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Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)

  • Last Modified: 10/21/2014

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Treatment Options for Childhood Non-Hodgkin Lymphoma

Low-stage Childhood Non-Hodgkin Lymphoma
High-stage Childhood B-cell Non-Hodgkin Lymphoma
High-stage Childhood Lymphoblastic Lymphoma
High-stage Childhood Anaplastic Large-cell Lymphoma
Recurrent Childhood Non-Hodgkin Lymphoma
Lymphoproliferative Disease Associated with a Weakened Immune System



Low-stage Childhood Non-Hodgkin Lymphoma

Treatment of low-stage (stage I or II) non-Hodgkin lymphoma in children and adolescents may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I childhood large cell lymphoma, stage I childhood small noncleaved cell lymphoma, stage I childhood lymphoblastic lymphoma, stage I childhood anaplastic large cell lymphoma, stage II childhood large cell lymphoma, stage II childhood small noncleaved cell lymphoma, stage II childhood lymphoblastic lymphoma and stage II childhood anaplastic large cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

High-stage Childhood B-cell Non-Hodgkin Lymphoma

Treatment for high-stage (stage III or IV) B-cell (Burkitt and Burkitt-like) non-Hodgkin lymphoma in children and adolescents may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood large cell lymphoma, stage III childhood small noncleaved cell lymphoma, stage IV childhood large cell lymphoma and stage IV childhood small noncleaved cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

High-stage Childhood Lymphoblastic Lymphoma

Treatment of high-stage (stage III or IV) lymphoblastic lymphoma in children and adolescents may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood lymphoblastic lymphoma and stage IV childhood lymphoblastic lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

High-stage Childhood Anaplastic Large-cell Lymphoma

Treatment of high-stage (stage III or IV) anaplastic large-cell lymphoma in children and adolescents may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III childhood anaplastic large cell lymphoma and stage IV childhood anaplastic large cell lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Recurrent Childhood Non-Hodgkin Lymphoma

There is no standard treatment for patients with recurrent childhood non-Hodgkin lymphoma.

All patients with recurrent childhood non-Hodgkin lymphoma should be considered for clinical trials of new treatments.

Burkitt lymphoma and diffuse large B-cell lymphoma

Treatment options for recurrent Burkitt lymphoma and diffuse large B-cell lymphoma include:

Lymphoblastic lymphoma

Treatment options for recurrent lymphoblastic lymphoma include:

  • Combination chemotherapy.
  • High-dose chemotherapy with stem cell transplant.
  • A clinical trial of targeted therapy (kinase inhibitor) with combination chemotherapy.

Anaplastic large-cell lymphoma

Treatment options for recurrent anaplastic large cell lymphoma include:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Lymphoproliferative Disease Associated with a Weakened Immune System

Treatment of lymphoproliferative disease in children and adolescents with weakened immune systems may include the following: