Clinical Trials Using Pirfenidone

Clinical trials are research studies that involve people. The clinical trials on this list are studying Pirfenidone. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-2 of 2
  • Pirfenidone, Carboplatin, and Paclitaxel or Pemetrexed Disodium in Treating Patients with Stage IIIB-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

    This randomized phase I / Ib trial studies the side effects and best dose of pirfenidone and how well it works when given together with carboplatin and paclitaxel or pemetrexed disodium in treating patients with stage IIIB-IV non-small lung cancer that cannot be removed by surgery. Pirfenidone may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin, paclitaxel or pemetrexed disodium, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pirfenidone with carboplatin and paclitaxel or pemetrexed disodium may work better in treating patients with non-small cell lung cancer.
    Location: Moffitt Cancer Center, Tampa, Florida

  • Pirfenidone after Stem Cell Transplant in Treating Participants with Bronchiolitis Obliterans Syndrome

    This phase I trial studies the side effects of pirfenidone after stem cell transplant in treating participants with bronchiolitis obliterans syndrome. Pirfenidone is an anti-inflammatory and antifibrotic agent that may slow the growth of tumor cells.
    Location: Stanford Cancer Institute Palo Alto, Palo Alto, California