Because of a lapse in government funding, the information on this website may not be up to date transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at USA.gov.

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

RAS Dialogue

Join the discussion! Post comments, ask questions, and share information with RAS experts. Subscribe to receive notifications when a new RAS Dialogue article is posted.

  • Genetic Ablation of KRAS in Pancreas Cancer: When an Essential Oncogene Isn’t
    January 5, 2018, by Pan-Yu Chen and Mandar Deepak Muzumdar

    Of all cancers, pancreatic cancers are most dependent on mutant KRAS. However, many pancreatic cancer cell lines survive loss of their mutant KRAS genes. The adaptations these lines make provide opportunities for treating these deadly cancers.

    Continue Reading >

  • Glutamine, Cystine, and Cancer Susceptibilities
    October 30, 2017, by Jim Hartley

    The rapid growth of cancer cells generates increased amounts of toxic reactive oxygen species (ROS). Four recent papers show how understanding how cancers deal with ROS can lead to therapeutic opportunities.

    Continue Reading >

  • Ras–dependent Paracrine Cascades
    August 17, 2017, by Kenneth P. Olive

    Most pancreatic cancers are driven by mutant K-Ras genes, and comprise a minority of cancer cells in a densely fibrotic and highly secretory tumor microenvironment. Interrupting the paracrine cascades in pancreatic cancers may improve treatment.

    Continue Reading >

  • RAS and MYC: Co-conspirators in Cancer
    July 13, 2017, by Brittany L. Allen-Petersen and Rosalie C. Sears

    The transcription factor MYC is an important downstream target of mutated RAS genes in human cancers. Inhibiting post-translational modifications of MYC to decrease its transcriptional activity is a new strategy for treating RAS-driven cancers.

    Continue Reading >

  • Powering Off Cancer
    June 9, 2017, by Costas Lyssiotis

    The uncontrolled growth of cancers is dependent on altered metabolism. For example, many cancers are highly dependent on the altered metabolic reactions that occur in their mitochondria. New therapies that target these reactions are being tested.

    Continue Reading >

Archive