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National CryoEM Facility Acknowledged User Publications

The National Cryo-Electron Microscopy Facility (NCEF), which began operation in May 2017, provides cancer researchers access to the latest cryo-EM technology for high resolution imaging. Publications that report macromolecular structures obtained using data collected at NCEF are listed below.

  • Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii
    McGoldrick LL, Singh AK, Demirkhanyan L, Lin TY, Casner RG, Zakharian E, Sobolevsky AI
    Nat Commun. 2019
    PubMed ID: 31519888
  • Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump
    Su CC, Morgan CE, Kambakam S, Rajavel M, Scott H, Huang W, Emerson CC, Taylor DJ, Stewart PL, Bonomo RA, Yu EW
    MBio. 2019 
    PubMed ID: 31266873
  • Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs
    Hughes SA, Wang F, Wang S, Kreutzberger MAB, Osinski T, Orlova A, Wall JS, Zuo X, Egelman EH, Conticello VP
    Proc Natl Acad Sci U S A. 2019
    PubMed ID: 31262809
  • Regulatory switch at the cytoplasmic interface controls TRPV channel gating
    Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY
    Elife. 2019
    PubMed ID: 31070581
  • Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
    Worden EJ, Hoffman NA, Hicks CW, Wolberger C
    Cell 2019
    PubMed ID: 30765112
  • Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly
    Matyszewski M, Zheng W, Lueck J, Antiochos B, Egelman EH, Sohn J
    J. Biol. Chem. 2018
    PubMed ID: 30385506

  • Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
    Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S
    Nature 2018
    PubMed ID: 30401837

  • Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1
    Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H
    Proc. Natl. Acad. Sci. USA 2018
    PubMed ID: 30279182

  • Structural insights on TRPV5 gating by endogenous modulators
    Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY
    Nat. Commun. 2018
    PubMed ID: 30305626

  • Structure and gating mechanism of the transient receptor potential channel TRPV3
    Singh AK, McGoldrick LL, Sobolevsky AI
    Nat. Struct. Mol. Biol. 2018
    PubMed ID: 30127359

  • Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6
    Singh AK, McGoldrick LL, Twomey EC, Sobolevsky AI
    Sci. Adv. 2018
    PubMed ID: 30116787

  • DNA melting initiates the RAG catalytic pathway
    Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H
    Nat. Struct. Mol. Biol. 2018
    PubMed ID: 30061602

  • Cryo-EM structure of the gasdermin A3 membrane pore
    Ruan J, Xia S, Liu X, Lieberman J, Wu H
    Nature 2018
    PubMed ID: 29695864

  • Cryo-EM structure of 5-HT3A receptor in its resting conformation
    Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S
    Nat. Commun. 2018
    PubMed ID: 29410406







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