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- A Panel of Isogenic RAS-Dependent Cell Lines Developed at the Frederick National Laboratory
Mouse embryonic fibroblasts have been engineered to lack all RAS genes on demand. Then individual RAS genes can be introduced. Such cells allow effects of drugs to be tested with more precision.
- Kras and Cancer Metabolism: A Conversation with Carla Martins
Our cells ordinarily have two copies of each gene, one maternal and one paternal. Cancers in which both KRAS genes are mutated are more aggressive and have different metabolic pathways compared to cancers which have only one mutated KRAS gene.
- Targeting the KRAS G12D Neoantigen to Treat Cancer
The G12D mutation of the oncogene KRAS causes thousands of cancers every year. Steven Rosenberg and colleagues at the National Cancer Institute have treated a patient with metastatic colon cancer by using the patient's own cells to target KRAS G12D.