2018 - CCG Updates & Insights
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Meticulous Reconstructions of Tumor Origins With Single-Cell DNA Sequencing: Researcher Interview with Nicholas NavinDr. Nicholas Navin talks about single-cell DNA sequencing and his research, considerations for working in the single-cell sequencing space, and what’s next for his lab.
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ATAC-seq on TCGA: Insights Into the Noncoding Region in Primary CancersResearchers used ATAC-seq to profile the chromatin accessibility of 410 TCGA samples representing 23 primary cancers. The study uncovered a vast number of novel DNA regulatory elements and their potential roles in cancer development, prognosis, and response to therapy.
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Getting to Know the Complexities of Cancer: A 2018 TCGA Symposium PreviewAt the 2018 Cell Symposium, TCGA Legacy: Multi-Omic Studies in Cancer, cancer genomics experts will discuss the latest research in molecularly characterizing cancer, classifying the disease, and the development of targeted therapy. A preview of how some researchers are starting to understand the complex and dynamic aspects of cancer.
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Finding Pediatric Cancer Genomic Data through PGDIThe Pediatric Genomic Data Inventory (PGDI), developed by the Office of Cancer Genomics (OCG), is a new public resource informing researchers how and where to access globally generated pediatric cancer genomic datasets. Connecting researchers with data and fostering collaborations is key to furthering our understanding of childhood cancers.
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From Ignoring Features to Machine Learning Features: Computational Biology Then and NowDr. John Weinstein discusses progress in computational biology over the 12-year span of TCGA. The field has expanded greatly, with researchers taking on more complex problems and trying different approaches.
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The Genomic Data Commons Turns 2: Progress in Clinical Tool DevelopmentThe Genomic Data Commons (GDC) launched two years ago with the goal to build a collaborative, interactive knowledge system that anyone can use. Dr. Lou Staudt reflects on milestones reached at the GDC’s two year anniversary and challenges ahead in building clinically relevant tools and advancing precision medicine.
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After TCGA: Building Clinical Genomic ResourcesThe Center for Cancer Genomics (CCG) continues to build genomic resources with a special focus on clinical features and patient outcome. A new wave of cancer characterization projects will generate data relevant for precision medicine and build on the legacy left by The Cancer Genome Atlas, which officially concluded in April 2018.
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Office of Cancer Genomics: Integration of Structural, Functional, and Computational Genomic Data Advances Precision OncologyA collaborative study conducted by two Office of Cancer Genomics (OCG) initiatives highlights the importance of integrating structural and functional genomics programs to improve cancer therapies, and more specifically, contribute to precision oncology treatments for children.
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Recommended Reads in Cancer GenomicsCCG Director, Dr. Louis M. Staudt and The Cancer Genome Atlas Director, Dr. Jean Claude Zenklusen pick their favorite books and review articles related to cancer genomics.
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Planning a Genomic Characterization Study? Tips for Collecting and Processing BiospecimensThe Biospecimen Core Resource (BCR) collects patient samples and readies them for genomic characterization, analysis, and other downstream steps. The CCG, which has managed the BCR for over a decade for use by The Cancer Genome Atlas and other projects, offers tips for researchers who may be planning their own genomic characterization study.