RAS Dialogue
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Top-Down Proteomics Reveals the KRAS Proteoform Landscape in Colorectal CancerMeasuring PTM differences across RAS isoforms and mutants is quite the challenge. Here, the authors discuss how they used top-down proteomics to uncover a diverse RAS proteoform landscape across cancer cell lines and tumor samples.
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Sin1: a novel RAS effector with isoform specificitySin1, a member of the mTORC2 complex, is found to interact preferentially with KRAS4A via an atypical RAS binding domain. This interaction is shown to be dispensable for mTORC2 activity.