Clinical Trials Using Genistein

Clinical trials are research studies that involve people. The clinical trials on this list are studying Genistein. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Genistein in Reducing the Toxicity and Improving the Efficacy of Bacillus Calmette Guerin Intravesical Therapy in Patients with Bladder Cancer

    This phase II trial studies how well genistein works in reducing the toxicity and improving the efficacy of Bacillus Calmette Guerin intravesical (within the bladder) therapy in patients with bladder cancer. Genistein may reduce adverse urinary tract symptoms due to inflammation from intravesical therapy and improve the quality of life of patients with bladder cancer. Genistein may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: 3 locations

  • Genistein in Preventing Cardiometabolic Dysfunction in Patients with Prostate Cancer Undergoing Androgen Deprivation Therapy

    This phase II trial studies genistein in preventing or reducing diabetes (blood sugar), heart, or blood vessels disease (cardiometabolic dysfunction) in patients with prostate cancer undergoing androgen deprivation therapy. Androgen is a male hormone that binds to androgen receptors inside the cancer cells, which causes the cancer cells to grow. Antiandrogen therapy or androgen deprivation therapy prevents this from happening. Despite the benefits of antiandrogen therapy, it is associated with an increased risk of cardiovascular dysfunction, such as high blood sugar and / or high cholesterol. Genistein is a natural supplement that comes from soy that in studies has been shown to decrease blood glucose and cholesterol, and it may prevent or reduce cardiometabolic dysfunction in patients receiving androgen deprivation therapy.
    Location: Emory University Hospital / Winship Cancer Institute, Atlanta, Georgia

  • Genistein in Reducing Side Effects of Chemotherapy in Pediatric Patients with Solid Tumors or Lymphoma

    This randomized pilot clinical trial studies how well genistein works in reducing the side effects of chemotherapy in pediatric patients with solid tumors or lymphoma. Genistein may help reduce the side effects of chemotherapy by reducing cell damage, making sick cells more likely to die, preventing cancer growth, and making cancer cells more responsive to chemotherapy.
    Location: University of Virginia Cancer Center, Charlottesville, Virginia