National Cryo-Electron Microscopy Facility Team Members
The National Cryo-EM Facility (NCEF) consists of a core team that provides cryo-EM services to cancer researchers. The Frederick National Lab Advisory Committee and an ad hoc NCEF working group provides strategic oversight and recommendations to the core team.
National Cryo-EM Team
Ulrich Baxa earned his Ph.D. in Physical Biochemistry, and has research expertise in Biochemistry, Biophysics, and Structural Biology. He has worked in cryo-EM laboratories for many years and has a strong background in structural analysis by electron microscopy and high resolution cryo-electron microscopy imaging.
Thomas Edwards earned his Ph.D. in Molecular Virology focusing on structural studies of intra-cellular virus induced membranes formed during infection by alphaviruses and flaviviruses. In addition to virology, Thomas has expertise in electron tomography and single particle cryo-EM.
Adam Wier earned his Ph.D in structural and molecular biology with a focus on structural studies of protein complexes regulating transcription. He has experience in single particle cryo-EM, including sample preparation, data collection, and data processing.
Matt Hutchison earned his BS in Chemistry and has significant experience developing backend and web applications in a variety of languages. In addition, he has knowledge of data management and system administration, and has a background in laboratory auditing and materials testing.
Scientific Project Manager
Helen Wang earned her MBA with a focus in Project Management and holds a PMP certification. She has worked in academic research in Pharmacology, Physiology and Biophysics. In addition, she has worked in Infectious Disease research in government labs, and has private industry experience in Project Management on government contract projects.
Sriram Subramaniam, the founding Director of NCEF, now serves as its Scientific Advisor. Until July 2018, he worked at NIH as Senior Investigator and Chief of the Biophysics Section in the Laboratory of Cell Biology, Center for Cancer Research, NCI. In Fall 2018, Dr. Subramaniam accepted a faculty position at the University of British Columbia in Vancouver Canada to lead a program in cancer drug design, but remains closely associated with NCEF and the cryo-EM program at Leidos Biomedical Research.
NCEF Advisory Group
Frederick National Lab Advisory Committee (FNLAC) reviews the state of research at the FNLCR and makes recommendations for the best use of its capabilities and infrastructure.
Ad Hoc NCEF Working Group
An ad hoc advisory committee composed of members of the cryo-EM and structural biology communities provides advice to the NCI on operational aspects of the facility. The advisory committee members are listed below.
Ad Hoc NCEF Working Group Chair
Steven J. Ludtke, Ph.D.
Professor, Department of Biochemistry and Molecular Biology
Co-Director, National Center for Macromolecular Imaging, Center for Computational and Integrative Biomedical Research
Baylor College of Medicine
Ad Hoc NCEF Working Group Members
L. Mario Amzel, Ph.D.
Professor, Director, Department of Biophysics and Biophysical Chemistry
The Johns Hopkins University School of Medicine
Edward H. Egelman, Ph.D.
Professor, Department of Biochemistry and Molecular Genetics
University of Virginia School of Medicine
Angela M. Gronenborn, Ph.D.
UPMC Rosalind Franklin Professor and Chair, Department of Structural Biology
Professor, Department of Bioengineering, Swanson School of Engineering
Director, Pittsburgh Center for HIV Protein Interactions
University of Pittsburgh
Stephen C. Harrison, Ph.D.
Giovanni Armenise-Harvard Professor of Basic Medical Sciences, Department of Biological Chemistry and Molecular Pharmacology
Director, Center for Molecular and Cellular Dynamics, Investigator, Howard Hughes Medical Institute
Harvard Medical School
Grant J. Jensen, Ph.D.
Professor of Biophysics and Biology, Division of Biology and Biological Engineering
Investigator, Howard Hughes Medical Institute
California Institute of Technology
Piermaria J. Oddone, Ph.D.
Fermi National Accelerator Laboratory
Z. Hong Zhou, Ph.D.
Director, Electron Imaging Center for NanoMachines
Professor, Department of Microbiology, Immunology and Molecular Genetics
Member, California NanoSystems Institute
University of California, Los Angeles
Los Angeles, California
Sara Hook, Ph.D.
NCEF Program Officer
National Cancer Institute
National Institutes of Health