2022 - Updates & Insights Blog

Charting Out New Mysteries with a Tumor Atlas for Small Cell Lung Cancer: Researcher Interview with Charles Rudin and Dana Pe’er
- By Peggy I. Wang
- June 23, 2022
By uncovering new cell states and how cell states may change, researchers are gaining much needed insights into how small cell lung cancer develops and progresses. Dr. Charles Rudin and Dr. Dana Pe’er from NCI’s Human Tumor Atlas Network (HTAN) discuss how they are using single-cell technologies to learn more about this deadly form of lung cancer.
EcDNAs are Extrachromosomal, Extra Active, and Extra Terrifying: Researcher Interviews with Chia-Lin Wei, Roel Verhaak, and Howard Chang
- By Peggy I. Wang
- April 20, 2022
Extrachromosomal DNA (ecDNA) are emerging as oncogenic elements in cancer genomes. Dr. Chia-Lin Wei, Dr. Roel Verhaak, and Dr. Howard Chang are studying the interactions ecDNAs have with chromatin and amongst each other, revealing novel mechanisms of activating oncogenes and suggesting a bigger role for ecDNAs in cancer than previously appreciated.