Stage I Hypopharyngeal Cancer
Stage II Hypopharyngeal Cancer
Stage III Hypopharyngeal Cancer
Stage IV Hypopharyngeal Cancer

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Treatment of stage I hypopharyngeal cancer may include the following:

• Laryngopharyngectomy and neck dissection with or without high- dose radiation therapy to the lymph nodes of the neck.
• Partial laryngopharyngectomy with or without high-dose radiation therapy to the lymph nodes on both sides of the neck.

Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I hypopharyngeal cancer.

Treatment of stage II hypopharyngeal cancer may include the following:

• Laryngopharyngectomy and neck dissection. High- dose radiation therapy to the lymph nodes of the neck may be given before or after surgery.
• Partial laryngopharyngectomy. High-dose radiation therapy to the lymph nodes of the neck may be given before or after surgery.
• Chemotherapy given during or after radiation therapy or after surgery.
• A clinical trial of chemotherapy followed by radiation therapy or surgery.

Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II hypopharyngeal cancer.

Treatment of stage III hypopharyngeal cancer may include the following:

• Radiation therapy before or after surgery.
• Chemotherapy given during or after radiation therapy or after surgery.
• A clinical trial of chemotherapy followed by surgery and/or radiation therapy.
• A clinical trial of chemotherapy given at the same time as radiation therapy.
• A clinical trial of surgery followed by chemotherapy given at the same time as radiation therapy.

Treatment and follow-up of stage III hypopharyngeal cancer is complex and is ideally overseen by a team of specialists with experience and expertise in treating this type of cancer. If all or part of the hypopharynx is removed, the patient may need plastic surgery and other special help with breathing, eating, and talking.

Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III hypopharyngeal cancer.

Treatment of stage IV hypopharyngeal cancer that can be treated with surgery may include the following:

• Radiation therapy before or after surgery.
• A clinical trial of chemotherapy followed by surgery and/or radiation therapy.
• A clinical trial of surgery followed by chemotherapy given at the same time as radiation therapy.

Surgical treatment and follow-up of stage IV hypopharyngeal cancer is complex and is ideally overseen by a team of specialists with experience and expertise in treating this type of cancer. If all or part of the hypopharynx is removed, the patient may need plastic surgery and other special help with breathing, eating, and talking.

Treatment of stage IV hypopharyngeal cancer that cannot be treated with surgery may include the following:

• Radiation therapy.
• Chemotherapy given at the same time as radiation therapy.
• A clinical trial of radiation therapy with chemotherapy.

Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage IV hypopharyngeal cancer.

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