Prevention Clinical Trials for Colon Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer prevention. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Eflornithine and / or Sulindac in Preventing Recurrence of High-Risk Adenomas and Second Primary Disease in Patients with Stage 0-III Colon or Rectal Cancer

    This phase III trial studies how well eflornithine works compared to sulindac in preventing the return of the disease (recurrence) of high-risk adenomas and second primary disease in patients with stage 0-III colon or rectal cancer. Drugs used in chemotherapy, such as eflornithine and sulindac, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 780 locations

  • Fiber to Reduce the Risk of Colon Cancer in Alaska Native People

    This trial studies if increasing the amount of fiber that people eat will change the bacteria that live in the colon and change how those bacteria affect the cells in the colon that can cause colon cancer. Alaska Native people have very high rates of colon cancer. Fiber is a carbohydrate that comes from plants and is not digested by the human body. Fiber that is not broken down, also called cellulose, promotes colon health and normal stool (feces) formation, which helps to prevent diarrhea and constipation. Resistant starches are carbohydrates that behave like fiber in the diet because they are not fully digested like other starches. Resistant starches are fermented by bacteria in the colon, where some healthy nutrients are produced. These resistant starches are thought to promote a healthy and thriving population of beneficial gut bacteria. Comparing volunteers who supplement their usual diet with resistant starch to volunteers who supplement their usual diet with digestible starch may help to see if there are any differences in colon cells between the two groups.
    Location: 2 locations

  • Epigallocatechin Gallate in Treating Patients with Colorectal Cancer That Can Be Removed by Surgery

    This early phase I trial studies how well epigallocatechin gallate works in treating patients with colorectal cancer that can be removed by surgery. Epigallocatechin gallate is a dietary supplement that may help prevent colorectal cancer.
    Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas

  • Fiber-Rich Foods for the Treatment of Obesity and Prevention of Colon Cancer

    This phase II trial investigates whether a high-fiber diet featuring legumes can reduce obesity and colon cancer risk in middle-aged overweight and obese participants that may have undergone removal of a polyp (polypectomy). A natural high-fiber diet based on legumes may lead to greater weight loss and improvements in biomarkers associated with colon cancer risk compared to a control diet.
    Location: Emory University Hospital / Winship Cancer Institute, Atlanta, Georgia