Clinical Trials Using pNGVL4a-Sig/E7(detox)/HSP70 DNA Vaccine

Clinical trials are research studies that involve people. The clinical trials on this list are studying pNGVL4a-Sig/E7(detox)/HSP70 DNA Vaccine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Vaccine Therapy with or without Imiquimod in Treating Patients with High-Grade Cervical Intraepithelial Neoplasia

    This pilot phase I trial studies the side effects and best dose of giving vaccine therapy with or without imiquimod in treating patients with high-grade cervical intraepithelial neoplasia. Vaccines made from deoxyribonucleic acid (DNA) or a gene-modified virus may help the body build an effective immune response to kill tumor cells. Biological therapies, such as imiquimod, may stimulate the immune system in different ways and stop cancer cells from growing. Giving vaccine therapy together with imiquimod may be a better treatment for cervical intraepithelial neoplasia.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland