Radiation Oncology Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Providence Cancer Institute Clackamas Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Coos Bay
Bay Area Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Newberg
Providence Newberg Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Ontario
Saint Alphonsus Medical Center-Ontario
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Oregon City
Providence Willamette Falls Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Portland
Providence Portland Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Providence Saint Vincent Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614

Pennsylvania

Abington
Abington Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Willard G. Andrews
Phone: 215-481-2402
Allentown
Lehigh Valley Hospital-Cedar Crest
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Status: CLOSED_TO_ACCRUAL
Contact: Tareq Al Baghdadi
Phone: 734-712-4673
Danville
Geisinger Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Doylestown
Doylestown Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mitchell B. Alden
Phone: 215-345-2378
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Lewisburg
Geisinger Medical Oncology-Lewisburg
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Lewistown
Lewistown Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Pottsville
Geisinger Cancer Services-Pottsville
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Scranton
Community Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
State College
Geisinger Medical Group
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251
Wilkes-Barre
Geisinger Wyoming Valley / Henry Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Victor G. Vogel
Phone: 570-271-5251

South Carolina

Charleston
Bon Secours Saint Francis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Charleston Oncology - Roper
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Charleston Oncology - Saint Francis
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Lowcountry Hematology Oncology PA-North Charleston
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Lowcountry Hematology Oncology PA-West Ashley
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Roper Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386
Greenville
Saint Francis Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert D. Siegel
Phone: 864-255-1713
Saint Francis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Robert D. Siegel
Phone: 864-255-1713
Greenwood
Self Regional Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Carolyn Dolores Britten
Phone: 843-792-9321
Mount Pleasant
Lowcountry Hematology Oncology PA-Mount Pleasant
Status: CLOSED_TO_ACCRUAL
Contact: Steven Alan Akman
Phone: 843-720-8386

South Dakota

Sioux Falls
Sanford Cancer Center Oncology Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161
Sanford USD Medical Center - Sioux Falls
Status: CLOSED_TO_ACCRUAL
Contact: Preston D. Steen
Phone: 701-234-6161

Tennessee

Chattanooga
Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Ooltewah
Memorial GYN Plus
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Texas

Bryan
Saint Joseph Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Virginia

Mechanicsville
Bon Secours Memorial Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William Johnson Irvin
Phone: 804-594-4900
Midlothian
Bon Secours Saint Francis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William Johnson Irvin
Phone: 804-594-4900
Richmond
Bon Secours Saint Mary's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: William Johnson Irvin
Phone: 804-594-4900

Washington

Aberdeen
Providence Regional Cancer System-Aberdeen
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Anacortes
Cancer Care Center at Island Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Auburn
MultiCare Auburn Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Bainbridge Island
Virginia Mason Bainbridge Island Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Bellevue
Overlake Hospital Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Swedish Cancer Institute-Eastside Oncology Hematology
Status: CLOSED_TO_ACCRUAL
Contact: Keith S. Lanier
Phone: 503-215-2614
Bellingham
PeaceHealth Saint Joseph Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Harrison Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Burien
Highline Medical Center-Main Campus
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Centralia
Providence Regional Cancer System-Centralia
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Edmonds
Swedish Cancer Institute-Edmonds
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Enumclaw
Saint Elizabeth Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Everett
Providence Regional Cancer Partnership
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Federal Way
Saint Francis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Virginia Mason Federal Way Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Gig Harbor
MultiCare Gig Harbor Medical Park
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Tacoma / Valley Radiation Oncology Centers-Gig Harbor
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Issaquah
Swedish Cancer Institute-Issaquah
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Lacey
Providence Regional Cancer System-Lacey
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Lakewood
Saint Clare Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Longview
PeaceHealth Saint John Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Lynnwood
Virginia Mason Lynnwood Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Port Townsend
Jefferson Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Peninsula Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Puyallup
MultiCare Good Samaritan Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Tacoma / Valley Radiation Oncology Centers-Puyallup
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Seattle
Kaiser Permanente Washington
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Minor and James Medical PLLC
Status: CLOSED_TO_ACCRUAL
Contact: Keith S. Lanier
Phone: 503-215-2614
Pacific Gynecology Specialists
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Swedish Medical Center-Ballard Campus
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Swedish Medical Center-First Hill
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Virginia Mason Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Shelton
Providence Regional Cancer System-Shelton
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Spokane
Evergreen Hematology and Oncology PS
Status: CLOSED_TO_ACCRUAL
Contact: Keith S. Lanier
Phone: 503-215-2614
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
MultiCare Deaconess Cancer and Blood Specialty Center - North
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
MultiCare Tacoma General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Northwest Medical Specialties PLLC
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Northwest NCI Community Oncology Research Program
Status: ACTIVE
Contact: John A. Keech
Phone: 253-403-2394
Tacoma / Valley Radiation Oncology Centers-Jackson Hall
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Tacoma / Valley Radiation Oncology Centers-Saint Joe's
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Vancouver
PeaceHealth Southwest Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Walla Walla
Providence Saint Mary Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Keith S. Lanier
Phone: 503-215-2614
Yelm
Providence Regional Cancer System-Yelm
Status: CLOSED_TO_ACCRUAL
Contact: Alison Katherine Conlin
Phone: 503-215-2614

Wisconsin

Mequon
Ascension Columbia Saint Mary's Hospital Ozaukee
Status: CLOSED_TO_ACCRUAL
Contact: Ranveer Nand
Phone: 414-326-2675
Milwaukee
Ascension Columbia Saint Mary's Hospital - Milwaukee
Status: CLOSED_TO_ACCRUAL
Contact: Ranveer Nand
Phone: 414-326-2675
Medical College of Wisconsin
Status: CLOSED_TO_ACCRUAL
Contact: Yee Chung Cheng
Phone: 414-805-4380
Wisconsin Rapids
Aspirus UW Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Ronnie James Kirschling
Phone: 877-405-6866

Wyoming

Cody
Big Horn Basin Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Billings Clinic-Cody
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Sheridan
Welch Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274

PRIMARY OBJECTIVES:

I. To assess whether progression-free survival with z-endoxifen hydrochloride (HCl) relative to that with tamoxifen (tamoxifen citrate) is prolonged in postmenopausal women with local advanced or metastatic estrogen receptor (ER) positive/Her2 negative breast cancer.

SECONDARY OBJECTIVES:

I. To assess the safety profile of each of these agents in this patient population.

II. To assess whether the tumor response rate (as determined using the Response Evaluation Criteria in Solid Tumors [RECIST] criteria) among those randomized to z-endoxifen HCl differs from that among those randomized to tamoxifen.

III. To estimate the median progression-free survival time for those who receive z-endoxifen HCl after disease progression with tamoxifen.

TERTIARY OBJECTIVES:

I. To examine whether ER alpha alterations (defined as either ER activating mutations or ER amplification) are associated with longer progression-free survival (PFS) or higher response rates in the z-endoxifen HCl arm compared to the tamoxifen arm.

II. To determine changes in lipid profiles comparing tamoxifen and z-endoxifen HCl.

III. For each treatment, to evaluate changes in markers of bone formation and absorption after 12 weeks (4 cycles) of treatment.

IV. For all patients and by treatment arm, to determine whether progression-free survival differs with respect to the sensitive to endocrine therapy (SET) index.

V. To examine whether deoxyribonucleic acid (DNA) alterations as measured by Foundation medicine in all coding exons of 287 cancer-related genes as well as 78 polymorphisms in 34 absorption, distribution, metabolism, and excretion (ADME)-related genes are associated with longer PFS or higher response rates in the z-endoxifen HCl arm compared to the tamoxifen arm.

VI. To assess whether the molecular characteristics identified in the tumor biopsies are detectable in the circulating tumor cells (CTCs) and/or cell-free DNA (cfDNA).

VII. For each treatment arm: to examine changes in ER expression on CTCs, changes in estrogen receptor (ESR) mutations or amplification in CTCs or CfDNA and explore the impact of these changes on PFS and response rates.

VIII. To further characterize pharmacokinetics, pharmacogenetics and metabolism of z-endoxifen HCl and tamoxifen.

IX. To determine the impact of the concentrations of tamoxifen and its metabolites on PFS in the tamoxifen arm.

X. To determine the impact of the concentrations of z-endoxifen HCl and its metabolites on PFS in the endoxifen arm.

XI. To determine the impact of genetic variation in the enzymes responsible for tamoxifen and z-endoxifen HCl metabolism.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive z-endoxifen hydrochloride orally (PO) on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive tamoxifen citrate PO once daily (QD) on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients with disease progression and bone metastases may cross over to Arm I and receive z-endoxifen hydrochloride starting no later than 28 days after documentation of disease progression.

After completion of study treatment, patients are followed up yearly for up to 5 years.

Trial Phase Phase II

Trial Type Treatment

Lead Organization
Alliance for Clinical Trials in Oncology

Principal Investigator
Matthew P. Goetz

  • Primary ID A011203
  • Secondary IDs NCI-2014-02409
  • Clinicaltrials.gov ID NCT02311933