Clinical Trials Using Vactosertib
Clinical trials are research studies that involve people. The clinical trials on this list are studying Vactosertib. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Vactosertib and Pomalidomide in Treating Patients with Relapsed or Relapsed and Refractory Multiple Myeloma
This phase Ib trial studies the side effects and best dose of vactosertib when given together with pomalidomide in treating patients with multiple myeloma that has come back after treatment (recurrent) or has come back and does not respond to treatment (recurrent and refractory). Vactosertib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Pomalidomide may stop the growth of cancer cells by blocking the growth of new blood vessels necessary for tumor growth. Giving vactosertib and pomalidomide may work better in treating patients with relapsed or relapsed and refractory multiple myeloma.
Location: Case Comprehensive Cancer Center, Cleveland, Ohio
Vactosertib With Durvalumab in Urothelial Carcinoma Failing Checkpoint Inhibition
This is Phase 2, open label, non randomized single arm study to determine whether the administration of vactosertib with durvalumab will provide meaningful increases in the Overall Response Rate (ORR) in patients with urothelial cancers that fail to achieve a response with anti-PD-1 / PD-L1 based regimens
Location: 2 locations