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NCI Director’s Innovation Award Past Recipients

The NCI Director’s Innovation Award Program is designed to support development of highly innovative approaches and technology aimed at significant cancer-related problems. Novel proposals with the potential for high impact, the potential to generate new intellectual property or technology, or which are considered too high-risk or preliminary to pursue within the base budget allocation are encouraged. Proposals with an emphasis on health disparities research are also encouraged. The program offers one-time awards Career Development Awards that are targeted to Postdoctoral Fellows, Staff Scientists, and Staff Clinicians at all levels, with an upper limit of $10,000.

2019 Director's Innovation Award Recipients - Career Development

Jiangdong Chen, Laboratory of Molecular Biology
Mechanistic insight into an N-acetyltransferase regulating sRNA function

Christina Fitzsimmons, Laboratory of Cell Biology
Linking fumarate and gene expression in renal cell carcinoma

Berkley Gryder, Genetics Branch
Cruciform DNA Adds Critical Signal-Relay Decision Layer to Gene Control 

Stephanie Harmon, Molecular Imaging Program
Automated identification of adverse features on digital pathology and MRI 

Sri Krishna, Surgery Branch
Immune correlates of successful adoptive T-cell therapy 

Jyoti Roy, Molecular Imaging Program
Preservation of salivary gland function after PSMA radionuclide therapies 

Rushikesh Sable, Pediatric Oncology Branch
Precision targeting of M2-like tumor associated macrophages

Varun Sood, Laboratory of Receptor Biology and Gene Expression 
Investigating the determinants of enhancer-promoter interactions 

Yongjun Sui, Vaccine Branch 
Epigenetic programming of myeloid cells and trained immunity in HIV vaccine

Yihan Wan, Laboratory of Receptor Biology and Gene Expression
Orchestrated single-cell transcription dynamics during cell fate decision

2018 Director's Intramural Innovation Award Recipients - Career Development

Tomer Cooks, Laboratory of Human Carcinogenesis 
Precision medicine tools to identify cell-specificity of tumor exosomes 

Qiong Fu, Thoracic and Gastrointestinal Oncology Branch
Identifying novel function of platelets in NAFLD-promoted HCC development 

Chorong Han, Lymphoid Malignancies Branch
Zebrafish as a model for erythroid disorders caused by THRA gene mutations 

Bau-Lin Huang, Cancer and Developmental Biology Laboratory
Gene expression signatures of mouse embryo limb mesenchymal progenitors 

Joe Matarlo, Molecular Targets Laboratory
Natural Product Modulators of miR-21: Implications in Cancer Stem Cells 

Carla Neckles, Genetics Branch
Novel rG4 HNRNPH1-directed Aptamers as Splicing Modulators in Cancer

Eva Perez Guijarro, Laboratory of Cancer Biology and Genetics
In vivo CRISPR/Cas9 screening for novel targets for melanoma immunotherapy 

Leonid Serebryannyy, Laboratory of Receptor Biology and Gene Expression 
Identify molecular pathways of micronuclei formation

David Sturgill, Laboratory of Receptor Biology and Gene Expression 
Base resolution mapping of acetylated cytidine in mRNA 

Leila Toulabi, Laboratory of Human Carcinogenesis 
Mechanistic Investigation of DRD1 EGFR as a Novel Signaling Axis in Lung Cancer 

Scott Walsh, Chemical Biology Laboratory
Rebuilding T cells for Cancer Immunodeficiencies using the IL-7 Pathway 

Li Xia, Chemical Biology Laboratory
Engineer anti-carbohydrate antibody using multivalent display platform 

Acong Yang, Radiation Biology Branch
Identification of Target-Specific Small Molecule Inhibitors of miR-155

2017 Director's Intramural Innovation Award Recipients - Career Development

Fardokht Abulwerdi, Basic Research Laboratory
Triple helix-containing long noncoding RNA, MALAT1, as a therapeutic target

Xavier Bofill De Ros, Gene Regulation and Chromosome Biology Laboratory
Design of a single tool for DNA editing and RNA interference

David Calabrese, Chemical Biology Laboratory
Precise Control of MYC Transcription via Light Mediated Azobenzene Linkers

Andres Canela, Laboratory of Genome Integrity
Physiological role of DNA breaks at neuronal promoters

Jiandong Chen, Laboratory of Molecular Biology
Novel mechanism of sRNA regulation in bacteria 

Austin Duffy, Thoracic and GI Oncology Branch
Precision Immunotherapy for gastric cancer

Ying Fu, Laboratory of Molecular Biology
Glypican-3 Specific Antibody Drug Conjugates for Hepatocellular Carcinoma

Daniel Green, Womens Malignancies Branch
Generation of Continuous 3-D Cultures of Primary Ovarian Cancer Cells

Maria Hernandez, Laboratory of Human Carcinogenesis
Identification of viral-host signatures linked to early onset of HCC

Nan Li, Laboratory of Molecular Biology
Glypican2 as a New Therapeutic Target in Neuroblastoma

Helen Michael, Laboratory of Cancer Biology and Genetics
Identification of genes involved in initiation and transformation of moles

Carter Mitchell, Molecular Targets Laboratory
Anti-Cancer Proteins: A Novel Paradigm to Fight the Ancient Battle

Colin Paul, Laboratory of Cell Biology
Intravital Characterization of Early Metastatic Colonization

Vivek Shukla, Thoracic and GI Oncology Branch
Identification of Novel Targets for Lung Cancer Therapy Using an iPSC Model

Dionysios Watson, Vaccine Branch
“Trojan macrophages” for tumor homing and local delivery of immunotherapy 

2016 Director's Intramural Innovation Award Recipients - Career Development

Songjoon Baek, Ph.D., Laboratory of Receptor Biology and Gene Expression
Identification of a Comprehensive Biomarker of Bladder Cancer Prognosis

Kate Brown, Ph.D., Thoracic and Gastrointestinal Oncology Branch
Targeting P53-Mutant Onco-Metabolism for Treatment of Esophageal Cancers

Ritu Chaudhary, Ph.D., Genetics Branch
Mechanism of Biogenesis and Function of p53-Regulated Circular RNAs

Hien Dang, Ph.D., Laboratory of Human Carcinogenesis
Oncogenic Activation of Nonsense-Mediated Decay in Hepatocellular Carcinoma

Alexander Gorka, Ph.D., Chemical Biology Laboratory
Interrogating the Cancer-Microbiome Link by Site-Specific Manipulation

Edward Kim, Ph.D., Laboratory of Molecular Biology
Mechanistic Insights to Curvature-Driven Localization of a Membrane Protein

Daniel Lee, M.D., Laboratory of Human Carcinogenesis
Role of Squalene Monooxygenase in Breast Cancer Progression

Christophe Marchand, Ph.D., Developmental Therapeutics Branch
High-Throughput Discovery of Human Topoisomerase III Inhibitors

Hidetaka Ohnuki, Ph.D., Laboratory of Cellular Oncology
A New Genome-wide Method of Single Cell Analysis for Histone Modifications

Ana Robles, Ph.D., Laboratory of Human Carcinogenesis 
Methylation of Circulating Tumor DNA as Early Stage Lung Cancer Biomarker

Sanja Stevanovic, Ph.D., Experimental Transplantation and Immunology Branch
High-Throughput Discovery of New Targets for Human Papillomavirus+ Cancers

Karol Szczepanek, Ph.D., Laboratory of Cancer Biology and Genetics
Identification of Breast Cancer Metastasis Promoting Gene Signatures

Casmir Turnquist, Ph.D., Laboratory of Human Carcinogenesis
p53 Isoforms as a Therapeutic Target for Neurodegeneration and “Chemobrain”

Diego Vargas-Inchaustegui, Ph.D., Vaccine Branch
Study of Vaccine-Mediated Development of Antigen-Specific TFH Cell Memory

Lyuba Varticovski, M.D., Laboratory of Receptor Biology and Gene Expression
Computational Analysis Linking Gene Expression to DHS-Identified Enhancers

Jonathan Weiss, Ph.D., Cancer and Inflammation Program
Regulation of Tumor and Immune Metabolism

2015 Director's Intramural Innovation Award Recipients - Career Development

Erin Anderson, Ph.D., Chemical Biology Laboratory
"Shielded" Cyanines: Ultra Stable Near-IR Fluorophores

Thorsten Demberg, Ph.D., Vaccine Branch
Evaluation and Isolation of Viable Antigen-Specific Plasma Cells

Majda Haznadar, Ph.D., Laboratory of Human Carcinogenesis
Evaluation of Urinary Metabolomic Lung Cancer Risk Markers

Robert Kortum, Ph.D., Laboratory of Cell and Developmental Signaling
Therapeutic Targeting of B-Raf/C-Raf Heterodimerization

Andrea Kravats, Ph.D., Laboratory of Molecular Biology
Mechanistic Insight into Client Protein Remodeling by the Hsp90 Chaperone

Rhushikesh Kulkarni, Ph.D., Chemical Biology Laboratory
Chemical Rescue of Protein Acetylation in CBP/EP300 Mutant Lymphoma

Chih-Shia Lee, Ph.D., Laboratory of Cancer Biology and Genetics
A Combinatorial RNAi Screen to Systematically Dissect RAS Pathway Addiction

Tineke Lenstra, Ph.D., Laboratory of Receptor Biology and Gene Expression
High Throughput Screen for Epigenetic Regulators of Heterogeneity

Ritankar Majumdar, Ph.D., Laboratory of Cellular and Molecular Biology
In Vivo Biosensors to Map the Spatiotemporal Localization of Leukotriene B4

Scott Medina, Ph.D., Chemical Biology Laboratory
Ultrasound-Triggered Peptisome Nanoparticles for Targeted Antibody Delivery

Helen Michael, Ph.D., Laboratory of Cancer Biology and Genetics
Genomic Profiling of Initiation/Progression of Early Melanocytic Lesions

Sin Man Ng, Ph.D., Vaccine Branch
Novel Adoptive Transfer Therapy Using Chimeric Cytokine Receptors

Sigal Shachar, Ph.D., Laboratory of Receptor Biology and Gene Expression
Identification of lncRNAs Involved in Higher Order Genome Organization

Eric Sterner, Ph.D., Chemical Biology Laboratory
Novel Antibody Design Strategy for Enhanced Cancer Specificity

Joanna Sztuba-Solinska Ph.D., Basic Research Laboratory
Deciphering Structural Features of lncRNAs

Jian Wang, Ph.D., Laboratory of Human Carcinogenesis
Nitric Oxide Mediated Epigenetic Alterations in Pancreatic Cancer

Chuanjin Wu, Ph.D., Dermatology Branch
Targeting Claudin Endocytosis and Degradation to Treat Congenital Tufting Enteropathy

Jason Chang Yi, Ph.D., Laboratory of Cellular and Molecular Biology
Developing a Multiplexed Ultra-High Resolution Imaging Technique

Linda Zane, Ph.D., Laboratory of Receptor Biology and Gene Expression
Oncogenic Transformation and Aging 

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