Clinical Trials to Treat Childhood Astrocytoma
Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG
The purpose of this study is to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive low grade glioma or relapsed or refractory high grade glioma.
Location: 8 locations
INFUSE Bone Graft in Treating Patients with Tibial Pseudarthrosis and Neurofibromatosis 1 Undergoing Surgery
This randomized phase II trial studies how well INFUSE bone graft works in treating patients with tibial pseudarthrosis and neurofibromatosis 1 undergoing surgery. INFUSE bone graft containing recombinant human bone morphogenetic protein-2 and absorbable collagen sponge may increase the rate of healing of the tibia bone.
Location: 10 locations
Peginterferon alfa-2b in Treating Younger Patients with Recurrent or Refractory and Radiographically or Clinically Progressive Pilocytic Astrocytomas and Optic Pathway Gliomas
This phase II trial studies how well peginterferon alfa-2b works in treating younger patients with pilocytic astrocytomas or optic pathway gliomas that have come back or do not respond to treatment and are growing, spreading, or getting worse. Peginterferon alfa-2b may stop tumor growth by preventing cell division and formation of blood vessels in the tumor, and by activating the immune system to attack tumor cells.
Location: Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia