Clinical Trials Using Smac Mimetic LCL161
Clinical trials are research studies that involve people. The clinical trials on this list are studying Smac Mimetic LCL161. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat
The purpose of this study is to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety, tolerability, pharmacological and clinical activity of these combinations.
Location: 9 locations
LCL161 Plus Topotecan for Patients With Relapsed / Refractory Small Cell Lung Cancer and Select Gynecologic Malignancies
This trial will investigate the combination of two anti-cancer agents to treat patients with relapsed / refractory small cell lung cancer (SCLC) and ovarian cancers. Oral topotecan has US FDA approval for treating select gynecological cancers and SCLC. LCL161 is an investigational product that has been shown in clinical trials to work together with other anti-cancer agents. In this trial, investigators will determine the optimal dose of LCL161 and topotecan to administer to patients with relapsed / refractory SCLC and ovarian cancers, and examine the safety profile of the drug combination.
Location: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
LCL161 in Treating Patients with Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis
This phase II trial studies how well second mitochondrial-derived activator of caspases (SMAC) mimetic LCL161 (LCL161) works in treating patients with primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocytosis myelofibrosis. SMAC mimetic LCL161 may help control the growth of abnormal cells by promoting apoptosis (programmed cell death).
Location: M D Anderson Cancer Center, Houston, Texas
Study of Single Agent CJM112, and PDR001 in Combination With LCL161 or CJM112 in Patients With Multiple Myeloma
The purpose of this study is to assess the safety, tolerability, and identify the recommended doses of single agent CJM112, and of CJM112 or LCL161 in combination with PDR001, in patients with relapsed and / or refractory multiple myeloma.
Location: See Clinical Trials.gov