Clinical Trials Using Pexastimogene Devacirepvec

Clinical trials are research studies that involve people. The clinical trials on this list are studying Pexastimogene Devacirepvec. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma

    This is a Phase 1b / 2a, open-label, multi-center, dose-escalation and safety / efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage, where the maximum feasible dose of Pexa-Vec in combination with Cemiplimab will be determined, followed by an expansion stage. During the expansion patients will receive Cemiplimab alone or in combination with Pexa-Vec, which will be administered either through intravenous (IV) or intratumoral (IT) injection.
    Location: 4 locations