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HLA-Arena: Enabling Structure-Guided Pipelines for Personalized Cancer Immunotherapy Design

April 30, 2025 | 10:00 AM – 11:00 AM

Virtual

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Are you interested in learning about the role of Human Leukocyte Antigens (HLA) in cancer? Join Dr. Dinler Antunes of the University of Houston as he presents the HLA-Arena tool—a computational platform that incorporates neoantigen markers and other bioinformatics pipelines to study HLA in cancer.

The HLA-Arena 2.0 environment integrates existing neoantigen discovery resources, such as pVACtools, with new AI-driven bioinformatics methods to help you predict immunogenicity, off-target toxicity, and T-cell receptor (TCR) specificity.

By leveraging structural data and accounting for biochemical properties driving TCR-peptide-HLA binding specificity, HLA-Arena can help facilitate the design of better and safer cancer vaccines and T-cell-based immunotherapies for patients with different types of cancers.

NCI’s Informatics Technology for Cancer Research Program funds HLA-Arena.

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