Clinical Trials Using Porfimer Sodium

Clinical trials are research studies that involve people. The clinical trials on this list are studying Porfimer Sodium. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients with Locally Advanced Lung Cancer

    This early phase I trial studies the side effects of endobronchial ultrasound guided interstitial photodynamic therapy and how well it works in treating patients with lung cancer that has spread to nearby tissues or lymph nodes (locally advanced). Photodynamic therapy consists of injecting a light sensitive drug called a photosensitizer, such as porfimer sodium, into the vein, waiting for it to accumulate in the tumor, and then activating it with a red laser light. Giving photodynamic therapy with porfimer sodium may reduce the tumor size in patients with lung cancer.
    Location: Roswell Park Cancer Institute, Buffalo, New York

  • Porfimer Sodium Interstitial Photodynamic Therapy with or without Standard of Care Chemotherapy in Treating Patients with Locally Advanced or Recurrent Head and Neck Cancer

    This phase I / II trial studies the side effects of interstitial photodynamic therapy and to see how well it works with standard of care chemotherapy in treating patients with head and neck cancer that has spread to other parts of the body (locally advanced) or that has come back (recurrent). Interstitial photodynamic therapy uses a light-sensitive drug called porfimer sodium. This drug is activated by laser light delivered through special fibers into the tumor. It is not yet known how well porfimer sodium interstitial photodynamic therapy works, with or without standard of care chemotherapy, in treating patients with head and neck cancer.
    Location: Roswell Park Cancer Institute, Buffalo, New York

  • Chemotherapy With or Without Porfimer Sodium-Based Photodynamic Therapy During Surgery in Treating Patients With Malignant Pleural Mesothelioma

    This randomized phase II trial studies how well chemotherapy with or without porfimer sodium-based photodynamic therapy during surgery works in treating patients with malignant pleural mesothelioma. Drugs used in chemotherapy, such as pemetrexed disodium, work in different ways to stop the growth of cancer, either by killing the cancer cells, by stopping them from dividing, or by stopping them from spreading. Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed. It is not yet known whether chemotherapy is more effective with or without porfimer sodium-based photodynamic therapy during surgery in treating patients with malignant pleural mesothelioma.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • Light Dosimetry for Photodynamic Therapy with Porfimer Sodium in Treating Patients with Malignant Mesothelioma or Non-small Cell Lung Cancer with Pleural Disease Undergoing Surgery

    This phase I trial studies the side effects and how well light dosimetry system works during photodynamic therapy with porfimer sodium in treating patients with malignant mesothelioma or non-small cell lung cancer with pleural disease undergoing surgery. Light dosimetry measures the amount of laser light given during photodynamic therapy. Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active when it is exposed to light. The activated drug may kill tumor cells. Using light dosimetry for intraoperative photodynamic therapy may help doctors estimate how much light is delivered during photodynamic therapy and decide if the treatment should be stopped or continued.
    Location: Roswell Park Cancer Institute, Buffalo, New York