RAS Meetings and Videos
Upcoming Seminars, Workshops, and Conferences
Sunday - Wednesday, March 5 - 8, 2023, Philadelphia, Pennsylvania
4th RAS-Targeted Drug Development Summit
Monday - Thursday, September 26 - 29, 2022, Boston, Massachusetts, USA
Fourth NCI RAS Initiative Symposium
Monday - Wednesday, October 17 - 19, 2022, Frederick, Maryland, USA
Previous Seminars, Workshops, and Conferences
The Regulation and Function of Small GTPases
Sunday - Friday, June 12 - 17, 2022, Saxtons River, Vermont, USA
AACR Virtual Special Conference: Pancreatic Cancer
Wednesday - Thursday, September 29 - 30, 2021 virtual conference
7th International RASopathies Symposium
Friday - Sunday, July 23 - 25, 2021, virtual conference
Third NCI RAS Initiative Symposium
Monday - Wednesday, May 24 - 26, 2021, virtual conference
RAS-Targeted Drug Discovery
Tuesday – Thursday, February 23 – 25, 2021, virtual conference
Precision medicine for RAS pathway mutations in cancer
Tuesday – Wednesday, December 8 – 9, 2020, virtual conference
Pancreatic Cancer: Advances in Science and Clinical Care
Friday - Monday, September 6-9, 2019, Boston, USA
6th International RASopathies Symposium
Friday - Sunday, August 2-4, 2019, Baltimore, USA
The Regulation and Function of Small GTPases
Sunday - Friday, June 23-28, 2019, Olean, New York, USA
The RAS Superfamily and Related Pathways in Health and Disease
Thursday - Friday, May 16-17, 2019, Santander, Cantabria, Spain
RAS Initiative Report at AACR Annual Meeting
Monday, April 1, 2019, Atlanta, Georgia, USA
Targeting RAS-Driven Cancers
Sunday - Wednesday, December 9-12, 2018, San Diego, USA
5th NCI Pancreatic Cancer Symposium
Tuesday - Wednesday, October 2-3, 2018, Bethesda, Maryland, USA
Frontiers in RAS Pathobiology and Drug Discovery
Thursday - Sunday, September 13-16, 2018, Stratton, Vermont, USA
Small G Proteins in Cellular Signaling and Disease
Monday - Thursday, July 9-12, 2018, Cambridge, UK
Second RAS Initiative Symposium
December 6 - 8, 2017, Frederick, Maryland USA
Videos and Recorded Webcasts
Dr. Frank McCormick, "History of Biology and Medicine Series: RAS Proteins in Human Disease"
As part of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins's History of Biology and Medicine lecture series, Dr. Frank McCormick summarizes four decades of RAS research and explains the role of RAS proteins in human diseases.
Dr. Pasi A Jänne, "A phase 1 clinical trial evaluating the pharmacokinetics (PK), safety, and clinical activity of MRTX849, a mutant-selective small molecule KRAS G12C inhibitor, in advanced solid tumors"
Dr. Pasi A Jänne presents clinical trial data of MRTX849, which specifically targets KRAS G12C mutant tumors.
Dr. Alan Ho, "Preliminary results from a phase 2 trial of tipifarnib in squamous cell carcinomas (SCCs) with HRAS mutations"
Dr. Alan Ho discusses clinical trial data of tipifarnib, a drug that targets HRAS
Dr. Frank McCormick, "The RAS Initiative on National Public Radio"
The NCI RAS Initiative was featured on National Public Radio on March 9, 2018. Photo credit: Richard Harris/NPR Used with permission.
Dr. Frank McCormick, "The NCI RAS Initiative at the Frederick National Laboratory for Cancer Research"
At the Annual Meeting of the American Association for Cancer Research, Frank McCormick, leader of the NCI RAS Initiative, summarizes recent RI activities.
Dr. Bert Vogelstein, "The Road to Cancer Cures - Discover, Predict, Prevent, and Treat"
Bert Vogelstein reflects on why we can cure cancer in mice but not so well in people, and on the sources of mutations in cancer.
Dr. Charles Sawyers, "New Twists on Cancer Drug Resistance"
As drugs that attack RAS directly become available, cancers will inevitably develop resistance. What Charles Sawyers tells us about resistance mechanisms in prostate cancer gives us hope that resistance to RAS therapies can be overcome.
Dr. Frank McCormick, "Targeting K-Ras Induced Stem-ness"
Dr. Frank McCormick, UCSF, describes recent progress in understanding of connections between KRAS and stem-ness. June 11, 2015, at the National Cancer Institute, Frederick, Maryland.
Free videos from the 2015 AACR Annual Meeting
All the scientific presentations from the 2015 Annual Meeting of the American Association for Cancer Research in Philadelphia, USA that are available for viewing without charge may now be found on the AACR web site.
Dr. Matt Holderfield of the Frederick National Lab describes the development of multiple drug screening platforms targeting KRAS in the NCI RAS Initiative. April 21, 2015 at the AACR Annual Meeting, Philadelphia, USA.
How Do the Mutations Underlying Cancers Arise?
Dr. Michael Stratton of the Welcome Trust Sanger Institute, Cambridge, UK describes new insights into the mutational processes that drive cancers. (Dr. Stratton's sciencific remarks begin five minutes into the video.) April 19, 2015 at the AACR Annual Meeting, Philadelphia USA.
Demystifying Medicine 2015 - RAS: A Cancer Mechanism and Target
Dr. Susan Bates of the NCI's Developmental Therapeutics Branch and Dr. Frank McCormick, science advisor to the NCI RAS Initiative, describe the impact of RAS mutations on human health, and new information on regulation of RAS signaling. February 10, 2015 at the National Cancer Institute, Bethesda, Maryland
Dr. Mariano Barbacid, "Targeting K-RAS Driven Cancer"
Dr. Mariano Barbacid of the Centro Nacional de Investigaciones Oncologicas in Madrid, Spain describes how engineered mouse models are being used to understand the role of KRAS in human cancers. November 12, 2014, at the Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland
Dr. Cyril Benes, "Identification of Drug Response Predictors and Therapeutic Strategies by High-Throughput Cell Line Screening"
Dr. Cyril Benes of Massachusetts General Hospital and Harvard Medical School describes his lab's efforts to correlate genotypes and other molecular data with drug sensitivities in hundreds of cell lines derived from human tumors. October 17, 2014, at the Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland
2014 RAS Symposium Presentations
The following ten presentations were presented at the symposium "Targeting RAS Now for Future Cancer Therapy," held at the University of California, San Francisco (UCSF), June 19 and 20, 2014
Symposium 2014: Targeting RAS Now for Future Cancer Therapy – Introduction
Dr. Frank McCormick, Director of the UCSF Cancer Center and advisor to the RAS Initiative at FNLCR, describes what we do not know about RAS-driven cancers.
Symposium 2014: Targeting KRAS Directly and Indirectly
Dr. Stephen W. Fesik, Vanderbilt-Ingram Cancer Center, describes how fragment-based methods can be applied to trying to drug the undruggable.
Symposium 2014: Targeting Mutant KRAS with Small Molecules
Dr. Kevan Shokat, UCSF, describes how his group developed a small molecule that directly targets a KRAS mutant found in many human cancers.
Symposium 2014: Merlin/NF2 Inhibits RAS Tumorigenesis Through YAP
Dr. James A. Fagin, Memorial Sloan Kettering, describes mechanisms underlying signaling downstream of RAS proteins.
Symposium 2014: Inhibitors of Interactions between BRAF and CRAF in KRAS Cancers
Dr. Deborah Morrison, NCI, describes inhibitors of RAF-RAF dimerization.
Symposium 2014: Finding vulnerabilities in cells dependent on mutant KRAS
Dr. Julian Downward, the Cancer Research UK London Institute, describes interactions between PI3K and KRAS, synthetic lethal screens, and circulating tumor DNA.
Symposium 2014: Limits to Tolerance of Increased RAS Signaling in Cancer
Dr. Kevin Shannon, UCSF, describes how dominant oncogenes, Notch and KRAS, are down-regulated in drug-resistant leukemias.
Symposium 2014: Tumor heterogeneity in cancer drug response, resistance, and relapse
Dr. Erica Jackson, Genentech, describes enrichment of cells with stem cell markers in populations of lung cancer cells.
Symposium 2014: The Role of NF1 Loss in Lung and Pancreatic Cancer
Dr. Eric Collisson, UCSF, describes genomics and patient studies that highlight the role of NF1 loss in human cancers.
Symposium 2014: New targets and tools to attack KRAS cancers
Dr. Frank McCormick, science advisor to the RAS Initiative at FNLCR, describes work in his lab at UCSF to develop new tools and identify new targets relevant to KRAS cancers.
Dr. Frank McCormick, "New Targets on the RAS Pathway"
Dr. Frank McCormick describes recent experiments to understand KRAS signaling in cancer at the AACR Annual Meeting, April 5, 2014, San Diego, California USA
Structural Aspects of RAS GTPases
Dr. Alfred Wittinghofer, "GTP-binding Proteins as Molecular Switches", Part 1
Dr. Alfred Wittinghofer explains how solving the three-dimensional structure of RAS and other G-proteins allowed him to understand the conserved mechanism by which G-proteins can act as switches. June 19, 2011
Dr. Alfred Wittinghofer, "GTP-binding Proteins as Molecular Switches", Part 2
In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. June 19, 2011