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NIH FIRST: Strengthening Inclusive Excellence in Biomedical Research

, by Dr. Norman E. Sharpless and Dr. Eliseo Pérez-Stable

Norman E. Sharpless, M.D., and Eliseo J. Pérez-Stable, M.D.

Together, NCI Director Dr. Sharpless and National Institute on Minority Health and Health Disparities Director Dr. Pérez-Stable provide an overview of the NIH FIRST program and promote the current funding opportunity announcement. The FIRST program supports institutions in recruiting diverse cohorts of new faculty and implementing an inclusive culture in which faculty can thrive. Applications for the final FIRST Cohort funding opportunity are due by July 12, 2022.

Year after year, the number of students from historically underrepresented groups that participate in biomedical research training has slowly increased. Yet today, individuals from underrepresented groups remain much less likely to be hired as independently funded faculty researchers. This gap is untenable if science is to thrive in the future. NIH is committed to supporting institutions and programs to change this trajectory.

In September 2021, NIH announced the initial set of awards in the Faculty Institutional Recruitment for Sustainable Transformation (FIRST) program. FIRST funds and supports institutions to recruit diverse cohorts of new faculty and implement and sustain cultures of inclusive excellence where these faculty can thrive, excel, and become independently funded investigators. NIH expects to announce a second set of FIRST awards this summer. 

FIRST has a target budget of $241 million over 9 years, subject to the availability of funds. The NIH Common Fund leads in managing this NIH-wide program, but there is also robust engagement by others across NIH. The Scientific Workforce Diversity Office, National Cancer Institute (NCI), National Institute on Minority Health and Health Disparities (NIMHD), National Heart, Lung, and Blood Institute, and National Institute of Neurological Disorders and Stroke all collaborate in managing FIRST. 

Our institutes, NCI and NIMHD, are proud to administer the program. NCI is managing the FIRST Faculty Cohort awards and NIMHD is managing the FIRST Coordination and Evaluation Center.

We spoke to the inaugural class of awardees during a kickoff meeting in October 2021. This was a rewarding moment that reinforced what we consistently have seen, heard, and felt from the start—a deep commitment to this program from all involved. Issuing these awards was momentous, not only for the institutions that received the highly competitive awards, but also for many at NIH who have worked tirelessly to design and develop the program over the past few years. 

Researchers representing the institutions that received the six cohort awards and the Coordination and Evaluation Center award attended the kickoff meeting. Initially, we planned to issue only four cohort awards. But in response to the many compelling applications we received, the NIH Common Fund and a dozen NIH institutes and centers agreed to contribute additional funds, which allowed us to expand the FIRST set of cohort awards. This was no small feat, and it signals the tremendous commitment to this program across NIH.

FIRST Faculty Cohort Awards, RFA-RM-20-022

PI Name Institution Name Title

August, Avery 

Kotlikoff, Michael I

Cornell University 

Cornell First

Benn, Emma Katherine Tara 

Campbell, Kirk N

Nestler, Eric J

Richardson, Lynne D

Icahn School Of Medicine At Mount Sinai

NIH FIRST Cohort Cluster Hiring Initiative at Icahn School of Medicine at Mount Sinai

Diez-Roux, Ana V

Gitlin, Laura N

Drexel University 

Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research

Vickers, Selwyn M 

Durant, Raegan Winston

Fouad, Mona N

Yates, Clayton

University Of Alabama At Birmingham 

UAB/Tuskegee Faculty Institutional Recruitment for Sustainable Transformation (UAB/TU FIRST) Partnership (NIH U54)

Wong, Frank Y 

Naar, Sylvie

Keel, Pamela

Florida State University

Fostering Institutional Resources for Science Transformation: The FLORIDA-FIRST Health-Science Brigade

Zúñiga De Nuncio, María Luisa 

Reed, Mark Brian

San Diego State University 

SDSU FUERTE: Faculty United Towards Excellence in Research and Transformation Engagement


FIRST Coordination and Evaluation Center Award, RFA-RM-21-019

PI Name Institution Name Title

Ofili, Elizabeth O 

Rivers, Brian M

Morehouse School Of Medicine 

FIRST Coordination and Evaluation Center to promote inclusive excellence


At NIMHD and NCI, we fully support the purpose, goals, and objectives of the FIRST program. These align with

  • NIMHD’s mission and the NIMHD director’s vision to advance the science of minority health and health disparities, which includes strengthening the diversity of the research workforce and building capacity in minority serving institutions
  • NCI programs, such as its flagship diversity training program—the Continuing Umbrella of Research Experiences (CURE)—and new efforts through the NCI Equity and Inclusion Program
  • the NIH UNITE Initiative, which seeks to establish an equitable and civil culture within the biomedical research enterprise and reduce barriers to racial equity in the biomedical research workforce

We are genuinely pleased with the extramural community’s fervor for FIRST, which has continued to build since the program’s launch in December 2020. Strong interest in FIRST yielded a highly competitive set of applications. It was impressive to see such an array of biomedical research areas represented in the applications and in the programs that received cohort awards. 

The institutions receiving awards plan to hire faculty in areas from cardiovascular disease to environmental studies, infection biology to cancer, mental health to health disparities, and more. This breadth demonstrates the determination of extramural biomedical research institutions to build a workforce that genuinely reflects our nation and that cultivates inclusiveness so faculty can excel. 

The FIRST program recently issued its third and final cohort funding announcement, RFA-RM-22-008, with applications due July 12, 2022. We strongly encourage the research community to apply and to sustain the enthusiasm you have shown for FIRST.

This is vitally important work. It is critical that we diversify the biomedical workforce and strengthen inclusiveness at our institutions. 

Our experience launching FIRST gives us a deep optimism for the transformation this program will foster at institutions receiving awards and throughout the extramural research community. Our continued commitment, and the commitment of so many others at NIH to FIRST, is full and unequivocal. 

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