Prevention Clinical Trials for Breast Cancer

This randomized phase III trial studies how well aspirin works in preventing the cancer from coming back (recurrence) in patients with node positive or high risk node negative, human epidermal growth factor receptor 2 (HER2) negative breast cancer after chemotherapy, surgery, and / or radiation therapy. Aspirin is a drug that reduces pain, fever, inflammation, and blood clotting. It is also being studied in cancer prevention. Giving aspirin may reduce the rate of cancer recurrence in patients with breast cancer.
Location: 1255 locations

This randomized clinical trial studies understanding and predicting breast cancer events after treatment in patients with stage I-III breast cancer. Understanding and predicting events after cancer treatment may help to establish guidelines for reducing exercise intolerance, fatigue, cardiovascular events, and improving overall survival for patients treated for stage I-III breast cancer.
Location: 42 locations

This randomized phase III trial studies metformin hydrochloride to see how well it works compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of metformin hydrochloride may prevent breast cancer.
Location: 23 locations

This trial studies the effect of aerobic exercise in changing biomarkers in patients with solid tumors or clonal hematopoiesis, a condition in which some of the patients' blood cells have a different genetic pattern than the rest of the blood cells. Aerobic exercise stimulates and strengthens the heart and lungs, and improves the body’s use of oxygen. This may help prevent or slow the growth of tumors by changing the biomarkers (signs of disease) found in the blood or by preventing recurrence of certain cancers.
Location: 7 locations

This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or afimoxifene may fight breast cancer by blocking the use of estrogen by the tumor cells.
Location: 6 locations

This randomized phase IIb trial studies how well alternative dosing of exemestane before surgery works in treating in postmenopausal patients with stage 0-II estrogen positive breast cancer. Chemoprevention is the use of drugs to keep breast cancer from forming or coming back. The use of exemestane may treat early stage (stage 0-II) breast cancer. Comparing the exemestane standard dose regimen versus two alternative, less frequent dose regimens may decrease undesirable symptoms and have similar efficacy in reducing serum estradiol.
Location: 3 locations

This trial studies an intelligent tutoring system intervention in enhancing genetic risk assessment in underserved Blacks and Latinas at risk of hereditary breast cancer. The intelligent tutoring system intervention (BRCA-gist) is a web-based tutoring system that provides education about hereditary breast and ovarian cancer. BRCA-gist may enhance the knowledge and use of genetic cancer risk assessments in at-risk Latina and Black women.
Location: 4 locations

This randomized phase II trial studies how well crofelemer works in preventing diarrhea in patients with Her2 positive breast cancer who are receiving trastuzumab, pertuzumab, and docetaxel or paclitaxel with or without carboplatin. Crofelemer may prevent the movement of chloride in the gut so as to prevent diarrhea.
Location: 4 locations

This phase III trial studies how well axillary reverse mapping works in preventing lymphedema in patients with breast cancer undergoing axillary lymph node dissection. Axillary reverse mapping may help to preserve the lymph node drainage system around the breast so as to prevent lymphedema after surgery.
Location: 3 locations

This phase II trial studies community hospital identification with magnetic resonance imaging (MRI) and echocardiography in detecting chemotherapy-related cardiotoxicity in patients with stage I-III breast cancer or lymphoma. Diagnostic procedures, such as MRI and echocardiography, may help find and diagnose chemotherapy-related toxicity in patients. Different ways of measuring heart health will be explored to determine if there are easier and faster ways to measure how chemotherapy may negatively impact the function and size of the heart when being treated for breast cancer or lymphoma at a community hospital.
Location: 3 locations

This phase II trial studies how well ruxolitinib before surgery works in preventing breast cancer in patients with high risk and precancerous breast conditions. Ruxolitinib may changes the breast cell when administered to participants with precancerous breast conditions. Ruxolitinib may stop the growth of cells by blocking some of the enzymes needed for cell growth.
Location: 3 locations

This phase 1b trial studies the biologic effect of 9cUAB30 on early stage breast cancer. 9cUAB30 is a retinoid X receptor (RXR)-selective retinoid that acts in a tissue selective manner with the goal of minimizing side effects, a necessary feature of agents under development for cancer prevention.
Location: 4 locations

This phase I trial studies the side effects and best dose of a vaccine therapy in preventing cancer from coming back in patients with non-metastatic, node positive, human epidermal growth factor receptor (HER)2 negative breast cancer in which all signs and symptoms have disappeared. Vaccines made from deoxyribonucleic acid (DNA) may help the body build an effective immune response to kill tumor cells. Giving multiple vaccinations may make a stronger immune response and prevent or delay the return of cancer.
Location: 2 locations

This pilot trial studies whether a procedure called lymphovenous bypass would prevent lymphedema (arm swelling) in patients with inflammatory breast cancer or non-inflammatory breast cancer that has spread to nearby tissues or lymph nodes. The lymphovenous bypass procedure creates a path for lymphatic fluid to flow away from the arms. It is usually done after a diagnosis of lymphedema. In this study, giving lymphovenous bypass before underarm lymph node surgery may help prevent lymphedema from forming.
Location: M D Anderson Cancer Center, Houston, Texas

This trial phase I studies how well fingolimod works in preventing chemotherapy-induced nerve pain (neuropathy) in patients with breast cancer who are taking paclitaxel. Fingolimod acts by suppressing immune reactions in the brain. This study is being done to see if fingolimod can reduce neuropathy caused by paclitaxel.
Location: Mayo Clinic, Rochester, Minnesota

This trial studies how well habit development intervention works in improving healthy dietary and physical activity behaviors and reducing metabolic syndrome and unmet needs in stages I-III breast cancer survivors during the survivorship transition. The habit development intervention may help women develop healthy dietary and physical activity habits and reduce cardiovascular disease risk.
Location: Wayne State University / Karmanos Cancer Institute, Detroit, Michigan

This phase II / III trial studies how well nitroglycerin ointment, fluorescent angiography, and incisional negative-pressure wound therapy work in preventing skin flap problems in patients undergoing mastectomy. Nitroglycerin ointment may help prevent problems when used after immediate breast reconstruction. Fluorescent angiography uses dye and a specialized camera to inspect blood flow. Negative-pressure wound therapy uses a vacuum dressing to promote healing. These different ways of examining blood flow to the skin remaining after mastectomy are accepted techniques that may improve the outcome of mastectomy and breast reconstruction surgery.
Location: Wake Forest University Health Sciences, Winston-Salem, North Carolina

This trial studies how repetitive transcranial magnetic stimulation works in increasing abstinence and decreasing cigarette consumption in patients with stage I-IIIA cancer. Repetitive transcranial magnetic stimulation uses magnetic pulses to temporarily stimulate specific areas of the brain. Using how repetitive transcranial magnetic stimulation may promote smoking cessation in cancer patients who smoke.
Location: Medical University of South Carolina, Charleston, South Carolina

This phase I trial studies the side effects and best dose of bexarotene in preventing breast cancer in patients at high risk for breast cancer.
Location: M D Anderson Cancer Center, Houston, Texas

This pilot clinical trial studies how well a weight loss intervention works in improving outcomes in patients with breast cancer. Participating in a standard weight loss program consisting of a reduced calorie diet, moderate exercise, and weekly group meetings may help improve the health in patients with breast cancer.
Location: University of Kansas Cancer Center, Kansas City, Kansas

This pilot phase I clinical trial studies how well alendronate sodium works in preventing breast cancer in premenopausal patients that have high risk gene mutations and are undergoing surgery to reduce the risk of breast cancer or are undergoing routine surveillance or are willing to undergo two clinic biopsies. Alendronate sodium may increase the number and activity of special immune cells that are able to kill new tumor cells in breast tissue.
Location: University of Wisconsin Hospital and Clinics, Madison, Wisconsin

This phase II trial studies how well sirolimus works in preventing invasive breast cancer in patients with breast cancer confined to the mammary ducts or lobules of the breast. Sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas

This randomized pilot clinical trial studies how well aerobic exercise training works in lowering the risk of breast cancer in patients at high-risk for development of breast cancer. Aerobic exercise training may help lower the risk of breast cancer patients with risk factors that are associated with developing breast cancer such as exercise capacity, body weight, body composition, the expression of certain genes, and levels of inflammatory factors in breast tissue.
Location: Memorial Sloan Kettering Cancer Center, New York, New York

This randomized phase II trial studies omega-3 fatty acids in preventing the return of cancer (recurrence) in patients with hormone receptor-negative or human epidermal growth factor receptor (HER2)-positive stage 0-III breast cancer that have completed treatment. Omega-3 fatty acid may help prevent breast cancer from forming in patients at risk for recurrence.
Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

This pilot clinical trial studies different types of energy balance interventions to see how well they work in increasing the physical activity levels of breast cancer gene-positive patients, Lynch syndrome-positive patients, chronic lymphocytic leukemia (CLL) survivors or family members of cancer survivors who are at high risk for cancer. Increasing exercise and eating healthy foods may help reduce the risk of cancer. Studying how well different types of interventions work in motivating cancer survivors or high-risk family members to increase exercise and healthy food choices may help doctors plan the most effective motivational program for cancer prevention.
Location: M D Anderson Cancer Center, Houston, Texas