Prevention Clinical Trials for Melanoma

Clinical trials are research studies that involve people. The clinical trials on this list are for melanoma prevention. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Gene-Environment Interactions in Participants with or without Melanoma or Nevi

    The purpose of this trial is to measure the amount of ultraviolet (UV) radiation a person may receive. Invisible rays that are part of the energy that comes from the sun are called UV radiation. It is known that a form of skin cancer called melanoma is related to skin damage caused by UV exposure, but it is not fully understood which types of UV cause which types of skin damage. This trial also studies the gene-environment interactions in participants with or without melanoma or nevi. Measuring the amount of an individual’s ultraviolet (UV) exposure may help doctors to develop better strategies to protect the public from melanoma, understanding how different measures of sun exposure history may tell doctors more about this risk for melanoma, and studying the correlation between UV exposure and genetic risk factors may help doctors to know whether UV light might induce genetic changes related to cancer.
    Location: University of Colorado Hospital, Aurora, Colorado

  • Effects of Solar Simulated Light Exposure on Skin Samples from Patients with Metastatic Cancers Treated with Target Therapies

    This pilot clinical trial studies the effects of solar (sun) simulated light exposure on skin sample from patients with melanoma, colon cancer, liver cancer, or thyroid cancer that has spread to other parts of the body (metastatic) treated with target therapies. Therapies known as Raf, mitogen-activated protein kinase kinase (MEK), or protein kinase inhibitors (target therapies) may cause skin side effects such as moles also called melanocytic nevus. Studying the effects of Raf inhibition when given with MEK or protein kinase inhibitors on skin samples before and after solar simulated light exposure may help doctors evaluate changes which occur in the skin of patients undergoing metastatic cancer treatment with Raf.
    Location: The University of Arizona Medical Center-University Campus, Tucson, Arizona

  • Internet-based Intervention for Skin Self-Examination in Participants with Increased Risk for Melanoma

    This trial studies an internet-based intervention for skin self-examination (SSE) in participants with increased risk for melanoma. Early detection of suspicious growths on the skin can be done by performing regular SSE checks. Using an internet-based intervention, such as mySmartCheck, may help to promote regular, thorough checks on the skin in participants with increased risk for melanoma.
    Location: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey