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National CryoEM Facility Acknowledged User Publications

The National Cryo-Electron Microscopy Facility (NCEF), which began operation in May 2017, provides cancer researchers access to the latest cryo-EM technology for high resolution imaging. Publications that report macromolecular structures obtained using data collected at NCEF are listed below.

Structure-based characterization of novel TRPV5 inhibitors
Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, Filizola M, Rohacs T, Moiseenkova-Bell VY
Elife. 2019
PubMed ID: 31647410

A packing for A-form DNA in an icosahedral virus
Wang F, Liu Y, Su Z, Osinski T, de Oliveira GAP, Conway JF, Schouten S, Krupovic M, Prangishvili D, Egelman EH
Proc Natl Acad Sci U S A. 2019
PubMedID: 31636205

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kullhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J
Science 2019
PubMed ID: 31604311

Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii
McGoldrick LL, Singh AK, Demirkhanyan L, Lin TY, Casner RG, Zakharian E, Sobolevsky AI
Nat Commun. 2019
PubMed ID: 31519888

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump
Su CC, Morgan CE, Kambakam S, Rajavel M, Scott H, Huang W, Emerson CC, Taylor DJ, Stewart PL, Bonomo RA, Yu EW
MBio. 2019 
PubMed ID: 31266873

Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs
Hughes SA, Wang F, Wang S, Kreutzberger MAB, Osinski T, Orlova A, Wall JS, Zuo X, Egelman EH, Conticello VP
Proc Natl Acad Sci U S A. 2019
PubMed ID: 31262809

Regulatory switch at the cytoplasmic interface controls TRPV channel gating
Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY
Elife. 2019
PubMed ID: 31070581

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
Worden EJ, Hoffman NA, Hicks CW, Wolberger C
Cell 2019
PubMed ID: 30765112

Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly
Matyszewski M, Zheng W, Lueck J, Antiochos B, Egelman EH, Sohn J
J. Biol. Chem. 2018
PubMed ID: 30385506

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S
Nature 2018
PubMed ID: 30401837

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1
Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H
Proc. Natl. Acad. Sci. USA 2018
PubMed ID: 30279182

Structural insights on TRPV5 gating by endogenous modulators
Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY
Nat. Commun. 2018
PubMed ID: 30305626

Structure and gating mechanism of the transient receptor potential channel TRPV3
Singh AK, McGoldrick LL, Sobolevsky AI
Nat. Struct. Mol. Biol. 2018
PubMed ID: 30127359

Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6
Singh AK, McGoldrick LL, Twomey EC, Sobolevsky AI
Sci. Adv. 2018
PubMed ID: 30116787

DNA melting initiates the RAG catalytic pathway
Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H
Nat. Struct. Mol. Biol. 2018
PubMed ID: 30061602

Cryo-EM structure of the gasdermin A3 membrane pore
Ruan J, Xia S, Liu X, Lieberman J, Wu H
Nature 2018
PubMed ID: 29695864

Cryo-EM structure of 5-HT3A receptor in its resting conformation
Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S
Nat. Commun. 2018
PubMed ID: 29410406

 

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