Prevention Clinical Trials for Breast Cancer

This randomized clinical trial studies understanding and predicting breast cancer events after treatment in patients with stage I-III breast cancer. Understanding and predicting events after cancer treatment may help to establish guidelines for reducing exercise intolerance, fatigue, cardiovascular events, and improving overall survival for patients treated for stage I-III breast cancer.
Location: 53 locations

This phase III trial studies how well axillary reverse mapping works in preventing lymphedema in patients with breast cancer undergoing axillary lymph node dissection. Axillary reverse mapping may help to preserve the lymph node drainage system around the breast so as to prevent lymphedema after surgery.
Location: 41 locations

This phase II trial studies how well hydroxychloroquine works in preventing COVID-19 in patients receiving radiation therapy. Hydroxychloroquine has been approved for the prevention and treatment of malaria, a disease caused by a parasite, and the treatment of the autoimmune diseases lupus and rheumatoid arthritis. Hydroxychloroquine has also been shown to have some activity against viruses that are related to SARS-CoV-2, the virus that causes COVID-19, and may help prevent the immune system from becoming overactive when it is fighting the infection. Giving hydroxychloroquine may help prevent infection with SARS-CoV-2 in patients who are receiving radiation therapy for their cancer.
Location: 7 locations

This trial studies the effect of aerobic exercise in changing biomarkers in patients with solid tumors or clonal hematopoiesis, a condition in which some of the patients' blood cells have a different genetic pattern than the rest of the blood cells. Aerobic exercise stimulates and strengthens the heart and lungs, and improves the body’s use of oxygen. This may help prevent or slow the growth of tumors by changing the biomarkers (signs of disease) found in the blood or by preventing recurrence of certain cancers.
Location: 7 locations

Women with dense breast tissue have a higher risk for developing breast cancer. This randomized phase II trial studies whether putting afimoxifene (4-hydroxytamoxifen topical gel) on the breast skin lowers mammographic density compared with putting placebo gel on the breast skin. 4-hydroxytamoxifen topical gel applied to the breast skin may allow the drug to get into the breast and lower risk of breast cancer with fewer unwanted effects than oral tamoxifen.
Location: 7 locations

This trial studies an intelligent tutoring system intervention in enhancing genetic risk assessment in underserved Blacks and Latinas at risk of hereditary breast cancer. The intelligent tutoring system intervention (BRCA-gist) is a web-based tutoring system that provides education about hereditary breast and ovarian cancer. BRCA-gist may enhance the knowledge and use of genetic cancer risk assessments in at-risk Latina and Black women.
Location: 4 locations

This phase II trial studies how well ruxolitinib before surgery works in preventing breast cancer in patients with high risk and precancerous breast conditions. Ruxolitinib may changes the breast cell when administered to participants with precancerous breast conditions. Ruxolitinib may stop the growth of cells by blocking some of the enzymes needed for cell growth.
Location: 6 locations

This randomized phase II trial studies how well crofelemer works in preventing diarrhea in patients with Her2 positive breast cancer who are receiving trastuzumab, pertuzumab, and docetaxel or paclitaxel with or without carboplatin. Crofelemer may prevent the movement of chloride in the gut so as to prevent diarrhea.
Location: 4 locations

This trial phase I studies how well fingolimod works in preventing chemotherapy-induced nerve pain (neuropathy) in patients with breast cancer who are taking paclitaxel. Fingolimod acts by suppressing immune reactions in the brain. This study is being done to see if fingolimod can reduce neuropathy caused by paclitaxel.
Location: 2 locations

This phase 1b trial studies the biologic effect of 9cUAB30 on early stage breast cancer. 9cUAB30 is a retinoid X receptor (RXR)-selective retinoid that acts in a tissue selective manner with the goal of minimizing side effects, a necessary feature of agents under development for cancer prevention.
Location: 4 locations

This trial studies how well a lifestyle intervention works in reducing breast cancer risk through changing body composition and decreasing inflammation in normal weight women. This trial may help researchers learn more about diet and exercise programs designed to decrease body fat in postmenopausal women who are of normal weight but have an elevated risk of breast cancer because of excess body fat.
Location: M D Anderson Cancer Center, Houston, Texas

This trial studies how well weight management and health behavior intervention works in helping patients with hereditary breast and ovarian cancer and Lynch syndrome mutation carriers lose or maintain a healthy weight and lower their risk for cancer. Lifestyle behaviors such as physical activity, diet, and weight management may play a key role in preventing cancers and improving outcomes even in those with hereditary cancer syndromes.
Location: M D Anderson Cancer Center, Houston, Texas

This trial studies the effects of a dietary intervention based on the Alternative Healthy Eating Index (AHEI) on inflammatory markers and breast density in healthy participants. The AHEI is a quantifiable measure of diet quality designed to target food and macronutrient sources that are associated with chronic disease risk. Adherence to the AHEI may be associated with a reduction in inflammatory biomarkers and sex steroid hormone levels compared to other dietary patterns / scores.
Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

This phase II trial studies how well a telephone genetic counseling intervention works in enhancing genetic cancer risk assessment in Latinas at risk of hereditary breast and ovarian cancer. Genetic counseling may help providers and patients make decisions for cancer prevention or cancer treatment. Adapting a telephone genetic counseling intervention in Spanish for Latinas who are at risk of hereditary breast and ovarian cancer may enhance their use of genetic counseling services.
Location: MedStar Georgetown University Hospital, Washington, District of Columbia

This pilot trial studies whether a procedure called lymphovenous bypass would prevent lymphedema (arm swelling) in patients with inflammatory breast cancer or non-inflammatory breast cancer that has spread to nearby tissues or lymph nodes. The lymphovenous bypass procedure creates a path for lymphatic fluid to flow away from the arms. It is usually done after a diagnosis of lymphedema. In this study, giving lymphovenous bypass before underarm lymph node surgery may help prevent lymphedema from forming.
Location: M D Anderson Cancer Center, Houston, Texas

This trial studies how well habit development intervention works in improving healthy dietary and physical activity behaviors and reducing metabolic syndrome and unmet needs in stages I-III breast cancer survivors during the survivorship transition. The habit development intervention may help women develop healthy dietary and physical activity habits and reduce cardiovascular disease risk.
Location: Wayne State University / Karmanos Cancer Institute, Detroit, Michigan

This trial studies how well comprehensive lifestyle change works in preventing patients from breast cancer. A program including dietary recommendations, physical activity, stress management and mindfulness training, learning sleep hygiene techniques, and behavioral counseling in addition to social support may help patients who may be at risk for breast cancer.
Location: M D Anderson Cancer Center, Houston, Texas

This trial studies cancer education and empowerment for preventing and controlling cancer in breast and ovarian cancer survivors and their families. Cancer education strategies, such as targeted generic print and tailored telephone counseling, may help survivors learn more about the risks for hereditary and ovarian breast cancer, as well as learning about current screening guidelines or other cancer prevention measures.
Location: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

This phase II trial studies how well sirolimus works in preventing invasive breast cancer in patients with breast cancer confined to the mammary ducts or lobules of the breast. Sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas

This randomized phase II trial studies omega-3 fatty acids in preventing the return of cancer (recurrence) in patients with hormone receptor-negative or human epidermal growth factor receptor (HER2)-positive stage 0-III breast cancer that have completed treatment. Omega-3 fatty acid may help prevent breast cancer from forming in patients at risk for recurrence.
Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or afimoxifene may fight breast cancer by blocking the use of estrogen by the tumor cells.
Location: 7 locations

This is a pilot study evaluating the effect of hydroxytyrosol, a component of olive oil, on mammographic density in women at high risk of developing breast cancer.
Location: See Clinical Trials.gov

This pilot phase I clinical trial studies how well alendronate sodium works in preventing breast cancer in premenopausal patients that have high risk gene mutations and are undergoing surgery to reduce the risk of breast cancer or are undergoing routine surveillance or are willing to undergo two clinic biopsies. Alendronate sodium may increase the number and activity of special immune cells that are able to kill new tumor cells in breast tissue.
Location: University of Wisconsin Hospital and Clinics, Madison, Wisconsin

This phase III trial studies how well metformin hydrochloride works compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of metformin hydrochloride may prevent breast cancer.
Location: 14 locations

This phase I trial studies the side effects and best dose of bexarotene in preventing breast cancer in patients at high risk for breast cancer.
Location: See Clinical Trials.gov