7-hydroxystaurosporine
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.
| Code name: | UCN-01 |
|---|---|
| Chemical structure: | 8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino) |
| IND number: | 49169 |
| NSC code: | 638850 |