Clinical Trials Using bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine

Clinical trials are research studies that involve people. The clinical trials on this list are studying bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma

    This is a multicenter, 1:1 randomized Phase III study of intradermal autologous Vigil immunotherapy (1.0 x 10e6 cells / injection; minimum of 4 to a maximum of 12 administrations) in combination with irinotecan and temozolomide in subjects with metastatic Ewing's sarcoma Family of Tumors (ESFT) refractory / intolerant or recurrent to 1 prior line of chemotherapy. Participants undergoing a standard surgical procedure (e.g., tumor biopsy or palliative resection) may have tumor tissue harvested for manufacture of the investigational product, Vigil.
    Location: 7 locations