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- Don't Miss the Connection: The Role of RAF1 and ROKα in RAS-Driven Cancers
Cancer caused by a mutant KRAS gene is dependent on the presence of one of its downstream effectors, RAF1 (aka CRAF), but not on ARAF or BRAF. Kinase-independent interaction of RAF1 with ROKα accounts for at least some of this dependence.
- Genetic Ablation of KRAS in Pancreas Cancer: When an Essential Oncogene Isn’t
Of all cancers, pancreatic cancers are most dependent on mutant KRAS. However, many pancreatic cancer cell lines survive loss of their mutant KRAS genes. The adaptations these lines make provide opportunities for treating these deadly cancers.