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NCI’s Contributions to the Discovery of Selumetinib for Children with NF1

NCI’s Contributions to the Discovery of Selumetinib for Children with NF1. For 30 years, NCI led and supported basic, translational, and clinical research that culminated in the discovery of selumetinib as the first effective treatment for kids with neurofibromatosis type 1 (NF1) and associated tumors called plexiform neurofibromas (PNs). It started in 1990 with NF1 gene identified and ending in 2020 with FDA granting approval to selumetinib for kids.
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