RAS Tools and Resources
The following are helpful RAS datasets, tools, and resources which we will keep up-to-date. Please email any additional datasets, tools, or resources to SolveRAS@nih.gov and we will add them to the list. The more collaboration we have, the better our chances of solving the challenging RAS problem.
Databases with RAS Information
- GENIE (Genomics Evidence Neoplasia Information Exchange)
AACR Project GENIE is a publicly accessible international cancer registry of real-world data assembled through data sharing between 19 of the leading cancer centers in the world. For more information on how to access data, click here
- The International Cancer Genome Consortium (ICGC)
The International Cancer Genome Consortium (ICGC) is a global initiative to build a comprehensive catalog of mutational abnormalities in the major tumor types
- The Pan-Cancer Analysis of Whole Genomes (PCAWG)
The Pan-Cancer Analysis of Whole Genomes (PCAWG) study is an international collaboration to identify common patterns of mutation in more than 2,600 cancer whole genomes from the International Cancer Genome Consortium
- Clinical Proteomic Tumor Analysis Consortium (CPTAC)
The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics.
Search for changes in growth, drug sensitivity, and co-dependencies in hundreds of cell lines when genes are knocked out or down.
- Protein Databank
Protein Databank contains RAS structures.
GeneCards is a searchable, integrated database of human genes that provides comprehensive, updated, and user-friendly information on all known and predicted human genes.
- Genomics of Drug Sensitivity in Cancer
This project is a collaboration between the Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is funded by the Wellcome Trust.
- The Cancer Genome Atlas (TCGA)
The TCGA Data Portal provides a platform for researchers to search, download, and analyze datasets generated by the TCGA program. It contains clinical information, genomic characterization data, and high level sequence analysis of the tumor genomes.
- Cancer Cell Line Encyclopedia (CCLE)
The CCLE project at the Broad Institute and is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.
- COSMIC - Catalog of Somatic Mutations in Cancer
COSMIC stores and displays somatic mutation information and related details and contains information relating to human cancers.
- Center for Biomedical Informatics & Information Technology (CBIIT)
CBIIT accelerates cancer research by empowering scientists and clinicians with the data and tools they need to drive their research. CBIIT partners with NCI programs and cancer researchers to meet the informatics, data, and information technology needs of the community today.
The cBioPortal for Cancer Genomics provides visualization, analysis, and download of large-scale cancer genomics datasets. The portal is developed and maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center.
Press Releases and News Articles
- RAS at 40: Update from the RAS Initiative
- Chapter One – A brief history of RAS and the RAS Initiative
- The 30-year Quest to Tame The "Wily" Cancer Gene
- Drug Developers Refocus Efforts on RAS
- NCI Advisory Boards Give Green Light to RAS Initiative
- U.S. National Cancer Institute’s New RAS Project Targets an Old Foe