Clinical Trials Using Anti-LAG-3 Monoclonal Antibody BMS-986016

Clinical trials are research studies that involve people. The clinical trials on this list are studying Anti-LAG-3 Monoclonal Antibody BMS-986016. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-17 of 17
  • A Study to Test Combination Treatments in People With Advanced Renal Cell Carcinoma

    The purpose of this study is to test the effectiveness and safety of various nivolumab combinations compared to nivolumab and ipilimumab in participants with advanced kidney cancer
    Location: 14 locations

  • An Investigational Immuno-therapy Study to Assess the Safety, Tolerability and Effectiveness of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors

    The purpose of the study is to assess the safety, tolerability and effectiveness of experimental medication BMS-986016 administered alone and in combination with nivolumab in patients with solid tumors that have spread and / or cannot be removed by surgery. The following tumor types are included in this study: Non-Small Cell Lung Cancer (NSCLC), gastric cancer, hepatocellular carcinoma, renal cell carcinoma, bladder cancer, squamous cell carcinoma of the head and neck, and melanoma, that have NOT previously been treated with immunotherapy. NSCLC and melanoma that HAVE previously been treated with immunotherapy.
    Location: 12 locations

  • Anti-LAG-3 Monoclonal Antibody BMS-986016 or Urelumab Alone and in Combination with Nivolumab in Treating Patients with Recurrent Glioblastoma

    This phase I trial studies the safety and best dose of anti-lymphocyte activation gene-3 (LAG-3) monoclonal antibody BMS-986016 or urelumab alone and in combination with nivolumab in treating patients with glioblastoma that has returned (recurrent). Monoclonal antibodies, such as anti-LAG-3 monoclonal antibody BMS-986016, urelumab, and nivolumab may interfere with the ability of tumor cells to grow and spread.
    Location: 13 locations

  • A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma

    The purpose of this study is to determine whether nivolumab in combination with relatlimab is more effective than nivolumab by itself in treating unresectable melanoma or melanoma that has spread
    Location: 13 locations

  • An Investigational Immuno-therapy Study to Investigate the Safety and Effectiveness of Nivolumab, and Nivolumab Combination Therapy in Virus-associated Tumors

    The purpose of this study to investigate the safety and effectiveness of nivolumab, and nivolumab combination therapy, to treat patients who have virus-associated tumors. Certain viruses have been known to play a role in tumor formation and growth. This study will investigate the effects of the study drugs, in patients who have the following types of tumors: - Anal canal cancer-No longer enrolling this tumor type - Cervical cancer - Epstein Barr Virus (EBV) positive gastric cancer-No longer enrolling this tumor type - Merkel Cell Cancer - Penile cancer-No longer enrolling this tumor type - Vaginal and vulvar cancer-No longer enrolling this tumor type - Nasopharyngeal Cancer - No longer enrolling this tumor type - Head and Neck Cancer - No longer enrolling this tumor type
    Location: 10 locations

  • A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer

    The purpose of this study is to determine whether Nivolumab in combination with other therapies is more effective than Nivolumab in combination with Ipilimumab in treating patients / subjects with advanced gastric cancer.
    Location: 11 locations

  • An Investigational Study of Immunotherapy Combinations in Participants With Solid Cancers That Are Advanced or Have Spread

    The purpose of this study is to investigate safety and anti-tumor activity of relatlimab combination therapy in solid cancers that are advanced or have spread
    Location: 4 locations

  • Nivolumab with or without Relatlimab before Chemoradiotherapy in Treating Patients with Operable Stage II-III Esophageal or Gastroesophageal Junction Cancer

    This phase Ib trials studies the side effects of nivolumab with or without relatlimab before chemoradiotherapy in treating patients with stage II-III esophageal or gastroesophageal junction cancer that can be removed by surgery (operable). Immunotherapy with monoclonal antibodies, such as nivolumab and relatlimab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving nivolumab with or without relatlimab prior to current chemoradiotherapy works better in treating patients with esophageal or gastroesophageal junction cancer.
    Location: 4 locations

  • Nivolumab with or without Relatlimab in Treating Advanced Esophageal or Gastric Cancer

    This phase IB trial studies how well nivolumab with or without relatlimab works in treating patients with esophageal or gastric cancer that has spread to other places in the body. Immunotherapy with monoclonal antibodies, such as nivolumab and relatlimab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
    Location: 4 locations

  • An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment

    The purpose of this study is to evaluate the treatment of solid tumors with various immunotherapy combinations. The treatment will be determined based upon a broad biomarker assessment.
    Location: 2 locations

  • Nivolumab and Relatlimab in Treating Patients with Stage IIIB-IV Melanoma

    This phase II trial studies how well nivolumab and relatlimab work in treating patients with stage IIIB-IV melanoma that cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab and relatlimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
    Location: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

  • Nivolumab and Relatlimab or Ipilimumab in Treating Patients with Locally Advanced, Unresectable, or Metastatic Melanoma

    This phase II trial studies how well nivolumab given together with relatlimab or ipilimumab works in treating patients with melanoma that has spread to nearby tissue or lymph nodes, cannot be removed by surgery, or has spread to other places in the body. Immunotherapy with monoclonal antibodies, such as nivolumab, relatlimab, and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
    Location: Vanderbilt University / Ingram Cancer Center, Nashville, Tennessee

  • Nivolumab and Relatlimab in Treating Patients Microsatellite Stable Advanced Colorectal Cancer

    This phase II trial studies how well nivolumab and relatlimab work in treating patients with microsatellite stable colorectal cancer that has spread to other places in the body. Microsatellites are short pieces of genetic materials that are repeated together in a row along the DNA molecule. In some colon tumors the number of microsatellite repeats is different that the number of repeats in the DNA when it was inherited, which might be due to DNA repair defects in these tumors. Microsatellite stable tumors do not have this defect. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Relatlimab may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving nivolumab and relatlimab may work better in treating patients with microsatellite stable colorectal cancer that has spread to other places in the body.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Nivolumab and Relatlimab in Treating Participants with Advanced Chordoma

    This phase II trial studies how well nivolumab and relatlimab work in treating participants with chordoma that has spread to other places in the body. Monoclonal antibodies, such as nivolumab and relatlimab, may interfere with the ability of tumor cells to grow and spread.
    Location: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

  • Nivolumab and Relatlimab in Treating Patients with Locally Advanced or Metastatic Mismatch Repair Deficient Solid Tumors Resistant to Prior PD-L1 Therapy

    This phase II trial studies how well nivolumab and relatlimab work in treating patients with mismatch repair deficient solid tumors that have spread from where they started to nearby tissue or lymph nodes (locally advanced) or other places in the body (metastatic) and are resistant to prior PD-L1 therapy. Immunotherapy with monoclonal antibodies, such as nivolumab and relatlimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Nivolumab with or without Ipilimumab or Relatlimab before Surgery in Treating Patients with Stage IIIB-IV Melanoma That Can Be Removed by Surgery

    This randomized phase II trial studies how well nivolumab with or without ipilimumab or relatlimab before surgery works in treating patients with stage IIIB-IV melanoma that can be removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, and relatlimab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving nivolumab alone or in combination with ipilimumab or relatlimab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
    Location: M D Anderson Cancer Center, Houston, Texas

  • A Study to Assess Safety and Efficacy of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-PD-1 Treatment

    The primary purpose of this study is to characterize the safety, tolerability, and dose-limiting toxicities (DLTs) and to determine the recommended dose of relatlimab in combination with ipilimumab (for dose escalation) and to evaluate the safety, tolerability, and preliminary efficacy of the recommended dose of relatlimab in combination with ipilimumab versus ipilimumab monotherapy (for dose expansion).
    Location: Northwestern University, Chicago, Illinois