NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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anti-CD22 scFv TCRz:41BB-CAR lentiviral vector-transduced autologous T lymphocytes
Autologous human T lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T cell receptor consisting of an anti-CD22 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive cancer are transduced with this lentiviral vector that encodes the CAR gene specific for CD22. After isolation, transduction, expansion in culture and reintroduction into the patient, the anti-CD22 scFv TCRz:41BB-CAR lentiviral vector-transduced autologous T lymphocytes express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:autologous T lymphocytes expressing CD22 CARs-expressing tandem TCR-zeta/4-1BB
autologous T lymphocytes expressing CD22 chimeric antigen receptors expressing tandem TCR-zeta and 4-1BB
TCRzeta/4-1BB CART22 cells
TCRζ/4-1BB CART22 cells