Clinical Trials Using FGFR Inhibitor INCB054828

The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced / metastatic or surgically unresectable solid tumor malignancies harboring activating FGFR mutations or translocations.
Location: 17 locations

The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.
Location: 16 locations

The purpose of this study will be to evaluate the safety, tolerability, and pharmacological activity of pemigatinib in subjects with advanced malignancies. This study will have three parts, dose escalation (Part 1), dose expansion (Part 2) and combination therapy (Part 3).
Location: 6 locations

The purpose of this study is to evaluate the efficacy and safety of pemigatinib (INCB054828) in subjects with myeloid / lymphoid neoplasms with fibroblast growth factor receptor (FGFR) 1 rearrangement.
Location: 5 locations

This phase II trial studies how well pemigatinib works in treating patients with colorectal cancer with mutations (alterations) in a FGFR gene and that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Pemigatinib may stop the growth of tumor cells by blocking FGFR, which is needed for cell growth.
Location: 7 locations

This phase II trial studies how well pemigatinib before surgery works in treating patients with low- or intermediate risk non-muscle invasive bladder cancer that has come back (recurrent). Fibroblast growth factor receptor (FGFR) genes are genes that, when altered, can lead to and promote the growth of cancer in patients. In non-muscle invasive bladder cancer, FGFR3 gene mutations have been seen in patients with recurrent bladder tumors and a prior history of low or intermediate risk tumors. Pemigatinib is an orally administered drug that inhibits fibroblast growth factor receptors 1, 2, and 3 (FGFR 1 / 2 / 3). Pemigatinib followed by surgery may be an effective treatment in patients with low- and intermediate risk non-muscle invasive bladder cancer.
Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

The purpose of this study is to evaluate the safety and efficacy of pemigatinib plus pembrolizumab or pemigatinib alone versus the standard of care for participants with metastatic or unresectable urothelial carcinoma who are not eligible to receive cisplatin, are harboring FGFR3 mutation or rearrangement, and who have not received prior treatment.
Location: See Clinical Trials.gov

This is a multicenter, open-label, nonrandomized, Phase 2 umbrella study of retifanlimab in participants who have advanced or metastatic endometrial cancer that has progressed on or after platinum-based chemotherapy. retifanlimab will be administered as monotherapy or in combination with other immunotherapy or targeted agents.
Location: 2 locations

This phase I trial identifies the best dose and clinical benefit of giving pemigatinib following standard induction chemotherapy in patients with newly diagnosed acute myeloid leukemia. Pemigatinib selectively inhibits FGFR (fibroblast growth factor receptor) activity, a receptor that may contribute to the growth of leukemia cells. The genetic changes responsible for activating the growth of leukemia cells can be unique to each patient and can change during the course of the disease. Chemotherapy drugs, such as cytarabine and daunorubicin work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Location: OHSU Knight Cancer Institute, Portland, Oregon

This phase I trial studies the side effects and best dose of gemcitabine and cisplatin when given together with ivosidenib or pemigatinib in treating patients with cholangiocarcinoma that cannot be removed with surgery (unresectable) or has spread to other places in the body (metastatic). Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Ivosidenib and pemigatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving gemcitabine and cisplatin with ivosidenib or pemigatinib may work better in treating patients with cholangiocarcinoma compared to gemcitabine and cisplatin alone.
Location: 8 locations