RAS Dialogue
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Inhibition of MAPK Signaling Increases Autophagy in Mutant RAS CancersCancers driven by mutant RAS genes show increased autophagy. Dual inhibition of RAS signaling and autophagy inhibits RAS cancers.
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Initiative Spotlight: A Conversation with Frank McCormickRecent discoveries and new approaches are chipping away at the cancers caused by mutant RAS genes. For the first time drugs that target RAS directly are in human clinical trials.
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Conversation with Dr. Shiva Malek and Dr. Christiaan KlijnSignaling downstream of RAS is subject to many levels of regulation. Inhibiting MEK seems to re-wire that regulation so that inhibitors of RAF kinases are more effective against cells driven by mutant KRAS.
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Conversation with Scott Kopetz: RAS in Colorectal Cancer, Initiation and ResistanceMutated RAS genes are an important cause of colorectal cancers, and play a role in resistance to current drug therapies. Remarkably, patients whose cancer is progressing despite treatment often have multiple different RAS mutations in their tumors.
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Combination Screens for Cancer Vulnerabilities: A Conversation with Kris WoodCancers driven by mutant KRAS are difficult to treat. Combining genetic screens with drugs that work downstream of mutant KRAS reveals cellular adaptations to uncontrolled growth that may be targeted.