RAS Dialogue
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Top-Down Proteomics Reveals the KRAS Proteoform Landscape in Colorectal Cancer
Measuring PTM differences across RAS isoforms and mutants is quite the challenge. Here, the authors discuss how they used top-down proteomics to uncover a diverse RAS proteoform landscape across cancer cell lines and tumor samples.
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Sin1: a novel RAS effector with isoform specificity
Sin1, a member of the mTORC2 complex, is found to interact preferentially with KRAS4A via an atypical RAS binding domain. This interaction is shown to be dispensable for mTORC2 activity.
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Simulating Ras: 30 years of progress
Progress in computational simulations of Ras’s movement within lipid bilayers reveal the membrane’s potential directive role on Ras orientation and signaling.
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RAS Initiative Leadership Change
The RAS Initiative welcomes a new Program Officer, Dr. Christopher Kane