Clinical Trials Using Tetracycline Antibiotic

Clinical trials are research studies that involve people. The clinical trials on this list are studying Tetracycline Antibiotic. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Metformin Hydrochloride and Doxycycline in Treating Patients with Localized Breast, Uterine, or Cervical Cancer

    This phase II trial studies how well metformin hydrochloride works together with doxycycline in treating patients with localized breast, uterine, or cervical cancer. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Doxycycline may stop the growth of bacteria by keeping them from making proteins and minimized the toxic side effects of anti-cancer therapy. It is not yet known whether giving metformin hydrochloride together with doxycycline may be a better way in treating patients with localized breast, uterine, or cervical cancer.
    Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

  • Demeclocycline Hydrochloride in Detecting Brain Tumors During Surgery in Patients with Malignant Glioma

    This pilot clinical trial studies the best way to give and best dose of demeclocycline hydrochloride in detecting tumor cells during brain surgery in patients with malignant glioma. Demeclocycline hydrochloride is a commonly used antibiotic that can bind to brain tumor tissue and cause it to glow brightly when viewed with a special microscope. Giving demeclocycline hydrochloride to patients before surgery may improve how well surgeons can see brain tumors with a microscope during surgery.
    Location: Massachusetts General Hospital Cancer Center, Boston, Massachusetts

  • Indwelling Pleural Catheters with or without Doxycycline in Treating Patients with Malignant Pleural Effusions

    This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. The goal of this clinical research study is to learn if adding doxycycline to the use of an IPC can lead to shorter treatment times with IPCs.
    Location: M D Anderson Cancer Center, Houston, Texas