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7-hydroxystaurosporine

A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.
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Code name:UCN-01
Chemical structure:8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)
IND number:49169
NSC code:638850
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