Clinical Trials Using Mocetinostat

Clinical trials are research studies that involve people. The clinical trials on this list are studying Mocetinostat. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-2 of 2
  • Pembrolizumab, Guadecitabine, and Mocetinostat in Treating Patients with Stage IIIb-IV Non-small Cell Lung Cancer

    This phase I / Ib trial studies the side effects and best dose of guadecitabine and mocetinostat and how well they work when given together with pembrolizumab in treating patients with stage IIIb-IV non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as guadecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Mocetinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab, guadecitabine, and mocetinostat together may work in treating patients with non-small cell lung cancer.
    Location: 3 locations

  • Mocetinostat and Vinorelbine for the Treatment of Locally Advanced Unresectable or Metastatic, Refractory or Relapsed Rhabdomyosarcoma in Children, Adolescents, and Young Adults

    This phase I / II trial studies the side effects and best dose of mocetinostat when given together with vinorelbine and to see how well it works in treating children, adolescents, and young adults with rhabdomyosarcoma that has spread to nearby tissues or lymph nodes and cannot be removed by surgery (locally advanced unresectable) or has spread to other places in the body (metastatic), and does not respond to treatment (refractory) or has come back (relapsed). Mocetinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving mocetinostat and vinorelbine may work better in treating children, adolescents, and young adults with rhabdomyosarcoma compared to vinorelbine alone.
    Location: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California