NCI Data Catalog

BRD is a free, publicly accessible literature database that contains peer-reviewed primary and review articles and Standard Operation Procedures (SOPs) in the field of human biospecimen science.
Each literature curation captures the following relevant parameters:

• Biospecimen investigated, analyte(s) of interest, and technology platforms employed
• Pre-analytical factors investigated
• An original summary of relevant results

CDAS is a submission and tracking system for the National Lung Screening Trial (NLST) data and the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial data.
The data includes a:

• summary of the trial.
• description of the data collected.
• searchable list of research projects and publications.

This centralized, controlled-access database is a repository of de-identified, patient level data from phase III clinical trials conducted by NCI’s NCTN network, NCI’s NCORP network, and the Canadian Cancer Trials Group.

After approval of a signed Data Use Agreement, you can download patient level clinical data sets and their associated data dictionaries.

This web tool is for physicians and patients to assess potential therapy options based on specific tumor biomarkers. The focus is on the potential therapy strategies for tumors harboring certain genomic alterations regardless of disease site.

The available data includes:

• study association of a detected genomic alteration with tumor development and growth.
• association of genomic alteration to increased or decreased response to therapy.
• availability of relevant Food and Drug Administration (FDA)-approved therapies or investigational agents in clinical trials.

Use this database for information about cohort studies that follow groups of people over time for cancer incidence, mortality, and other health outcomes. Information includes:

• general study information (e.g., eligibility criteria and size).
• the type of data collected at baseline.
• cancer sites.
• the number of participants diagnosed with cancer.
• biospecimen data.

You can access CEDCD on the Division of Cancer Control and Population Sciences (DCCPS) website.

SEER collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 50% of the U.S. population.

The SEER database includes incidence and population data associated by:

• age.
• sex.
• race.
• year of diagnosis.
• geographic areas.

You can access SEER statistics and the Division of Cancer Control and Population Sciences (DCCPS) data resources on the DCCPS website.

The SEER-CAHPS data resource links data from NCI’s SEER cancer registry program; the Centers for Medicare & Medicaid Services’ (CMS’) Medicare CAHPS patient experience surveys; and longitudinal Medicare claims data on utilization and costs of care for Fee-For-Service beneficiaries.

You can request data access by emailing the required documents to NCISEERCAHPS@nih.gov.

This database links data from both NCI’s SEER cancer registry program and the CMS’ MHOS to provide information about the health-related quality of life (HRQOL) of Medicare Advantage Organization (MAO) enrollees. NCI and CMS sponsor the database.

You can email the required documents to SEER-MHOS@hcqis.org to request access to the data.

GDC provides the cancer research community with a unified data repository that enables data sharing across cancer genomic studies in support of precision medicine. The GDC supports several cancer genome programs at the NCI Center for Cancer Genomics (CCG), including:

• The Cancer Genome Atlas (TCGA)
• Therapeutically Applicable Research to Generate Effective Treatments (TARGET)
• The Cancer Genome Characterization Initiative (CGCI)

Researchers have measured thousands of molecular targets in the NCI panel of 60 human tumor cell lines. You can search for or browse through a list of targets.
Measurements include:

• protein levels.
• RNA measurements.
• mutation status.
• enzyme activity levels.

TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. The goal is to facilitate the discovery of therapeutic targets for childhood cancers and catalyze the translation of these discoveries into clinical applications.

The TARGET data matrix includes:

• genomic data.
• clinical information that doesn’t identify patients.

TCGA is a comprehensive effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies. Through the TCGA Data Portal, you can search, download, and analyze data from over 30 different types of cancer. It contains:

• clinical information that doesn’t identify patients.
• genomic characterization data.
• high level sequence analysis of the tumor genomes.

IDC provides the cancer research community with a cloud-based repository of cancer imaging data, image annotations, and analysis results. IDC uses the Digital Imaging and Communication in Medicine (DICOM) standard to harmonize the data. You can find imaging data from the following NIH/NCI projects:

• The Cancer Genome Atlas (TCGA)
• Lung Imaging Database Consortium (LIDC)
• Clinical Proteomics Tumor Analysis Consortium (CPTAC)
• Human Tumor Atlas Network (HTAN)
• NCI Quantitative Imaging Network (QIN)
• National Library of Medicine Visible Human Project (VHP)

Use this data set (which contains more than 400,000 skin lesion image crops extracted from 3D total body photography [TBP]), for skin cancer detection.

Metadata entries include:

• age.
• sex.
• general anatomic site.
• common patient identifier.
• clinical size.
• various data fields from the TBP Lesion Visualizer.

NDEx allows you to share, store, manipulate, and publish biological network information. The project maintains a public NDEx server and is a joint effort of the UC San Diego School of Medicine and the Cytoscape Consortium.

• Access published networks aggregated from several pathway and interaction databases.
• Create your own networks to use, share, or publish.

The CCDI CCDC is an inventory of pediatric oncology data resources. This includes childhood cancer repositories, registries, knowledge bases, and catalogs that either manage or refer to data.

Visit the catalog website for full details.

CCDI Hub Explore Dashboard: This integrated tool provides you with the search functionality to connect participants with files and samples. It enables you to find data within a single study or across multiple studies, and create synthetic cohorts based on filtered metrics of interest (i.e. demographics, diagnosis, samples).

CCDI Molecular Target Platform (MTP): Use this tool to browse and identify associations between molecular targets, diseases, and drugs specific for childhood cancers.

Childhood Cancer Clinical Data Commons (C3DC): This open access, web application allows you to find harmonized demographic and clinical data, create custom cohorts, and download data for local analysis.

CCDI Data Federation Resource: Search for de-identified individual-level data through the API, which provides an open access subset of the metadata and gives you the location of the complete data set. To determine data access, check the policies for the resource that submitted the data (currently includes the Kids First Data Resource Center, the Pediatric Cancer Data Commons, St. Jude Cloud, and the Treehouse Childhood Cancer Data Initiative).

You can get open access, highly curated, and standardized biospecimen, clinical, and proteomic data from PDC. You can analyze PDC data files using tools found in the CRDC Cloud Resources. Data sets include the following:

• NCI’s Clinical Proteomic Tumor Analysis Consortium (CPTAC)
• Children’s Brain Tumor Tissue Consortium (CBTTC)
• International Cancer Proteogenomic Consortium (ICPC)

CPTAC analyzes cancer biospecimens by mass spectrometry, characterizing and quantifying their constituent proteins, or proteome.

The CPTAC Data Portal is the centralized repository for the dissemination of proteomic data collected by the Proteome Characterization Centers.