2018 - Updates & Insights Blog
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Meticulous Reconstructions of Tumor Origins With Single-Cell DNA Sequencing: Researcher Interview with Nicholas NavinDr. Nicholas Navin talks about single-cell DNA sequencing and his research, considerations for working in the single-cell sequencing space, and what’s next for his lab.
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From Bench to Desk: Transitioning from the Laboratory to Project ManagementMy name is Eva Tonsing-Carter, and I recently became the Scientific Program Manager for the Human Cancer Models Initiative (HCMI) in the Office of Cancer Genomics (OCG) within the National Cancer Institute (NCI).
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OCG’s Data Coordinating Center: Facilitating the Sharing of Data Generated by the Office’s InitiativesToday, cancer research studies by different research groups produce vast amounts of data in widely varying formats.
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Genomic Discoveries in Pediatric Mixed Phenotype Acute Leukemia Inform Therapeutic ApproachesThe principal subtypes of acute leukemia are acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). These are driven by distinct mutational profiles and arise from different developing blood cells.
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OCG’s Efforts in the Discovery and Validation of Tissue Samples for the HIV+ Tumor Molecular Characterization Project (HTMCP)The success of antiretroviral therapy and prevention education has led to a dramatic decrease in new HIV (human immunodeficiency virus) positive cases in the United States (U.S.) since the 1980s.
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CytoScreen: A Miniaturized Imaging Platform to Develop Combinatorial TherapiesHematologic malignancies represent the fifth most common type of cancer and fourth most common form of cancer-related death. More than 1 million people in the U.S.
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ATAC-seq on TCGA: Insights Into the Noncoding Region in Primary CancersResearchers used ATAC-seq to profile the chromatin accessibility of 410 TCGA samples representing 23 primary cancers. The study uncovered a vast number of novel DNA regulatory elements and their potential roles in cancer development, prognosis, and response to therapy.
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Getting to Know the Complexities of Cancer: A 2018 TCGA Symposium PreviewAt the 2018 Cell Symposium, TCGA Legacy: Multi-Omic Studies in Cancer, cancer genomics experts will discuss the latest research in molecularly characterizing cancer, classifying the disease, and the development of targeted therapy. A preview of how some researchers are starting to understand the complex and dynamic aspects of cancer.
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Finding Pediatric Cancer Genomic Data through PGDIThe Pediatric Genomic Data Inventory (PGDI), developed by the Office of Cancer Genomics (OCG), is a new public resource informing researchers how and where to access globally generated pediatric cancer genomic datasets. Connecting researchers with data and fostering collaborations is key to furthering our understanding of childhood cancers.
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Collecting and Harmonizing Clinical Data Across an International InitiativeThe Human Cancer Models Initiative (HCMI) is an international consortium with the goal to produce and distribute up to 1,000 novel human cancer models.