Clinical Trials Using Anti-EGFRvIII/CD3 BiTE Antibody AMG 596

Clinical trials are research studies that involve people. The clinical trials on this list are studying Anti-EGFRvIII/CD3 BiTE Antibody AMG 596. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma

    This is a Phase 1 / 1b Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 596 monotherapy or in combination with AMG 404 in Subjects with Glioblastoma or Malignant Glioma Expressing Mutant Epidermal Growth Factor Receptor Variant III (EGFRvIII). This is a first in human (FIH), open-label, sequential-dose-escalation study in subjects with EGFRvIII-positive glioblastoma or malignant glioma. This study will enroll 2 groups of subjects according to disease stage, recurrent disease (Group 1) and maintenance treatment after SoC in newly diagnosed disease (Group 2).
    Location: 2 locations