Clinical Trials Using Curcumin

Clinical trials are research studies that involve people. The clinical trials on this list are studying Curcumin. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-6 of 6
  • Curcumin in Reducing Fatigue in Patients with Chemotherapy-Treated Breast Cancer Undergoing Radiotherapy

    This randomized phase II trial studies how well curcumin works in reducing fatigue in patients with chemotherapy-treated breast cancer undergoing radiotherapy. Patients treated with chemotherapy and radiotherapy are known to have a heightened inflammatory and immune response that may lead to feelings of fatigue. The nuclear factor kappa-B (NF-kB) pathway has emerged as having an important role not only in cancer treatment resistance but in the development of fatigue. Curcumin may reduce symptoms of fatigue by decreasing NF-kB activation. Studying samples of blood from patients with breast cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify possible mechanisms related to the development of fatigue.
    Location: 3 locations

  • Curcumin in Treating HIV Infected and Uninfected Women with High Grade Cervical Squamous Intraepithelial Neoplasia

    This randomized phase II trial studies how well curcumin works in treating human immunodeficiency virus (HIV) infected and uninfected women with high grade cervical squamous intraepithelial neoplasia. Natural or herbal treatments, such as curcumin, may help slow down destroy, or prevent the growth of precancerous cells.
    Location: 2 locations

  • Curcumin in Treating Patients with Prostate Cancer That Was Removed by Surgery

    This randomized phase II trial studies curcumin compared to placebo in treating patients with prostate cancer that was removed by surgery. Curcumin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and may help to decrease or prevent prostate cancer from returning after surgery.
    Location: UT Southwestern / Simmons Cancer Center-Dallas, Dallas, Texas

  • Curcumin in Reducing Joint Pain in Breast Cancer Survivors with Aromatase Inhibitor-Induced Joint Disease

    This phase I trial studies how well curcumin works in reducing joint pain in patients who are breast cancer survivors and have joint disease caused by treatment with aromatase inhibitors. Curcumin is an ingredient of turmeric, a plant in the ginger family, which is commonly used in curries and South Asian and Middle Eastern cooking, and may decrease joint pain in patients with arthritis from other conditions (such as osteoarthritis and rheumatoid arthritis).
    Location: 4 locations

  • Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients with Cancer

    This pilot phase I trial studies the side effects and best dose of curcumin when given together with piperine (piperine extract [standardized]) in reducing inflammation for ureteral stent-induced symptoms in patients with cancer. Curcumin is a spice similar to turmeric and works by decreasing the chemical moderators that produce inflammation in the body. Piperine is pepper and works by increasing the amount of curcumin available in the body when taken with curcumin. Giving curcumin together with piperine may reduce inflammation and discomfort from a ureteric stent in older patients with cancer.
    Location: Mayo Clinic, Rochester, Minnesota

  • Curcumin in Preventing Gastric Cancer in Patients with Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

    This randomized phase IIb trial studies how well curcumin works in preventing gastric cancer in patients with chronic atrophic gastritis and / or gastric intestinal metaplasia. Curcumin is an antioxidant compound found in plants that may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: University of Puerto Rico, San Juan, Puerto Rico