Clinical Trials Using Leflunomide
Clinical trials are research studies that involve people. The clinical trials on this list are studying Leflunomide. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Leflunomide in Treating Patients with Previously Treated Metastatic Triple Negative Breast Cancer
This phase I / II trial studies the side effects, best dose and how well leflunomide works in treating patients with previously treated triple negative breast cancer (TNBC) that had spread to other places in the body (metastasis). TNBC is an aggressive form of breast cancer, especially when it is metastatic. Standard chemotherapy often works less well in TNBC than it does in other forms of breast cancer. Leflunomide may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: 3 locations
Leflunomide in Treating Patients with Steroid Dependent Chronic Graft Versus Host Disease
This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow transplant. GVHD occurs when immune cells transplanted from a donor (the graft) recognize the transplant recipient (the host) as foreign, and cause damage to the skin, gastrointestinal tract or other organs. Steroids are the first line of therapy and benefits are seen in about one-third of patients with cGVHD. Prolonged use of steroids is associated with multiple complications. Leflunomide may decrease the body's immune response and reduce inflammation associated with cGVHD.
Location: City of Hope Comprehensive Cancer Center, Duarte, California