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Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And / Or Who Have No Satisfactory Treatment Options

Trial Status: Active

This is an open-label, Phase 1 / 2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain tumors harboring NTRK1 / 2 / 3 or ROS1 gene fusions, and extracranial solid tumors harboring NTRK1 / 2 / 3 or ROS1 gene fusions.

Inclusion Criteria

  • Disease status:
  • Phase 1 portion (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1
  • Phase 2 portion:
  • Part B: Participants must have measurable or evaluable disease, as defined by RANO
  • Part C (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1 ± Curie Scale
  • Part D: Participants must have measurable or evaluable disease, as defined by RECIST v1.1
  • Part E (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1 ± Curie Scale or RANO
  • Tumor type:
  • Phase 1 portion: * Part A: Relapsed or refractory extracranial solid tumors
  • Phase 2 portion
  • Part B: Primary brain tumors with NTRK1/2/3 or ROS1 gene fusions; gene fusions are defined as those predicted to translate into a fusion protein with a functional TRKA/B/C or ROS1 kinase domain, without a concomitant second oncodriver as determined by a nucleic acid-based diagnostic testing method
  • Part D: Extracranial solid tumors (including NB) with NTRK1/2/3 or ROS1 gene fusions; gene fusions are defined as those predicted to translate into a fusion protein with a functional TRKA/B/C or ROS1 kinase domain, without a concomitant second oncodriver as determined by a nucleic acid-based diagnostic testing method
  • Histologic/molecular diagnosis of malignancy at diagnosis or the time of relapse
  • Archival tumor tissue from diagnosis or, preferably, at relapse
  • Performance status: Lansky or Karnofsky score ≥ 60% and minimum life expectancy of at least 4 weeks
  • Prior therapy: Participants must have a disease that is locally advanced, metastatic, or where surgical resection is likely to result in severe morbidity, and who have no satisfactory treatment options for solid tumors and primary CNS tumors that are neurotrophic tyrosine receptor kinase (NTRK) or ROS1 fusion-positive
  • Participants must have recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to enrollment
  • Adequate organ and neurologic function
  • Females of childbearing potential must have a negative serum pregnancy test during screening and be neither breastfeeding nor intending to become pregnant during study participation. Agreement to remain abstinent or use use combined contraceptive methods prior to study entry, for the duration of study participation and in the following 90 days after discontinuation of study treatment.
  • For male participants with a female partner of childbearing potential or a pregnant female partner: Agreement to remain abstinent or use a condom during the treatment period and for at least 3 months after the last dose of study drug

Exclusion Criteria

  • Receiving other experimental therapy
  • Known congenital long QT syndrome
  • History of recent (3 months) symptomatic congestive heart failure or ejection fraction ≤50% at screening
  • Known active infections
  • Familial or personal history of congenital bone disorders, bone metabolism alterations or osteopenia
  • Receiving Enzyme Inducing Antiepileptic Drugs (EIAEDs) within 14 days of first dose.
  • Prior treatment with approved or investigational TRK or ROS1 inhibitors
  • Known hypersensitivity to entrectinib or any of the other excipients of the investigational medicinal product
  • Patients with NB with bone marrow space-only disease
  • Incomplete recovery from acute effects of any surgery prior to treatment.
  • Active gastrointestinal disease or other malabsorption syndromes that would impact drug absorption.
  • Other severe acute or chronic medical or psychiatric condition or lab abnormality that may increase the risk associated with study participation, drug administration or may interfere with the interpretation of study results.

California

San Diego
Rady Children's Hospital - San Diego
Status: ACTIVE
San Francisco
UCSF Medical Center-Mount Zion
Status: ACTIVE

Colorado

Aurora
Children's Hospital Colorado
Status: ACTIVE

Georgia

Atlanta
Children's Healthcare of Atlanta - Egleston
Status: ACTIVE
Contact: William Thomas Cash

Illinois

Chicago
University of Chicago Comprehensive Cancer Center
Status: ACTIVE

Maryland

Baltimore
Johns Hopkins University / Sidney Kimmel Cancer Center
Status: ACTIVE

Massachusetts

Boston
Boston Children's Hospital
Status: ACTIVE
Dana-Farber Cancer Institute
Status: ACTIVE
Contact: Suzanne Shusterman
Phone: 877-442-3324

Minnesota

Minneapolis
University of Minnesota / Masonic Cancer Center
Status: ACTIVE

Missouri

Saint Louis
Siteman Cancer Center at Washington University
Status: ACTIVE

New York

New York
Memorial Sloan Kettering Cancer Center
Status: ACTIVE
NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center
Status: ADMINISTRATIVELY_COMPLETE

Ohio

Columbus
Nationwide Children's Hospital
Status: ACTIVE

Oregon

Portland
OHSU Knight Cancer Institute
Status: ACTIVE

Pennsylvania

Philadelphia
Children's Hospital of Philadelphia
Status: ACTIVE

Tennessee

Memphis
Saint Jude Children's Research Hospital
Status: ACTIVE

Texas

Houston
Texas Children's Hospital
Status: ACTIVE

Utah

Salt Lake City
Primary Children's Hospital
Status: ACTIVE

Trial Phase Phase I/II

Trial Type Treatment

Lead Organization
Hoffmann-La Roche

  • Primary ID RXDX-101-03
  • Secondary IDs NCI-2016-00924, CO40778
  • Clinicaltrials.gov ID NCT02650401