Screening Clinical Trials for Esophageal Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for esophageal cancer screening. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Non-endoscopic Screening and Surveillance in Patients with Barrett’s Esophagus

    This trial studies the development of non-endoscopic screening and surveillance procedures to assess the relationship between the microbiome (bacteria and other organisms that live inside the body) and tissue inflammation in patients with Barrett’s esophagus who are at risk for developing esophageal adenocarcinoma. A key factor in Barrett's esophagus and esophageal adenocarcinoma is chronic inflammation. Chronic inflammation can lead to an altered microbiome, a “dysbiosis” that can sustain the chronic inflammatory environment and cause broad changes in the tumor microenvironment (normal cells, molecules, and blood vessels that surround and feed a tumor cell). Understanding this tumor microenvironment may help in developing a non-endoscopic testing strategy based on pathogenic factors to identify those patients at highest risk for developing esophageal adenocarcinoma.
    Location: 3 locations