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Childhood Soft Tissue Sarcoma Treatment (PDQ®)

  • Last Modified: 11/06/2014

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Treatment Options for Childhood Soft Tissue Sarcoma

Newly Diagnosed Childhood Soft Tissue Sarcoma
        Fat Tissue Tumors
        Bone and Cartilage Tumors
        Fibrous (Connective) Tissue Tumors
        Skeletal Muscle Tumors
        Smooth Muscle Tumors
        So-called Fibrohistiocytic Tumors
        Peripheral Nervous System Tumors
        Tumors of Unknown Origin (the place where the tumor first formed is not known)
        Blood Vessel Tumors
        Metastatic Childhood Soft Tissue Sarcoma
Recurrent and Progressive Childhood Soft Tissue Sarcoma



Newly Diagnosed Childhood Soft Tissue Sarcoma

Fat Tissue Tumors

Liposarcoma

Treatment of liposarcoma may include the following:

  • Surgery to completely remove the tumor. If the cancer is not completely removed, a second surgery may be done.
  • Chemotherapy to shrink the tumor, followed by surgery.
Bone and Cartilage Tumors

Extraskeletal chondrosarcoma

Treatment of extraskeletal chondrosarcoma may include the following:

Extraskeletal osteosarcoma

Treatment of extraskeletal osteosarcoma may include the following:

In children, it is not clear if chemotherapy improves the tumor's response to treatment.

Fibrous (Connective) Tissue Tumors

Desmoid tumor

Treatment of desmoid tumor may include the following:

If surgery to completely remove the tumor is not possible, treatment to shrink the tumor before surgery may include the following:

Fibrosarcoma

Infantile fibrosarcoma

Treatment of infantile fibrosarcoma (also called congenital fibrosarcoma) may include the following:

Adult-type fibrosarcoma

Treatment of adult-type fibrosarcoma may include the following:

Dermatofibrosarcoma protuberans

Treatment of dermatofibrosarcoma protuberans may include the following:

Inflammatory myofibroblastic tumor

Treatment of inflammatory myofibroblastic tumor may include the following:

  • Surgery to completely remove the tumor when possible.
Low-grade fibromyxoid sarcoma

There is no standard treatment for low-grade fibromyxoid sarcoma.

Myxofibrosarcoma, low-grade

Treatment of myxofibrosarcoma, low-grade may include the following:

Sclerosing epithelioid fibrosarcoma

Treatment of sclerosing epithelioid fibrosarcoma may include the following:

Skeletal Muscle Tumors

Rhabdomyosarcoma

See the PDQ summary on Childhood Rhabdomyosarcoma Treatment.

Smooth Muscle Tumors

Leiomyosarcoma

There is no standard treatment for leiomyosarcoma.

So-called Fibrohistiocytic Tumors

Plexiform fibrohistiocytic tumor

Treatment of plexiform fibrohistiocytic tumor may include the following:

Undifferentiated pleomorphic sarcoma

There is no standard treatment for undifferentiated pleomorphic sarcoma.

Peripheral Nervous System Tumors

Malignant peripheral nerve sheath tumor

The treatment of malignant peripheral nerve sheath tumor may include the following:

It is not clear whether giving radiation therapy or chemotherapy after surgery improves the tumor's response to treatment.

Tumors of Unknown Origin (the place where the tumor first formed is not known)

Alveolar soft part sarcoma

Treatment of alveolar soft part sarcoma may include the following:

Clear cell sarcoma of soft tissue

Treatment of clear cell sarcoma of soft tissue may include the following:

Desmoplastic small round cell tumor

There is no standard treatment for desmoplastic small round cell tumor. Treatment may include the following:

Epithelioid sarcoma

Treatment of epithelioid sarcoma may include the following:

Perivascular epithelioid cell tumors (PEComas)

Treatment of perivascular epithelioid cell tumors may include the following:

Extrarenal (extracranial) rhabdoid tumor

Treatment of extrarenal (extracranial) rhabdoid tumor may include the following:

Extraskeletal myxoid chondrosarcoma

Treatment of extraskeletal myxoid chondrosarcoma may include the following:

Primitive neuroectodermal tumor (PNET)/extraskeletal Ewing tumor

See the PDQ summary on Ewing Sarcoma Treatment.

Synovial sarcoma

Treatment of synovial sarcoma may include the following:

Blood Vessel Tumors

Angiosarcoma (deep)

Treatment of angiosarcoma may include the following:

Epithelioid hemangioendothelioma

Treatment of epithelioid hemangioendothelioma in the liver in infants aged younger than 1 year may include the following:

Treatment of children with epithelioid hemangioendothelioma that has spread may include:

Hemangiopericytoma (infantile)

Treatment of hemangiopericytoma (infantile) may include the following:

Metastatic Childhood Soft Tissue Sarcoma

Treatment of newly diagnosed metastatic childhood soft tissue sarcoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with nonmetastatic childhood soft tissue sarcoma and metastatic childhood soft tissue sarcoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Recurrent and Progressive Childhood Soft Tissue Sarcoma

Treatment of recurrent or progressive childhood soft tissue sarcoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood soft tissue sarcoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.