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HIV and AIDS Research News & Events

Learn about upcoming meetings relevant to HIV malignancies and recent news about NCI HIV/AIDS and HIV malignancy research.

News

Read about Dr. Robert Yarchoan and the Office of HIV and AIDS Malignancy. This article highlights OHAM's efforts in HIV/AIDS malignancy research.
POZ
July 2019
 
Researchers from NCI and the Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab.
JAMA Oncology
June 2019
 
Researchers from the AIDS Malignancy Consortium have completed a cervical cancer trial in sub-Saharan Africa showing that women living with HIV can be treated with concomitant chemoradiotherapy using the same dose as HIV-negative women. 
Gynecologic Oncology
April 2019
 
Researchers at NCI have demonstrated that cytokine dysregulation is a hallmark of primary effusion lymphoma pathogenesis, symptom profile and natural history.
Blood
February 2019
 
The latest information on the epidemiological, clinical features and treatment options for Kaposi sarcoma is highlighted in this review.
Nature Reviews Disease Primers
January 2019
 
Two independent groups describe circular RNAs in Kaposi sarcoma herpesvirus (KSHV) infected cells that may play a role in viral replication and pathogenesis.
Proceedings of the National Academy of Sciences
December 2018
Proceedings of the National Academy of Sciences
September 2018
 
A NCI and NIAID supported clinical trial for Kaposi sarcoma (KS) suggests that paclitaxel  is a superior treatment when compared to bleomycin and vincristine with ART or oral etoposide with ART for patients with advanced KS in low resource settings. 
June 2018 
 
Investigators at the Center for Cancer Research, NCI describe how different simian immunodeficiency virus (SIV) vaccines respond differently to outside stimuli.  The activation of hypoxia and the inflammasome in CD14+ monocytes result in a decrease risk of SIV acquisition. 
Nature Medicine
May 2018

Investigators at NCI identify the receptor for one of the HLA proteins (HLA-E) as a potential new target for HIV 
treatment. Blockade of this pathway has been implicated in many cancers and autoimmune diseases. 
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells                                                                                     
Science                                                                                                                                                                                                                                              
January 2018

People living with HIV have an increased cancer burden, even in the absence of over immunosuprresion. 
In this review,  NCI researchers Drs. Yarchoan and  Uldrick describe the current epidemiology, pathogenesis and 
prevention strategies of HIV-associated cancers and related diseases.  
HIV-Associated Cancers and Related Diseases                                                                                                                                                                                
New England Journal of Medicine 
March 2018

NCI supported researchers have determined the structure of the Kaposi sarcoma-associated herpesvirus (KSHV), also 
called human herpesvirus 8. This may provide a target for the development of antiviral agents.
Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication
Nature
January 2018

Recommendations for eligibility for HIV-positive patients to enroll in oncology clinical trials 
Journal of Clinical Oncology                                                                                                                                                                                                           
October 2017

Structural map of Kaposi sarcoma-associated herpesvirus RNA provides clues to molecular interactions
News - Center for Cancer Research
April 2017

Possible new treatment for Kaposi sarcoma
News - Center for Cancer Research
December 2016

Ultraviolet Radiation and Kaposi Sarcoma Incidence in a Nationwide US Cohort of HIV-Infected Men
Journal of the National Cancer Institute
October 2016

 

Events

Save the Date

NIH Campus, Bethesda, MD, USA
October 21-22, 2019

 

 

 

 

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