Clinical Trials Using Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Clinical trials are research studies that involve people. The clinical trials on this list are studying Paclitaxel Albumin-Stabilized Nanoparticle Formulation. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 76-85 of 85

  • Radiation Therapy and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients with Pancreatic Cancer

    This phase I trial studies the side effects and best dose of radiation therapy and paclitaxel albumin-stabilized nanoparticle formulation when given together in treating patients with pancreatic cancer. Radiation therapy uses high energy x-rays and / or protons to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving radiation therapy and paclitaxel albumin-stabilized nanoparticle formulation before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • Nab-Paclitaxel and Carboplatin Followed by Chemoradiation in Treating Patients with Recurrent Head and Neck Cancer

    This phase I trial studies the side effects and best dose of nab-paclitaxel when given together with carboplatin followed by chemoradiation in treating patients with head and neck cancer that has come back (recurrent). Drugs used in chemotherapy, such as nab-paclitaxel, carboplatin, fluorouracil, and hydroxyurea, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving nab-paclitaxel followed by chemoradiation therapy may be a better treatment for head and neck cancer.
    Location: University of Chicago Comprehensive Cancer Center, Chicago, Illinois

  • Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss Without PIK3CA Mutation

    The purpose of this study is to determine whether treatment with alpelisib in combination with nab-paclitaxel is safe and effective in subjects with advanced triple negative breast cancer (aTNBC) who carry either a PIK3CA mutation (Study Part A) or have PTEN loss without PIK3CA mutation (Study Parts B1 and B2)
    Location: 2 locations

  • Study of BGB-A1217 in Combination With Tislelizumab in Advanced Solid Tumors

    The primary objectives of this study are: to assess the safety and tolerability, to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and to determine the recommended Phase 2 dose (RP2D) of BGB-A1217 in combination with tislelizumab in participants with advanced solid tumors.
    Location: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

  • A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC

    This study is designed to determine the efficacy and safety of durvalumab and / or novel oncology therapies, with or without chemotherapy, for first-line Stage IV Non-Small Cell Lung Cancer (NSCLC)
    Location: University of Iowa / Holden Comprehensive Cancer Center, Iowa City, Iowa

  • Cryoablation, Atezolizumab, and Nab-paclitaxel for the Treatment of Locally Advanced or Metastatic Triple Negative Breast Cancer

    This early phase I trial studies the side effects and feasibility of cryoablation, atezolizumab, and nab-paclitaxel in treating patients with triple negative breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or has spread to other places in the body (metastatic). Cryosurgery, also known as cryoablation or cryotherapy, kills tumor cells by freezing them. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving cryoablation, atezolizumab and nab-paclitaxel may improve response to the disease.
    Location: Mayo Clinic in Florida, Jacksonville, Florida

  • Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer

    This phase I trial studies the side effects and best dose of bosentan and how well it works when given together with gemcitabine and nab-paclitaxel for the treatment of pancreatic cancer that cannot be removed by surgery (unresectable). Bosentan may block the hormone endothelin and prevent the growth and spread of pancreatic cancer. Drugs used in chemotherapy, such as gemcitabine and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving bosentan with chemotherapy (gemcitabine and nab-paclitaxel) may work better in treating patients with pancreatic cancer compared to chemotherapy alone.
    Location: City of Hope Comprehensive Cancer Center, Duarte, California

  • Nab-Paclitaxel and Bevacizumab in Treating Patients with Unresectable Stage IV Melanoma, Gynecological or Other Cancers

    This phase I trial studies the side effects and best dose of nab-paclitaxel and bevacizumab in treating patients with stage IV melanoma that cannot be removed by surgery (unresectable), cancer of the cervix, endometrium, ovary, fallopian tube or peritoneal cavity or with other cancers. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as bevacizumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving nab paclitaxel and bevacizumab may kill more tumor cells than nab-paclitaxel alone.
    Location: Mayo Clinic in Rochester, Rochester, Minnesota

  • Telotristat Ethyl in Promoting Weight Stability in Patients with Recurrent Advanced Pancreatic Adenocarcinoma

    This phase II trial studies how well telotristat ethyl works in promoting weight stability in patients with pancreatic adenocarcinoma that has come back (recurrent) and spread to other places in the body (advanced). Telotristat ethyl may decrease bowel movements which may make patients gain weight. Stabilizing weight may help patients tolerate chemotherapy better and improve longevity.
    Location: 3 locations

  • Nab-Paclitaxel and Radiation Therapy in Improving and Maintaining Ambulation in Cancer Patients with Spinal Cord Compression

    This phase II trial studies how well nab-paclitaxel and radiation therapy work in improving and maintaining ambulation in cancer patients with spinal cord compression. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving nab-paclitaxel and radiation therapy may work better in treating epidural spinal cord compression in cancer patients.
    Location: Siteman Cancer Center at Washington University, Saint Louis, Missouri