Screening Clinical Trials for Colorectal Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for colorectal cancer screening. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-13 of 13
  • Screening More Patients for Colorectal Cancer through Adapting and Refining Targeted Evidence-Based Interventions in Rural settings, SMARTER CRC

    This study collects information to provide a model for how to rapidly adapt and scale-up multilevel interventions through clinic-health plan partnerships to reduce the burden of colorectal cancer (CRC) on the United states population. This study may improve colorectal cancer screening rates, follow-up colonoscopy, and referral to care in rural Medicaid patients.
    Location: OHSU Knight Cancer Institute, Portland, Oregon

  • Scaling Colorectal Cancer Screening Through Outreach, Referral, and Engagement (SCORE) Intervention for the Reduction of Colorectal Cancer Burden in Vulnerable Populations

    This clinical trial studies the use of a mailed colorectal cancer screening program called SCORE to improve colorectal cancer (CRC) screening completion in vulnerable populations. The mailed outreach program may increase colorectal cancer screening rates and reduce colorectal cancer burden in vulnerable and marginalized populations.
    Location: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

  • Effect of Mailed Invites of Choice of Colonoscopy or FIT vs. Mailed FIT Alone on Colorectal Cancer Screening

    This is a pragmatic, randomized, controlled trial comparing whether a mailed outreach intervention offering patients who are not up-to-date with colorectal cancer (CRC) a choice of completing a home Fecal Immunochemical Test (FIT) test or scheduling a screening colonoscopy increases CRC screening completion compared to a mailed FIT kit outreach program (which does not offer an explicit choice of screening modality). The trial will be conducted in a racially and socioeconomically diverse cohort of patients served by an integrated safety net delivery system that has a "FIT first" population health screening strategy. All patients will also have access to whatever CRC screening is recommended through usual visit-based care.
    Location: UT Southwestern / Simmons Cancer Center-Dallas, Dallas, Texas

  • Community Health Worker-Led Intervention for the Increase in Uptake of Evidence-Based Screening Services

    This trial studies how well community health worker-led interventions work in increasing the uptake of evidence-based screening services. Comparing home testing led by a community health worker versus clinic testing guided by a community health worker may help researchers find the best way to increase early detection and / or prevention for cervical cancer, colorectal cancer, human immunodeficiency virus, and hepatitis C in Hispanic, Haitian, and African-American people in Hialeah, South Dade, and Little Haiti.
    Location: University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

  • Enhanced Prevention Program in Improving Colorectal Health

    This trial studies how well an enhanced prevention program works in increasing screening in participants at high risk for colorectal cancer. An enhanced prevention program, including self-test kit, educational materials and outreach, and reminders may help participants to understand the benefit of early detection of colorectal cancer, and may help to increase the attendance of annual colorectal cancer screening.
    Location: University of New Mexico Cancer Center, Albuquerque, New Mexico

  • Comparison of Adenoma Detection Rate With ENDOCUFF VISION® vs. G-EYE®

    The study is intended to compare the detection rate obtained by performing G-EYE® high definition colonoscopy vs. the detection rate obtained by performing ECV high definition colonoscopy.
    Location: Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

  • Virtual Human Delivered Nutrition Module for Colorectal Cancer Prevention

    This study uses the opinions of adults between the ages of 50 and 73 years old to develop and test an interactive nutrition module for use in an existing colorectal cancer screening intervention using virtual human technology. This study will contribute to knowledge of what messages and graphics promote understanding of cancer risk and promote screening.
    Location: University of Florida Health Science Center - Gainesville, Gainesville, Florida

  • A Patient-centered Intervention Using Technology to Reduce Colorectal Cancer Disparities in Primary Care

    The purpose of this proposal is to test the efficacy of a patient-centered, tailored message intervention delivered via virtual technology for increasing colorectal cancer (CRC) screening within guidelines among racial / ethnic minority and rural patients. This protocol focuses on the clinical portion of grant NCI 1RCA207689-01A1
    Location: University of Florida Health Science Center - Gainesville, Gainesville, Florida

  • Paired Promotion of Colorectal Cancer and Social Determinants of Health Screening

    This work is an implementation science study that examines different aspects of implementing a single intervention. The intervention consists of asking community health centers to implement an outreach strategy to screen patients for colorectal cancer and for social determinants of health in community health centers at the same contact point. These are both clinical targets that the CHCs feel that their patients need and want to offer at a higher rate. The intervention consists of outreach to patients in need of colorectal cancer screening (CRC) to offer fecal immunochemical test (FIT) screening and screening for social determinants of health (SDOH). In this implementation science study, the intervention is an evidence-based intervention being implemented in real-world clinical practice. The intervention is the outreach to offer FIT and SDOH, conducted by clinic staff. Both evidence-based screening activities-FIT and SDOH screening-are used in the practices included in the study but pairing them is intended to increase efficiency and patient-centeredness by addressing health related social needs that may impact patients' ability to engage in cancer screening. The study aims to test the effect of implementing the intervention on clinical and process outcomes. Clinical outcomes are CRC screening and SDOH screening. Analysis of process outcomes includes measuring what organizational factors influence implementation.
    Location: Dana-Farber Cancer Institute, Boston, Massachusetts

  • Predicting and Addressing Colonoscopy in Safety Net Settings

    The prospective cohort study will evaluate the effectiveness of patient navigation in community health center settings. The investigators will collaborate with the advisory board, composed of key clinicians and patients, researchers, and policymakers, to establish a procedure to conduct and evaluate a patient navigation program that aims to increase rates of follow-up colonoscopy among diverse patient populations served by safety net clinics. Phase 1 will be a milestone-driven planning process in which the investigators will validate the risk prediction model and apply the risk prediction model to stratify the patients and adapt patient navigation materials for the local context. Phase II will be a large-scale, patient randomized-controlled trial that will include 1200 patients at a large 34-clinic community health center in Washington State.
    Location: Kaiser Permanente Northwest Center for Health Research, Portland, Oregon

  • Multilevel Intervention Based on Colorectal Cancer (CRC) and Cervical Cancer Self-screening in Rural, Segregated Areas

    In this study, the investigators will deliver self-sampling human papillomavirus (HPV) tests and fecal immunochemical test (FIT) kits, as well as adapted cancer screening educational materials, by mail to 110 women who are out-of-date for both cervical and colorectal cancer screenings, recruited through federally qualified health centers (FQHCs) in rural, segregated counties of Pennsylvania. The hypothesis is that delivering self-sampling HPV tests and FIT, as well as adapted educational materials, to women in rural, segregated areas could help overcome environment- and person-level barriers and thereby increase cancer screening, reduce geographic cancer disparities, and improve public health.
    Location: Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania

  • Helping Patients and Providers Make Better Decisions about Colorectal Cancer Screening

    This clinical trial compares screening behavior and decision quality of patients eligible for colorectal cancer (CRC) screening who view a decision aid that includes general information about CRC, and colonoscopy and stool tests (i.e. fecal immunochemical test [FIT] and Cologuard) to those who view the same decision aid with a personalized message about their risk of having an advanced colorectal neoplasm (ACN). The study also aims to compare the impact of sending an email notification to enrolled patients’ providers, half of whom will receive a notification that informs them of their patient’s current risk of ACN and implications for screening test choice, and half will receive a notification that just informs them that their patient is due for CRC screening.
    Location: Indiana University / Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

  • Genetic Testing in Screening Patients with Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial

    This trial screens patients with colon or rectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) for genetic mutations for recommendation to a molecularly assigned therapy. Identifying gene mutations may help patients enroll onto target companion trials that target these mutations.
    Location: 18 locations