RAS Initiative Events
A key feature of the RAS Initiative’s ‘hub-and-spokes' model is to serve as an organizing force within the RAS community, promoting the exchange of information and bringing together leaders in the field to help quicken the pace of discovery. The RAS Initiative regularly hosts a symposium, and has held a number of targeted workshops in efforts to achieve this aim.
RAS Initiative Symposium
The first RAS Initiative Symposium, held on December 15-16, 2015, attracted approximately 550 researchers to the FNLCR. The primary objective of this interactive forum was to mobilize the cancer research community towards finding therapeutic solutions to RAS-driven cancers. Since then, subsequent meetings have drawn thousands of researchers from government, industry, and academic institutions worldwide to discuss topics ranging from structural biology to novel therapeutic approaches. The meetings feature invited presentations, short presentations from selected abstracts, and poster presentations.
Fourth RAS Initiative Symposium
Monday - Wednesday, October 17 - 19, 2022, Frederick, Maryland, USA
Third RAS Initiative Symposium
Monday - Wednesday, May 24 - 26, 2021, virtual conference
Second RAS Initiative Symposium
Wednesday - Friday, December 6 - 8, 2017, Frederick, Maryland, USA
First RAS Initiative Symposium
Tuesday - Wednesday, December 15 – 16, 2015, Frederick, Maryland, USA
The following workshops engaged the wider community in tackling targeted questions in RAS biology, and shared knowledge acquired by our diverse team of scientists.
- RAS Structure and Dynamics in Membranes Workshop
October 20, 2016
The RAS Initiative is cooperating with the Department of Energy to model how RAS molecules interact with membranes. This workshop brought together outside membrane protein experts, DOE computational biologists, and RAS Initiative researchers to coordinate efforts to better understand, and possibly drug, RAS-membrane interactions.
- Fully Processed KRAS Protein Purification Workshop
May 16-17, 2016
The RAS Initiative published a procedure for purifying fully processed KRAS-4b protein from insect cells. This workshop brought interested scientists to the FNLCR to learn the key steps of the purification procedure to apply them to their own RAS research.
- RAS Initiative Small Business Workshop
February 25, 2016
The NCI SBIR program solicits applications from small businesses to develop new tools to diagnose and treat cancer. A workshop gathered technical directors from small businesses to describe how their organizations are developing tools that could advance the study of RAS biology or the development of RAS-related therapeutics.
- Synthetic Lethality Network Principal Investigators Meeting
December 14, 2015
The National Cancer Institute has established a network of six laboratories to screen cancers driven by RAS genes for unique vulnerabilities. The directors of these labs met to exchange observations and discuss progress.
- RAS Immunotherapy Workshop
November 3, 2015
Immunotherapies harness the body's own immune system to fight cancer, and are among the most advanced cancer therapies today. This workshop developed as a follow-up to the workshop held on July 23, 2014. The main focus was to assess past and current efforts, and to identify knowledge gaps and strategies for future development of immunotherapies towards KRAS-driven cancers.
- Biophysical and Structural Analysis of Processed KRAS
July 21-22, 2015
RAS molecules must be modified to reach the cell membrane before they can signal to the rest of the cell, either normally or abnormally. Our main goals are to evaluate state-of-the-art techniques and approaches that could be used to gain biophysical and structural insight into membrane-associated protein complexes containing fully modified (farnesylated, methylated) KRAS.
- Identifying Targets for Antibody, Nanoparticle, or Immune System Attack on KRAS Mutant Tumors
July 23, 2014
Targets for many powerful anti-cancer therapies must be unique to or enriched on the surface of cancer cells. This workshop sought advice on how to identify and best utilize cell surface targets on mutant RAS-expressing cancer cells.
- RAS Pathway Modeling and Quantitative Measurements
June 11, 2014
Participants at the KRAS Synthetic Lethality Workshop appreciated that new methods were being developed to analyze perturbed pathways in tumors, in various culture model systems, and in single cells. This workshop was held to learn about the state of the art tools so that we might develop quantitative methods to measure and model perturbations in the RAS pathway.
- KRAS Synthetic Lethality Workshop
January 8 - 9, 2014
Synthetic lethality screens identify vulnerabilities that are inherent in cancers but not normal tissues. Past screens had very limited success in identifying drug targets. This workshop focused on “next generation” screens using new technologies, 3D cell culture, and in vivo systems. Input from this workshop resulted in the formation of the Synthetic Lethality Network to attack cancers driven by mutant KRAS, and the NCI has awarded 4-year grants to six teams.