NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

autologous peripheral blood lymphocytes cotransduced with retroviral vectors encoding inducible IL-12 and anti-NY-ESO-1 TCR
Human autologous peripheral blood lymphocytes (PBLs) transduced with two retroviral vectors, one encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 and a second that encodes an inducible single-chain form of interleukin-12 (IL-12) driven by a nuclear factor of activated T-cells (NFAT)-responsive promoter, with potential immunomodulating and antineoplastic activities. Following isolation of lymphocytes, retroviral vector transduction, and expansion of the cells ex vivo, the inducible IL-12/anti-NY-ESO-1 TCR-expressing autologous PBLs are re-administered into the patient by intravenous injection. As the transduced PBLs traverse the patient's circulatory system, they can bind to NY-ESO-1-overexpressing tumor cells. This binding activates the TCR signaling pathway in the transduced PBLs, which promotes NFAT-dependent gene transcription and induces expression of the cotransduced IL-12. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the NY-ESO-1-overexpressing tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. NFAT, a family of transcription factors involved in immune responses, is activated by calcium signaling, which can occur downstream of TCR activation. Use of a retroviral vector to express an inducible IL-12 may remove the requirement for concomitant administration of interleukin-2 (IL-2) that is a component of conventional cell transfer immunotherapies. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:autologous lymphocytes cotransduced with genes encoding IL-12 and anti-NY-ESO-1 TCR
autologous PBL cotransduced with retroviral vectors encoding inducible IL-12 and anti-NY-ESO-1 TCR
IL-12 plus anti-ESO-1 TCR PBL
IL-12/Anti-NY-ESO-1 TCR-expressing autologous PBL
IL-12/anti-NY-ESO-1 TCR-expressing autologous peripheral blood lymphocytes
IL-12/Anti-NY-ESO-1 TCR-expressing autologous peripheral blood lymphocytes
inducible IL-12/Anti-NY-ESO-1 TCR-expressing autologous PBL
inducible IL-12/Anti-NY-ESO-1 TCR-expressing autologous peripheral blood lymphocytes