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2021 - RAS Dialogue

    • Update: Mutations in Human Cancers Through the Lens of KRAS
      , by Jim Hartley and Ming Yi

      KRAS is the most commonly mutated oncogene in human cancers. Analysis of the mutations in other genes in thousands of human tumors in which KRAS is highly mutated reveals patterns that may guide research into the biology of human cancers.

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    • New Clarity on the Warburg Effect
      , by Alba Luengo, Zhaoqi Li, and Matthew Vander Heiden

      Cancer cells divert glucose from ATP-rich oxidative phosphorylation, to ATP-poor glycolysis, which produces lactic acid as a byproduct. New research is revealing the mechanisms regulating the balance between oxidation and glycolysis.

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