Clinical Trials Using Phenformin Hydrochloride

Clinical trials are research studies that involve people. The clinical trials on this list are studying Phenformin Hydrochloride. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Phenformin Hydrochloride in Combination with BRAF Inhibitor and MEK Inhibitor in Treating Patients with Stage III-IV BRAF V600E / K-Mutated Melanoma

    This phase I trial studies the side effects and best dose of phenformin hydrochloride when given together with dabrafenib, trametinib, vemurafenib, cobimetinib, encorafenib, and binimetinib in treating patients with stage III-IV BRAF V600E / K-mutated melanoma. Phenformin hydrochloride may work by shrinking the tumors. Dabrafenib, trametinib, vemurafenib, cobimetinib, encorafenib, and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving phenformin hydrochloride in combination with a BRAF inhibitor and MEK inhibitor may work better at treating melanoma and might prevent the tumor from becoming resistant to treatment.
    Location: 3 locations