NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:6-azauracil riboside
Chemical structure:
  • 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl
  • 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione
  • 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside
  • 6-azauracil-.beta.-D-riboside