Cancer Moonshot℠ – Funding Opportunities

The funding opportunity announcements (FOAs) listed below highlight research initiatives that align with the efforts of the Cancer Moonshot. They may be supported with existing funds or with the 21st Century Cures funding.

Planning for implementation of longer-term scientific initiatives is also underway. We will continue to update this page as new funding opportunities become available so check back often or sign up to receive automatic email updates on Cancer Moonshot-related activities.

More information about the recently announced funding opportunities is available on the Cancer Moonshot Funding Resources page.

Please note that all publications and data resulting from Cancer Moonshot funded initiatives will be required to be immediately accessible. For more information, see the Cancer Moonshot Public Access and Data Sharing Policy.

Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01)​
Open Funding Opportunity Announcements (FOA)
BRP Recommendation Title Announcement Number Opening Date Expiration Date
Cancer Immunotherapy Translational Science Network Pediatric Immunotherapy-Discovery and Development Network (PI-DDN) (U54) RFA-CA-19-003 11/01/2018 12/18/2018
Pediatric Immunotherapy- Discovery and Development Network (PI-DDN) (U01) RFA-CA-19-004 11/01/2018 12/18/2018
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) PAR-17-245 5/5/2017 5/8/2020
Collaborative Research Projects to Enhance Applicability of Mammalian Models for Translational Research (Collaborative R01) PAR-17-244 5/5/2017 5/8/2020
Metabolic Reprogramming to Improve Immunotherapy (R21) PAR-16-229 9/16/2016 9/8/2019
Metabolic Reprogramming to Improve Immunotherapy (R01) PAR-16-228 9/5/2016 9/8/2019
Prevention and Early Detection: Implementation Science Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01) RFA-CA-19-017 11/10/2018 01/10/2019
Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R01) PAR-16-202 9/11/2016 6/14/2019
Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21) PAR-16-201 9/11/2016 6/14/2019
Dissemination and Implementation Research in Health (R21) PAR-16-236 5/16/2016 5/8/2019
Dissemination and Implementation Research in Health (R01) PAR-16-238 5/10/2016 5/8/2019
Fusion Oncoproteins in Childhood Cancers Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54) RFA-CA-19-016 11/07/2018 12/07/2018
Gene Fusions in Pediatric Sarcomas (R21) PA-16-252 9/16/2016 5/8/2019
Gene Fusions in Pediatric Sarcomas (R01) PA-16-251 9/5/2016 5/8/2019
Generation of Human Tumor Atlases Emerging Questions in Cancer Systems Biology (U01) PAR-16-131 5/24/2016 11/24/2018
High Risk Cancers Communication and Decision Making for Individuals with Inherited Cancer Syndromes (U01) RFA-CA-19-001 12/09/2018 01/09/2019
Closed Funding Opportunity Announcements (FOA)
BRP Recommendation Title Announcement Number
Cancer Immunotherapy Translational Science Network Activities to Promote Research Collaborations on Immune-Related Adverse Events (APRC-irAEs) Associated with Cancer Immunotherapy (Admin Supp) PA-17-248
Canine Immunotherapy Trials and Correlative Studies (U01) RFA-CA-17-001
Coordinating Center for Canine Immunotherapy Trials and Correlative Studies (U24) RFA-CA-17-002
Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies on the Tumor Microenvironment (U01) RFA-CA-17-015
Resource Center for the Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies (U24) RFA-CA-17-016
Cancer Immune Monitoring and Analysis Centers (CIMACs) (U24) RFA-CA-17-005
Cancer Immunologic Data Common (CIDC) (U24) RFA-CA-17-006
Development and Validation of Non-Mouse Reagents to Enable Preclinical Development of Novel Therapeutics (R43/44) PHS2018-1/ Topic 372
Pediatric Immunotherapy Discovery and Development Network (PI-DDN)(U01) RFA-CA-17-051
Pediatric Immunotherapy Discovery and Development Network (PI-DDN)(U54) RFA-CA-17-050
Immuno-Oncology Translation Network (IOTN): Cellular Immunotherapy Data Resource (CIDR) (U24) RFA-CA-17-048
Immuno-Oncology Translation Network (IOTN): Data Management and Resource-Sharing Center (DMRC) (U24) RFA-CA-17-047
Immuno-Oncology Translation Network (IOTN): Cancer Immunoprevention Research Projects (U01) RFA-CA-17-046
Immuno-Oncology Translation Network (IOTN): Cancer Immunotherapy Research Projects (U01) RFA-CA-17-045
Fusion Oncoproteins in Childhood Cancers Administrative Supplements to Promote Research Collaborations on Fusion Oncoproteins as Drivers of Childhood Cancer (Admin Supp) PA-17-138
Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54) RFA-CA-17-049
Generation of Human Tumor Atlases Imaging-Based Tools for Longitudinal and Multi-Dimensional Mapping of the Tumor and its
Microenvironment(R43/R44)
PHS2018-1/ Topic 376
Human Tumor Atlas Network: Data Coordinating Center (U24) RFA-CA-17-036
Pre-Cancer Atlas (PCA) Research Centers (U2C) RFA-CA-17-035
Human Tumor Atlas Research Centers (U2C) RFA-CA-17-034
National Cancer Data Ecosystem PDX Development and Trial Centers (PDTCs) (U54) RFA-CA-17-003
PDX Data Commons and Coordinating Center (PDCCC) for the PDX Development and Trial Centers Research Network (PDXNet) (U24) RFA-CA-17-004
New Enabling Technologies Integration and Validation of Emerging Technologies to Accelerate Cancer Research (R33) RFA-CA-17-023
Computer Aided Decision Support for Radiation Oncology (R43/R44) PHS2018-1/ Topic 380
Diagnostic Imaging for Cancer Immunotherapies (R43/R44) PHS2018-1/ Topic 375
Tools and Technologies for Monitoring RNA Modifications (R43) PHS2018-1/ Topic 373
Activities to Promote Technology Research Collaborations (APTRC) for Cancer Research (Admin Supp) PA-17-143
Prevention and Early Detection: Implementation Science Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01) RFA-CA-17-041
Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS): Coordinating Center (U24) RFA-CA-17-039
Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS)(UG3/UH3) RFA-CA-17-038
Symptom Management Research Bridging the Guideline Implementation Gap: Clinical Decision-Support to Improve Cancer Symptom
Management (R43/R44)
PHS2018-1/ Topic 377
Software Enabling Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients (R43/R44 PHS2018-1/ Topic 379
Analyzing and Interpreting Clinician and Patient Adverse Event Data to Better Understand Tolerability (U01) RFA-CA-17-052
Coordinating Center for Research Centers for Improving Management of Symptoms During and Following Cancer Treatment (U24) RFA-CA-17-043
Research Centers for Improving Management of Symptoms During and Following Cancer Treatment (UM1) RFA-CA-17-042
Therapeutic Target Identification to Overcome Resistance Mechanisms of Cancer Drug Resistance and Sensitivity (U54) RFA-CA-17-009
Mechanisms of Cancer Drug Resistance and Sensitivity: Coordinating Center (U24) RFA-CA-17-044
  • Updated: September 11, 2018

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