Prevention Clinical Trials for Colon Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer prevention. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-5 of 5
  • Eflornithine and / or Sulindac in Preventing Recurrence of High-Risk Adenomas and Second Primary Disease in Patients with Stage 0-III Colon or Rectal Cancer

    This randomized phase III trial studies how well eflornithine works compared to sulindac in preventing the return of the disease (recurrence) of high-risk adenomas and second primary disease in patients with stage 0-III colon or rectal cancer. Drugs used in chemotherapy, such as eflornithine and sulindac, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 787 locations

  • Multi-Level Interventions in Follow-Up in Reducing Rural Colon Cancer Disparities in Participants with Abnormal Screening Tests

    This trial studies how well multi-level interventions in follow-up work in reducing rural colon cancer disparities in participants with abnormal screening tests. Learning about the current processes used to support and monitor colorectal cancer screening, from initiation to results, and through documentation of the recommended screening interval after a diagnostic colonoscopy, may help doctors to develop better screening processes and screening follow-up.
    Location: 2 locations

  • Nivolumab in Preventing Colon Adenomas in Participants with Lynch Syndrome and a History of Partial Colectomy

    This phase II trial studies how well nivolumab works in preventing colon adenomas in participants with Lynch syndrome and a history of surgery to remove part of the colon. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread.
    Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

  • Effects of Solar Simulated Light Exposure on Skin Samples from Patients with Metastatic Cancers Treated with Target Therapies

    This pilot clinical trial studies the effects of solar (sun) simulated light exposure on skin sample from patients with melanoma, colon cancer, liver cancer, or thyroid cancer that has spread to other parts of the body (metastatic) treated with target therapies. Therapies known as Raf, mitogen-activated protein kinase kinase (MEK), or protein kinase inhibitors (target therapies) may cause skin side effects such as moles also called melanocytic nevus. Studying the effects of Raf inhibition when given with MEK or protein kinase inhibitors on skin samples before and after solar simulated light exposure may help doctors evaluate changes which occur in the skin of patients undergoing metastatic cancer treatment with Raf.
    Location: The University of Arizona Medical Center-University Campus, Tucson, Arizona

  • Epigallocatechin Gallate in Treating Patients with Colorectal Cancer That Can Be Removed by Surgery

    This randomized pilot early phase I trial studies how well epigallocatechin gallate works in treating patients with colorectal cancer that can be removed by surgery. Epigallocatechin gallate is a dietary supplement that may help prevent colorectal cancer.
    Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas