Prevention Clinical Trials for Colon Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer prevention. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-5 of 5
  • Eflornithine and / or Sulindac in Preventing Recurrence of High-Risk Adenomas and Second Primary Disease in Patients with Stage 0-III Colon or Rectal Cancer

    This phase III trial studies how well eflornithine works compared to sulindac in preventing the return of the disease (recurrence) of high-risk adenomas and second primary disease in patients with stage 0-III colon or rectal cancer. Drugs used in chemotherapy, such as eflornithine and sulindac, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 779 locations

  • Fiber to Reduce the Risk of Colon Cancer in Alaska Native People

    This trial studies if increasing the amount of fiber that people eat will change the bacteria that live in the colon and change how those bacteria affect the cells in the colon that can cause colon cancer. Alaska Native people have very high rates of colon cancer. Fiber is a carbohydrate that comes from plants and is not digested by the human body. Fiber that is not broken down, also called cellulose, promotes colon health and normal stool (feces) formation, which helps to prevent diarrhea and constipation. Resistant starches are carbohydrates that behave like fiber in the diet because they are not fully digested like other starches. Resistant starches are fermented by bacteria in the colon, where some healthy nutrients are produced. These resistant starches are thought to promote a healthy and thriving population of beneficial gut bacteria. Comparing volunteers who supplement their usual diet with resistant starch to volunteers who supplement their usual diet with digestible starch may help to see if there are any differences in colon cells between the two groups.
    Location: 2 locations

  • Multi-Level Interventions in Follow-Up in Reducing Rural Colon Cancer Disparities in Participants with Abnormal Screening Tests

    This trial studies how well multi-level interventions in follow-up work in reducing rural colon cancer disparities in participants with abnormal screening tests. Learning about the current processes used to support and monitor colorectal cancer screening, from initiation to results, and through documentation of the recommended screening interval after a diagnostic colonoscopy, may help doctors to develop better screening processes and screening follow-up.
    Location: 2 locations

  • Mesh Reinforcement of Ileostomy Closure for the Prevention of Hernia Formation in Left Sided Colon or Rectal Cancer Patients, SCAR Study

    This trial studies the feasibility of placing a mesh to reinforce the closure of the abdominal wall and prevent hernia formation in left sided colon or rectal cancer patients with an ileostomy. Hernias are a common occurrence and may put unnecessary burden on patients. Reinforcement of an ileostomy closure with mesh may help to prevent the occurrence of hernia formation.
    Location: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

  • Epigallocatechin Gallate in Treating Patients with Colorectal Cancer That Can Be Removed by Surgery

    This early phase I trial studies how well epigallocatechin gallate works in treating patients with colorectal cancer that can be removed by surgery. Epigallocatechin gallate is a dietary supplement that may help prevent colorectal cancer.
    Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas