Clinical Trials Using Mycophenolate Mofetil

Clinical trials are research studies that involve people. The clinical trials on this list are studying Mycophenolate Mofetil. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 26-50 of 72

  • Donor Stem Cell Transplant in Treating Patients with High Risk Hematologic Malignancies

    This phase II trial studies the how well donor stem cell transplant works in treating patients with high risk hematologic malignancies. Giving total-body irradiation and chemotherapy before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient’s immune cells and help destroy any remaining cancer cells.
    Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

  • Cyclophosphamide and Bendamustine after Donor Bone Marrow Transplant in Preventing GVHD in Patients with Leukemia or Lymphoma

    This phase I / Ib trial studies the side effects and best dose of bendamustine when given together with cyclophosphamide after donor bone marrow transplant and to see how well they work in preventing graft versus host disease (GVHD) in patients with leukemia or lymphoma. Sometimes the transplanted cells from a donor can attack the body's normal cells (called graft-versus-host disease). Giving bendamustine and cyclophosphamide after the transplant may stop this from happening.
    Location: Banner University Medical Center - Tucson, Tucson, Arizona

  • Standard Chemotherapy and Donor Bone Marrow Transplant after Chemotherapy in Treating Patients with Metastatic Castration-Resistant Prostate Cancer

    This pilot phase I clinical trial studies how well donor bone marrow transplant works when given together with standard chemotherapy in treating patients with castration-resistant prostate cancer that has spread to other places in the body. Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving standard chemotherapy and donor bone marrow transplant may work better in treating patients with castration-resistant prostate cancer.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Reduced Intensity Conditioning and Stem Cell Transplant in Treating Patients with Blood Cancer

    This phase II trial studies how well reduced intensity conditioning (a short course of chemotherapy) and stem cell transplant work in treating patients with blood cancer. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient’s immune cells and help destroy any remaining cancer cells. Giving reduced intensity conditioning and total body irradiation before a donor blood stem cell transplant helps to stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells with shorter recovery and fewer side effects.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

  • Fludarabine-Based Conditioning before Donor Bone Marrow Transplant in Patients with Acquired Aplastic Anemia or Inherited Bone Marrow Failure Syndromes

    This trial studies how well fludarabine-based reduced intensity conditioning regimen works in preventing transplant rejection in patients with aplastic anemia or inherited bone marrow failure syndromes scheduled to undergo donor bone marrow transplant. Reduced intensity conditioning involves giving medicines that decrease the amount of white blood cells in the body. These cells support the immune system which fights infection and also help the body identify anything that is new and determine if it needs to get rid of it. Decreasing the amount of white blood cells may help the new bone marrow to get accepted and not be rejected by the body’s immune system.
    Location: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

  • Partially HLA-Mismatched Related Donor Stem Cell Transplant Using Killer Immunoglobulin Receptor and Human Leukocyte Antigen Based Donor Selection in Treating Patients with Hematologic Malignancies

    This pilot clinical trial studies how well partially human leukocyte antigen (HLA)-mismatched related donor stem cell transplant using killer immunoglobulin receptor or HLA based donor selection works in treating patients with hematologic malignancies. Partially mismatched donor stem cells may reduce the risk of cancer recurring after transplant.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York

  • Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating Patients with Blood Cancer Undergoing Donor Stem Cell Transplant

    This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving cyclophosphamide after the transplant may stop this from happening. Once the donated stem cells begin working, the patient's immune system may see the remaining cancer cells as not belonging in the patient's body and destroy them.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Chemotherapy, Total Body Irradiation, Donor Bone Marrow Transplant, and Immunosuppressive Therapy in Treating Patients with Severe Aplastic Anemia

    This phase II trial studies how well chemotherapy, total body irradiation, donor bone marrow transplant, and immunosuppressive therapy work in treating patients with severe aplastic anemia. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy and total-body irradiation before a donor bone marrow transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells called graft-versus-host disease. Giving immunosuppressive therapy, such as tacrolimus and mycophenolate mofetil, after the transplant may stop this from happening. Giving chemotherapy, total body irradiation, donor bone marrow transplant, and immunosuppressive therapy may work better in treating patients with severe aplastic anemia.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Cytokine-Induced Killer Cells after Donor Stem Cell Transplant in Treating Patients with Refractory or Relapsed Acute Myeloid Leukemia

    This phase II trial studies how well cytokine-induced killer cells after donor stem cell transplant work in treating patients with acute myeloid leukemia that has come back or has not responded to treatment. Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving cytokine-induced killer cells after the transplant may stop this from happening.
    Location: Siteman Cancer Center at Washington University, Saint Louis, Missouri

  • Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients with Relapsed or Refractory High-Grade Myeloid Neoplasms

    This clinical trial studies how well early stem cell transplantation works in treating patients with high-grade myeloid neoplasms that has come back after a period of improvement or does not respond to treatment. Drugs used in chemotherapy, such as filgrastim, cladribine, cytarabine and mitoxantrone hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a donor peripheral blood cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient’s immune cells and help destroy any remaining cancer cells. Early stem cell transplantation may result in more successful treatment for patients with high-grade myeloid neoplasms.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Cyclophosphamide, Fludarabine Phosphate, and Total-Body Irradiation with or without Anti-Thymocyte Globulin before Donor Umbilical Cord Blood Transplant in Treating Patients with Hematologic Cancer

    This phase II trial studies the side effects of cyclophosphamide, fludarabine phosphate, and total-body irradiation with or without anti-thymocyte globulin before donor umbilical cord blood transplant and to see how well they work in treating patients with hematologic cancer. Giving chemotherapy and total-body irradiation before donor umbilical cord blood transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving sirolimus and mycophenolate mofetil before and after the transplant may stop this from happening.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

  • Fludarabine, Cyclophosphamide, and Total-Body Irradiation before Donor Stem Cell Transplant in Treating Patients with Blood Diseases

    This phase II trial studies how well fludarabine, cyclophosphamide, and total-body irradiation before donor stem cell transplant work in treating patients with blood diseases. Giving chemotherapy, such as fludarabine and cyclophosphamide, and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient’s immune cells and help destroy any remaining cancer cells.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

  • Abbreviated Mycophenolate Mofetil and Sargramostim after Stem Cell Transplant in Treating Patients with High Risk or Recurrent Hematological Malignancies

    This randomized phase II trial studies how well a shortened course of treatment with mycophenolate mofetil after stem cell transplant works when given with sargramostim in treating patients with a cancer that affects the blood or bone marrow (hematological malignancy), and is at high risk for returning or came back after previous treatment (recurrent). Graft versus host disease (GVHD) is a condition that may occur after transplant, in which the stem cells that are transplanted from a donor (the "graft") attack the normal cells of the patient (the “host”). Mycophenolate mofetil is used to help prevent GVHD after transplants. Giving mycophenolate mofetil for a shorter period of time may help the transplanted cells engraft with the patient's body more quickly, which may help the patient recover after the transplant. After transplants, colony-stimulating factors, such as filgrastim, are also given to help keep the bone marrow working to fight infections until it can recover from the transplant. Sargramostim may be a more effective treatment for supporting the bone marrow function than standard treatment with filgrastim. It is not yet known whether giving abbreviated treatment with mycophenolate mofetil and sargramostim is more effective than longer treatment given with filgrastim in treating patients with high risk or recurrent hematological malignancies after transplant.
    Location: Virginia Commonwealth University / Massey Cancer Center, Richmond, Virginia

  • Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

    Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems. Objective: To see if allogeneic blood or bone marrow transplant is safe and effective in treating people with primary immunodeficiencies. Eligibility: Donors: Healthy people ages 4 or older Recipients: People ages 4-75 with a primary immunodeficiency that may be treated with allogeneic blood or marrow transplant Design: Participants will be screened with medical history, physical exam, and blood tests. Participants will have urine tests, EKG, and chest x-ray. Donors will have: Bone marrow harvest: With anesthesia, marrow is taken by a needle in the hipbone. OR Blood collection: They will have several drug injections over 5-7 days. Blood is taken by IV in one arm, circulates through a machine to remove stem cells, and returned by IV in the other arm. Possible vein assessment or pre-anesthesia evaluation Recipients will have: Lung test, heart tests, radiology scans, CT scans, and dental exam Possible tissue biopsies or lumbar puncture Bone marrow and a small piece of bone removed by needle in the hipbone. Chemotherapy 1-2 weeks before transplant day Donor stem cell donation through a catheter put into a vein in the chest or neck Several-week hospital stay. They will take medications and may need blood transfusions and additional procedures. After discharge, recipients will: Remain near the clinic for about 3 months. They will have weekly visits and may require hospital readmission. Have multiple follow-up visits to the clinic in the first 6 months, and less frequently for at least 5 years.
    Location: National Institutes of Health Clinical Center, Bethesda, Maryland

  • Reduced Intensity Chemotherapy and Radiation Therapy before Donor Stem Cell Transplant in Treating Patients with Hematologic Malignancies

    This clinical trial studies the use of reduced intensity chemotherapy and radiation therapy before donor stem cell transplant in treating patients with hematologic malignancies. Giving low doses of chemotherapy, such as cyclophosphamide and fludarabine phosphate, before a donor stem cell transplant may help stop the growth of cancer cells. It may also stop the patient’s immune system from rejecting the donor’s stem cells. The donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Reducing the intensity of the chemotherapy and radiation may also reduce the side effects of the donor stem cell transplant.
    Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

  • Genetically Modified Donor Stem Cell Transplant Followed by Zoledronic Acid in Treating Younger Patients with Relapsed / Refractory Hematologic Malignancies or High Risk Solid Tumors

    This phase I trial studies the side effects of zoledronic acid given after genetically modified donor stem cell transplant in treating younger patients with hematologic malignancies or high risk tumors that have returned after a period of improvement (relapsed) or do not respond to treatment (refractory). Giving chemotherapy before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When healthy stem cells from a donor that have been genetically modified are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving mycophenolate mofetil and tacrolimus after the transplant may stop this from happening. Giving zoledronic acid after the transplant may help strengthen the immune system and make the immune cells work better.
    Location: University of Wisconsin Hospital and Clinics, Madison, Wisconsin

  • CD8+ Memory T-Cells as Consolidative Therapy after Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients with Leukemia or Lymphoma

    This phase II trial studies how well CD8+ memory T-cells work as a consolidative therapy following a donor non-myeloablative hematopoietic cell transplant in treating patients with leukemia or lymphoma. Giving total lymphoid irradiation and anti-thymocyte globulin before a donor hematopoietic cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving cyclosporine and mycophenolate mofetil after the transplant may stop this from happening. Once the donated stem cells begin working, the patient's immune system may see the remaining cancer cells as not belonging in the patient's body and destroy them. Giving an infusion of the donor's white blood cells, such as CD8+ memory T-cells, may boost this effect and may be an effective treatment to kill any cancer cells that may be left in the body.
    Location: Stanford Cancer Institute Palo Alto, Palo Alto, California

  • Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients with Relapsed Hematologic Cancers Undergoing a Second or above Donor Stem Cell Transplant

    This phase I trial studies the side effects and the best dose of intensity modulated total marrow irradiation (IMTMI) when given together with fludarabine phosphate and melphalan in treating patients with cancers of the blood (hematologic) that have returned after a period of improvement (relapsed) undergoing a second or above donor stem cell transplant. IMTMI is a type of radiation therapy to the bone marrow that may be less toxic and may also reduce the chances of cancer to return. Giving fludarabine phosphate, melphalan, and IMTMI before a donor stem cell transplant may help stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
    Location: University of Chicago Comprehensive Cancer Center, Chicago, Illinois

  • JAK Inhibitor before Donor Stem Cell Transplant in Treating Patients with Primary or Secondary Myelofibrosis

    This phase II trial studies how well giving a JAK inhibitor before a donor stem cell transplant works in treating patients with myelofibrosis that developed without another condition (primary) or evolved from other bone marrow disorders (secondary). JAK inhibitors are a class of drugs that may stop the growth of abnormal cells by blocking an enzyme needed for cell growth. Giving a JAK inhibitor such as ruxolitinib before a donor stem cell transplant may help reduce symptoms of myelofibrosis such as inflammation and enlargement of the spleen, improve the patient’s general physical condition, and prevent complications from occurring after the transplant. Infusing healthy stem cells from a donor into the patient may help the patient's bone marrow work normally and make stem cells, red blood cells, white blood cells, and platelets. Giving a JAK inhibitor before a donor stem cell transplant may help improve transplant outcomes in patients with myelofibrosis.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Donor Stem Cell Transplant Followed by Cyclophosphamide in Treating Patients with Hematological Diseases

    This phase II trial studies donor stem cell transplant followed by cyclophosphamide in treating patients with hematological diseases. Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can attack the body's normal cells, called graft versus host disease. Giving cyclophosphamide after the transplant may stop this from happening.
    Location: Wake Forest University Health Sciences, Winston-Salem, North Carolina

  • Intra-osseous Donor Umbilical Cord Blood and Mesenchymal Stromal Cell Co-transplant in Treating Patients with Hematologic Malignancies

    This clinical trial studies intra-osseous donor umbilical cord blood and mesenchymal stromal cell co-transplant in treating patients with hematologic malignancies. Giving low doses of chemotherapy and total-body irradiation before a co-transplant of donor umbilical cord blood and mesenchymal stromal cells into the bone (intra-osseous) helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving cyclosporine and mycophenolate mofetil at the time of transplant may stop this from happening.
    Location: Case Comprehensive Cancer Center, Cleveland, Ohio

  • Nonmyeloablative Peripheral Blood Stem Cell Transplant in Treating Patients with Hematologic Malignancies

    This pilot phase I trial studies the side effects and how well lower dose (nonmyeloablative) peripheral blood stem cell transplant works in treating patients with hematologic malignancies. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a related donor, that closely match the patient's blood, are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient’s immune cells and help destroy any remaining cancer cells.
    Location: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

  • Partially-Matched Donor Stem Cell Transplant in Treating Younger Patients with High-Risk Hematologic Malignancies

    This pilot clinical trial studies partially-matched donor stem cell transplant in treating younger patients with high-risk hematologic malignancies. Giving chemotherapy and / or total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Giving cyclophosphamide, tacrolimus, and mycophenolate mofetil after the transplant may stop this from happening.
    Location: Lurie Children's Hospital-Chicago, Chicago, Illinois

  • Natural Killer Cells before and after Donor Stem Cell Transplant in Treating Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

    This phase I / II studies the side effects and best dose of natural killer cells before and after donor stem cell transplant and to see how well they work in treating patients with acute myeloid leukemia, myelodysplastic syndrome, or chronic myelogenous leukemia. Giving chemotherapy with or without total body irradiation before a donor peripheral blood stem cell or bone marrow transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells and natural killer cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Ibritumomab Tiuxetan before Donor Peripheral Blood Stem Cell Transplant in Treating Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

    This phase II trial studies how well ibritumomab tiuxetan before donor peripheral blood stem cell transplant works in treating patients with non-Hodgkin lymphoma that has returned or does not respond to treatment. Giving rituximab, antithymocyte globulin, and total-lymphoid irradiation (TLI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells and helps stop the patient's immune system from rejecting the donor's stem cells. Also, radiolabeled monoclonal antibodies, such as ibritumomab tiuxetan, can find cancer cells and carry cancer-killing substances to them without harming normal cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving rituximab, antithymocyte globulin, and TLI before the transplant together with cyclosporine and mycophenolate mofetil after the transplant may stop this from happening. Giving a radiolabeled monoclonal antibody before a donor peripheral blood stem cell transplant may be an effective treatment for non-Hodgkin lymphoma.
    Location: University of California Davis Comprehensive Cancer Center, Sacramento, California